ENSMUSG00000028405


Mus musculus

Features
Gene ID: ENSMUSG00000028405
  
Biological name :Aco1
  
Synonyms : Aco1 / aconitase 1 / P28271
  
Possible biological names infered from orthology : P21399
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: A5
Gene start: 40143081
Gene end: 40198338
  
Corresponding Affymetrix probe sets: 10503966 (MoGene1.0st)   1423644_at (Mouse Genome 430 2.0 Array)   1447080_at (Mouse Genome 430 2.0 Array)   1456728_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000100038
NCBI entrez gene - 11428     See in Manteia.
MGI - MGI:87879
RefSeq - NM_007386
RefSeq Peptide - NP_031412
swissprot - P28271
Ensembl - ENSMUSG00000028405
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aco1ENSDARG00000026376Danio rerio
 ACO1ENSGALG00000002162Gallus gallus
 ACO1ENSG00000122729Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ireb2 / Q811J3 / Iron-responsive element-binding protein 2 / P48200*ENSMUSG0000003229361


Protein motifs (from Interpro)
Interpro ID Name
 IPR000573  Aconitase A/isopropylmalate dehydratase small subunit, swivel domain
 IPR001030  Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain
 IPR006249  Aconitase/Iron-responsive element-binding protein 2
 IPR015928  Aconitase/3-isopropylmalate dehydratase, swivel
 IPR015931  Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3
 IPR015932  Aconitase, domain 2
 IPR018136  Aconitase family, 4Fe-4S cluster binding site
 IPR029784  Iron regulatory protein 1
 IPR036008  Aconitase, iron-sulfur domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006099 tricarboxylic acid cycle IEA
 biological_processGO:0006101 citrate metabolic process IEA
 biological_processGO:0006417 regulation of translation IMP
 biological_processGO:0006879 cellular iron ion homeostasis IMP
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009791 post-embryonic development IGI
 biological_processGO:0010040 response to iron(II) ion ISS
 biological_processGO:0010468 regulation of gene expression IGI
 biological_processGO:0050892 intestinal absorption IGI
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003723 RNA binding ISO
 molecular_functionGO:0003994 aconitate hydratase activity ISO
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0030350 iron-responsive element binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051538 3 iron, 4 sulfur cluster binding IEA
 molecular_functionGO:0051539 4 iron, 4 sulfur cluster binding ISO


Pathways (from Reactome)
Pathway description
Iron uptake and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr1tm1Spo/Tgfbr1tm1Spo
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129 * C57BL/6)

Allelic Composition: Aco1tm1.2Mwh/Aco1tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005637 abnormal iron homeostasis "anomaly in the state of equilibrium in the body with respect to this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:64456]
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Allelic Composition: Sox5tm1Vlf/Sox5+,Sox6tm1Vlf/Sox6+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Fbxl5Gt(OST386421)Lex/Fbxl5+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Tgfbr1tm1Spo/Tgfbr1tm1Spo
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129 * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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