ENSMUSG00000032293


Mus musculus

Features
Gene ID: ENSMUSG00000032293
  
Biological name :Ireb2
  
Synonyms : Ireb2 / Iron-responsive element-binding protein 2 / Q811J3
  
Possible biological names infered from orthology : P48200
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: B
Gene start: 54863789
Gene end: 54912530
  
Corresponding Affymetrix probe sets: 10585444 (MoGene1.0st)   1433527_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034843
Ensembl peptide - ENSMUSP00000149766
NCBI entrez gene - 64602     See in Manteia.
MGI - MGI:1928268
RefSeq - XM_017313500
RefSeq - NM_022655
RefSeq - XM_006511335
RefSeq - XM_017313499
RefSeq Peptide - NP_073146
swissprot - A0A1L1SS62
swissprot - Q811J3
Ensembl - ENSMUSG00000032293
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ireb2ENSDARG00000021466Danio rerio
 IREB2ENSGALG00000035462Gallus gallus
 IREB2ENSG00000136381Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aco1 / P28271 / aconitase 1 / P21399*ENSMUSG0000002840556


Protein motifs (from Interpro)
Interpro ID Name
 IPR000573  Aconitase A/isopropylmalate dehydratase small subunit, swivel domain
 IPR001030  Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain
 IPR006249  Aconitase/Iron-responsive element-binding protein 2
 IPR015928  Aconitase/3-isopropylmalate dehydratase, swivel
 IPR015931  Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3
 IPR015932  Aconitase, domain 2
 IPR018136  Aconitase family, 4Fe-4S cluster binding site
 IPR029755  Iron regulatory protein 2
 IPR036008  Aconitase, iron-sulfur domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006417 regulation of translation IMP
 biological_processGO:0006782 protoporphyrinogen IX biosynthetic process IMP
 biological_processGO:0006879 cellular iron ion homeostasis IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009791 post-embryonic development IGI
 biological_processGO:0010468 regulation of gene expression IGI
 biological_processGO:0017148 negative regulation of translation IEA
 biological_processGO:0030316 osteoclast differentiation IEP
 biological_processGO:0034101 erythrocyte homeostasis IMP
 biological_processGO:0050892 intestinal absorption IGI
 biological_processGO:0055072 iron ion homeostasis IGI
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0003723 RNA binding ISO
 molecular_functionGO:0030350 iron-responsive element binding IEA
 molecular_functionGO:0030371 translation repressor activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051539 4 iron, 4 sulfur cluster binding IEA


Pathways (from Reactome)
Pathway description
Iron uptake and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Ihhtm1Amc/Ihhtm2Amc,Pth1rtm1Hmk/Pth1rtm2Hmk,Tg(Bglap2-cre)1Kry/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ireb2tm1Mwh/Ireb2tm1Mwh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL

Allelic Composition: Fbxl5tm1Kei/Fbxl5tm1Kei,Ireb2tm1Roua/Ireb2tm1Roua
Genetic Background: B6.Cg-Fbxl5tm1Kei Ireb2tm1Roua

Allelic Composition: Ireb2tm1Roua/Ireb2tm1Roua
Genetic Background: B6.Cg-Ireb2tm1Roua

Allelic Composition: Ireb2tm1.1Eal/Ireb2tm1.1Eal
Genetic Background: B6J.129-Ireb2tm1.1Eal

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ihhtm1Amc/Ihhtm2Amc,Pth1rtm1Hmk/Pth1rtm2Hmk,Tg(Bglap2-cre)1Kry/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col8a2tm1.1Asj/Col8a2tm1.1Asj
Genetic Background: involves: 129S6/SvEvTac

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Ireb2tm1.1Eal/Ireb2tm1.1Eal
Genetic Background: B6J.129-Ireb2tm1.1Eal

 MP:0000832 abnormal thalamus morphology "malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ihhtm1Amc/Ihhtm2Amc,Pth1rtm1Hmk/Pth1rtm2Hmk,Tg(Bglap2-cre)1Kry/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB

Allelic Composition: Ireb2tm1.1Eal/Ireb2tm1.1Eal
Genetic Background: B6J.129-Ireb2tm1.1Eal

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ihhtm1Amc/Ihhtm2Amc,Pth1rtm1Hmk/Pth1rtm2Hmk,Tg(Bglap2-cre)1Kry/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB

 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
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Allelic Composition: Ihhtm1Amc/Ihhtm2Amc,Pth1rtm1Hmk/Pth1rtm2Hmk,Tg(Bglap2-cre)1Kry/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Col8a2tm1.1Asj/Col8a2tm1.1Asj
Genetic Background: involves: 129S6/SvEvTac

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Ihhtm1Amc/Ihhtm2Amc,Pth1rtm1Hmk/Pth1rtm2Hmk,Tg(Bglap2-cre)1Kry/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB

 MP:0000899 abnormal colliculi "malformed inferior and superior colliculus" [J:50311]
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Allelic Composition: Ihhtm1Amc/Ihhtm2Amc,Pth1rtm1Hmk/Pth1rtm2Hmk,Tg(Bglap2-cre)1Kry/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB

 MP:0000904 abnormal superior colliculus "dysmorphology or disorganization of the paired superior eminence of the mesencephalic tectum that is involved in auditory processing" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ireb2tm1.1Eal/Ireb2tm1.1Eal
Genetic Background: B6J.129-Ireb2tm1.1Eal

 MP:0000953 abnormal oligodendrocyte morphology "anomalous structure, number or composition of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col8a2tm1.1Asj/Col8a2tm1.1Asj
Genetic Background: involves: 129S6/SvEvTac

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ihhtm1Amc/Ihhtm2Amc,Pth1rtm1Hmk/Pth1rtm2Hmk,Tg(Bglap2-cre)1Kry/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB

Allelic Composition: Ireb2tm1Mwh/Ireb2tm1Mwh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Ihhtm1Amc/Ihhtm2Amc,Pth1rtm1Hmk/Pth1rtm2Hmk,Tg(Bglap2-cre)1Kry/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Col8a2tm1.1Asj/Col8a2tm1.1Asj
Genetic Background: involves: 129S6/SvEvTac

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Col8a2tm1.1Asj/Col8a2tm1.1Asj
Genetic Background: involves: 129S6/SvEvTac

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Ihhtm1Amc/Ihhtm2Amc,Pth1rtm1Hmk/Pth1rtm2Hmk,Tg(Bglap2-cre)1Kry/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Ihhtm1Amc/Ihhtm2Amc,Pth1rtm1Hmk/Pth1rtm2Hmk,Tg(Bglap2-cre)1Kry/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Ihhtm1Amc/Ihhtm2Amc,Pth1rtm1Hmk/Pth1rtm2Hmk,Tg(Bglap2-cre)1Kry/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Fbxl5Gt(OST386421)Lex/Fbxl5+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001770 abnormal iron level "anomalous concentrations of this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col8a2tm1.1Asj/Col8a2tm1.1Asj
Genetic Background: involves: 129S6/SvEvTac

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: Col8a2tm1.1Asj/Col8a2tm1.1Asj
Genetic Background: involves: 129S6/SvEvTac

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ireb2tm1Mwh/Ireb2tm1Mwh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ireb2tm1Mwh/Ireb2tm1Mwh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ireb2tm1Mwh/Ireb2tm1Mwh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Fbxl5tm1Kei/Fbxl5tm1Kei,Ireb2tm1Roua/Ireb2tm1Roua
Genetic Background: B6.Cg-Fbxl5tm1Kei Ireb2tm1Roua

Allelic Composition: Ireb2tm1Roua/Ireb2tm1Roua
Genetic Background: B6.Cg-Ireb2tm1Roua

Allelic Composition: Ireb2tm1.1Eal/Ireb2tm1.1Eal
Genetic Background: B6J.129-Ireb2tm1.1Eal

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ireb2tm1.1Eal/Ireb2tm1.1Eal
Genetic Background: B6J.129-Ireb2tm1.1Eal

 MP:0002810 microcytic anemia "anemia in which the circulating erythrocyte corpuscular volume is smaller than normal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ireb2tm1.1Eal/Ireb2tm1.1Eal
Genetic Background: B6J.129-Ireb2tm1.1Eal

 MP:0002813 microcytosis "the presence of unusually small erythrocytes in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ireb2tm1Mwh/Ireb2tm1Mwh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL

Allelic Composition: Fbxl5tm1Kei/Fbxl5tm1Kei,Ireb2tm1Roua/Ireb2tm1Roua
Genetic Background: B6.Cg-Fbxl5tm1Kei Ireb2tm1Roua

Allelic Composition: Ireb2tm1Roua/Ireb2tm1Roua
Genetic Background: B6.Cg-Ireb2tm1Roua

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ireb2tm1Mwh/Ireb2tm1Mwh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL

Allelic Composition: Fbxl5tm1Kei/Fbxl5tm1Kei,Ireb2tm1Roua/Ireb2tm1Roua
Genetic Background: B6.Cg-Fbxl5tm1Kei Ireb2tm1Roua

Allelic Composition: Ireb2tm1Roua/Ireb2tm1Roua
Genetic Background: B6.Cg-Ireb2tm1Roua

Allelic Composition: Ireb2tm1.1Eal/Ireb2tm1.1Eal
Genetic Background: B6J.129-Ireb2tm1.1Eal

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Ireb2tm1.1Eal/Ireb2tm1.1Eal
Genetic Background: B6J.129-Ireb2tm1.1Eal

 MP:0003271 abnormal duodenum morphology "malformation in the first division of the small intestine that extends from the pyloris to the junction with the jejunum " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL

 MP:0004102 abnormal dorsal striatum morphology "any structural abnormality of the regions of the caudate nucleus and the putamen that lie dorsal to the anterior commissure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ireb2tm1.1Eal/Ireb2tm1.1Eal
Genetic Background: B6J.129-Ireb2tm1.1Eal

 MP:0004147 increased porphyrin level "elevated concentration of porphyrins or protoporphyrins" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ireb2tm1.1Eal/Ireb2tm1.1Eal
Genetic Background: B6J.129-Ireb2tm1.1Eal

 MP:0004742 abnormal vestibular system physiology "any functional anomaly of the sensory system responsible for the sense of head position and movement of the body through space; such anomalies may include impaired balance, dizziness, poor regulation of postural muscle tone and inability to detect quick movements of the head " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ihhtm1Amc/Ihhtm2Amc,Pth1rtm1Hmk/Pth1rtm2Hmk,Tg(Bglap2-cre)1Kry/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB

 MP:0005156 bradykinesia "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]
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Allelic Composition: Ihhtm1Amc/Ihhtm2Amc,Pth1rtm1Hmk/Pth1rtm2Hmk,Tg(Bglap2-cre)1Kry/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ireb2tm1.1Eal/Ireb2tm1.1Eal
Genetic Background: B6J.129-Ireb2tm1.1Eal

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fbxl5tm1Kei/Fbxl5tm1Kei,Ireb2tm1Roua/Ireb2tm1Roua
Genetic Background: B6.Cg-Fbxl5tm1Kei Ireb2tm1Roua

Allelic Composition: Ireb2tm1Roua/Ireb2tm1Roua
Genetic Background: B6.Cg-Ireb2tm1Roua

Allelic Composition: Ireb2tm1.1Eal/Ireb2tm1.1Eal
Genetic Background: B6J.129-Ireb2tm1.1Eal

 MP:0005637 abnormal iron homeostasis "anomaly in the state of equilibrium in the body with respect to this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:64456]
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Allelic Composition: Ihhtm1Amc/Ihhtm2Amc,Pth1rtm1Hmk/Pth1rtm2Hmk,Tg(Bglap2-cre)1Kry/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB

Allelic Composition: Ireb2tm1Mwh/Ireb2tm1Mwh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL

Allelic Composition: Ireb2tm1.1Eal/Ireb2tm1.1Eal
Genetic Background: B6J.129-Ireb2tm1.1Eal

 MP:0005642 decreased mean corpuscular hemoglobin concentration "less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
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Allelic Composition: Fbxl5tm1Kei/Fbxl5tm1Kei,Ireb2tm1Roua/Ireb2tm1Roua
Genetic Background: B6.Cg-Fbxl5tm1Kei Ireb2tm1Roua

Allelic Composition: Ireb2tm1Roua/Ireb2tm1Roua
Genetic Background: B6.Cg-Ireb2tm1Roua

Allelic Composition: Ireb2tm1.1Eal/Ireb2tm1.1Eal
Genetic Background: B6J.129-Ireb2tm1.1Eal

 MP:0005654 porphyria "aquired or inherited group of disorders characterized by excessive production of porphyrins or their precursors; if aquired, it results from inhibition of enzymes in the heme metabolic pathway by drugs, toxins or abnormal metabolites" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ireb2tm1.1Eal/Ireb2tm1.1Eal
Genetic Background: B6J.129-Ireb2tm1.1Eal

 MP:0008743 decreased liver iron level "reduction in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fbxl5tm1Kei/Fbxl5tm1Kei,Ireb2tm1Roua/Ireb2tm1Roua
Genetic Background: B6.Cg-Fbxl5tm1Kei Ireb2tm1Roua

 MP:0008807 increased liver iron level "increase in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ihhtm1Amc/Ihhtm2Amc,Pth1rtm1Hmk/Pth1rtm2Hmk,Tg(Bglap2-cre)1Kry/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB

Allelic Composition: Ireb2tm1Mwh/Ireb2tm1Mwh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL

Allelic Composition: Ireb2tm1Roua/Ireb2tm1Roua
Genetic Background: B6.Cg-Ireb2tm1Roua

Allelic Composition: Ireb2tm1.1Eal/Ireb2tm1.1Eal
Genetic Background: B6J.129-Ireb2tm1.1Eal

 MP:0008808 decreased spleen iron level "reduction in the amount of iron present in the spleen tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ireb2tm1Mwh/Ireb2tm1Mwh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL

Allelic Composition: Ireb2tm1Roua/Ireb2tm1Roua
Genetic Background: B6.Cg-Ireb2tm1Roua

 MP:0008810 increased circulating iron level "elevation in the concentration of iron in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fbxl5tm1Kei/Fbxl5tm1Kei,Ireb2tm1Roua/Ireb2tm1Roua
Genetic Background: B6.Cg-Fbxl5tm1Kei Ireb2tm1Roua

 MP:0008935 decreased mean platelet volume "reduced average content of platelet cells over normal" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Ireb2tm1.1Eal/Ireb2tm1.1Eal
Genetic Background: B6J.129-Ireb2tm1.1Eal

 MP:0009940 abnormal hippocampus pyramidal cell morphology "any structural anomaly of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ireb2tm1.1Eal/Ireb2tm1.1Eal
Genetic Background: B6J.129-Ireb2tm1.1Eal

 MP:0009978 abnormal cerebellum white matter morphology 
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Allelic Composition: Ireb2tm1.1Eal/Ireb2tm1.1Eal
Genetic Background: B6J.129-Ireb2tm1.1Eal

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Ihhtm1Amc/Ihhtm2Amc,Pth1rtm1Hmk/Pth1rtm2Hmk,Tg(Bglap2-cre)1Kry/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB

 MP:0010067 increased red blood cell distribution width "higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"]
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Allelic Composition: Ireb2tm1.1Eal/Ireb2tm1.1Eal
Genetic Background: B6J.129-Ireb2tm1.1Eal

 MP:0010375 increased kidney iron level "increase in the amount of iron present in the renal tissue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ireb2tm1.1Eal/Ireb2tm1.1Eal
Genetic Background: B6J.129-Ireb2tm1.1Eal

 MP:0011890 increased circulating ferritin level "elevated concentration in the blood of ferritin, a ubiquitous intracellular protein that stores iron and releases it in a controlled fashion; some ferritin is also found in the blood and is measured in tests for overall iron levels, anemia and chronic diseases" [MGI:csmith]
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Allelic Composition: Ihhtm1Amc/Ihhtm2Amc,Pth1rtm1Hmk/Pth1rtm2Hmk,Tg(Bglap2-cre)1Kry/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB

Allelic Composition: Ireb2tm1.1Eal/Ireb2tm1.1Eal
Genetic Background: B6J.129-Ireb2tm1.1Eal

 MP:0011897 decreased circulating unsaturated transferrin level "reduction in the concentration of transferrin that is not saturated (bound) with iron; this represents the reserve capacity of transferrin and is often measured by the Unsaturated Iron Binding Capacity (UIBC) test" [MGI:csmith]
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Allelic Composition: Fbxl5tm1Kei/Fbxl5tm1Kei,Ireb2tm1Roua/Ireb2tm1Roua
Genetic Background: B6.Cg-Fbxl5tm1Kei Ireb2tm1Roua

 MP:0020338 abnormal hippocampal pyramidal neuron dendrite morphology "structural anomaly of the highly branched tree-like process of the hippocampal neurons that have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base" [CL_1001571, ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Ireb2tm1.1Eal/Ireb2tm1.1Eal
Genetic Background: B6J.129-Ireb2tm1.1Eal

 MP:0020365 increased brain iron level "increase in the amount of iron present in the brain tissue" [MGI:Anna]
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Allelic Composition: Ihhtm1Amc/Ihhtm2Amc,Pth1rtm1Hmk/Pth1rtm2Hmk,Tg(Bglap2-cre)1Kry/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB

Allelic Composition: Ireb2tm1.1Eal/Ireb2tm1.1Eal
Genetic Background: B6J.129-Ireb2tm1.1Eal

 MP:0020366 decreased brain iron level "reduction in the amount of iron present in the brain tissue" [MGI:Anna]
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Allelic Composition: Ireb2tm1.1Eal/Ireb2tm1.1Eal
Genetic Background: B6J.129-Ireb2tm1.1Eal

 MP:0020368 decreased heart iron level "reduction in the amount of iron present in the heart tissue" [MGI:Anna]
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Allelic Composition: Ireb2tm1.1Eal/Ireb2tm1.1Eal
Genetic Background: B6J.129-Ireb2tm1.1Eal

 MP:0020369 increased intestinal iron level "increase in the amount of iron present in the large or small intestinal tissue" [MGI:Anna]
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Allelic Composition: Ihhtm1Amc/Ihhtm2Amc,Pth1rtm1Hmk/Pth1rtm2Hmk,Tg(Bglap2-cre)1Kry/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB

Allelic Composition: Ireb2tm1Mwh/Ireb2tm1Mwh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL

Allelic Composition: Ireb2tm1.1Eal/Ireb2tm1.1Eal
Genetic Background: B6J.129-Ireb2tm1.1Eal

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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