ENSG00000122729


Homo sapiens

Features
Gene ID: ENSG00000122729
  
Biological name :ACO1
  
Synonyms : ACO1 / aconitase 1 / P21399
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: p21.1
Gene start: 32384603
Gene end: 32454769
  
Corresponding Affymetrix probe sets: 207071_s_at (Human Genome U133 Plus 2.0 Array)   237622_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000309477
Ensembl peptide - ENSP00000369255
Ensembl peptide - ENSP00000438733
NCBI entrez gene - 48     See in Manteia.
OMIM - 100880
RefSeq - XM_011517888
RefSeq - NM_001278352
RefSeq - NM_002197
RefSeq - XM_005251476
RefSeq Peptide - NP_001265281
RefSeq Peptide - NP_002188
swissprot - P21399
swissprot - V9HWB7
Ensembl - ENSG00000122729
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aco1ENSDARG00000026376Danio rerio
 ACO1ENSGALG00000002162Gallus gallus
 Aco1ENSMUSG00000028405Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IREB2 / P48200 / iron responsive element binding protein 2ENSG0000013638160


Protein motifs (from Interpro)
Interpro ID Name
 IPR000573  Aconitase A/isopropylmalate dehydratase small subunit, swivel domain
 IPR001030  Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain
 IPR006249  Aconitase/Iron-responsive element-binding protein 2
 IPR015928  Aconitase/3-isopropylmalate dehydratase, swivel
 IPR015931  Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3
 IPR015932  Aconitase, domain 2
 IPR018136  Aconitase family, 4Fe-4S cluster binding site
 IPR029784  Iron regulatory protein 1
 IPR036008  Aconitase, iron-sulfur domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006099 tricarboxylic acid cycle IEA
 biological_processGO:0006101 citrate metabolic process IDA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006879 cellular iron ion homeostasis TAS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009791 post-embryonic development IEA
 biological_processGO:0010040 response to iron(II) ion IDA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0050892 intestinal absorption IEA
 cellular_componentGO:0005737 cytoplasm IMP
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003723 RNA binding NAS
 molecular_functionGO:0003994 aconitate hydratase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0030350 iron-responsive element binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051538 3 iron, 4 sulfur cluster binding IMP
 molecular_functionGO:0051539 4 iron, 4 sulfur cluster binding IMP


Pathways (from Reactome)
Pathway description
Iron uptake and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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