ENSG00000137815


Homo sapiens

Features
Gene ID: ENSG00000137815
  
Biological name :RTF1
  
Synonyms : Q92541 / RTF1 / RTF1 homolog, Paf1/RNA polymerase II complex component
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q15.1
Gene start: 41408408
Gene end: 41483563
  
Corresponding Affymetrix probe sets: 212301_at (Human Genome U133 Plus 2.0 Array)   212302_at (Human Genome U133 Plus 2.0 Array)   230832_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000374280
Ensembl peptide - ENSP00000452973
NCBI entrez gene - 23168     See in Manteia.
OMIM - 611633
RefSeq - NM_015138
RefSeq Peptide - NP_055953
swissprot - Q92541
swissprot - H0YKX1
Ensembl - ENSG00000137815
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rtf1ENSDARG00000008947Danio rerio
 RTF1ENSGALG00000008595Gallus gallus
 Rtf1ENSMUSG00000027304Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004343  Plus-3 domain
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR031102  RNA polymerase-associated protein Rtf1
 IPR036128  Plus3-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001711 endodermal cell fate commitment IEA
 biological_processGO:0001832 blastocyst growth IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016567 protein ubiquitination TAS
 biological_processGO:0016570 histone modification IEA
 biological_processGO:0019827 stem cell population maintenance IEA
 biological_processGO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0051571 positive regulation of histone H3-K4 methylation IEA
 biological_processGO:0080182 histone H3-K4 trimethylation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0016593 Cdc73/Paf1 complex IEA
 molecular_functionGO:0001076 transcription factor activity, RNA polymerase II transcription factor binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:1990269 RNA polymerase II C-terminal domain phosphoserine binding IBA


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
RNA Polymerase II Pre-transcription Events
RNA Polymerase II Transcription Elongation
E3 ubiquitin ligases ubiquitinate target proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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