ENSG00000137198


Homo sapiens

Features
Gene ID: ENSG00000137198
  
Biological name :GMPR
  
Synonyms : GMPR / guanosine monophosphate reductase / P36959
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p22.3
Gene start: 16238580
Gene end: 16295549
  
Corresponding Affymetrix probe sets: 204187_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000259727
NCBI entrez gene - 2766     See in Manteia.
OMIM - 139265
RefSeq - NM_006877
RefSeq - XM_011514508
RefSeq Peptide - NP_006868
swissprot - P36959
Ensembl - ENSG00000137198
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gmprENSDARG00000016160Danio rerio
 GMPRENSGALG00000012705Gallus gallus
 GmprENSMUSG00000000253Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GMPR2 / Q9P2T1 / guanosine monophosphate reductase 2ENSG0000010093880
IMPDH1 / P20839 / inosine monophosphate dehydrogenase 1ENSG0000010634830
IMPDH2 / P12268 / inosine monophosphate dehydrogenase 2ENSG0000017803529


Protein motifs (from Interpro)
Interpro ID Name
 IPR001093  IMP dehydrogenase/GMP reductase
 IPR005993  GMP reductase
 IPR013785  Aldolase-type TIM barrel
 IPR015875  IMP dehydrogenase / GMP reductase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006144 purine nucleobase metabolic process IEA
 biological_processGO:0009117 nucleotide metabolic process IEA
 biological_processGO:0009409 response to cold TAS
 biological_processGO:0043101 purine-containing compound salvage TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:1902560 GMP reductase complex IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003920 GMP reductase activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Purine salvage


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000137198 GMPR / P36959 / guanosine monophosphate reductase  / complex






 

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