ENSG00000138600


Homo sapiens

Features
Gene ID: ENSG00000138600
  
Biological name :SPPL2A
  
Synonyms : Q8TCT8 / signal peptide peptidase like 2A / SPPL2A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q21.2
Gene start: 50702266
Gene end: 50765808
  
Corresponding Affymetrix probe sets: 226353_at (Human Genome U133 Plus 2.0 Array)   227682_at (Human Genome U133 Plus 2.0 Array)   228478_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000261854
Ensembl peptide - ENSP00000453927
Ensembl peptide - ENSP00000453932
NCBI entrez gene - 84888     See in Manteia.
OMIM - 608238
RefSeq - XM_017022681
RefSeq - NM_032802
RefSeq - XM_005254722
RefSeq - XM_017022680
RefSeq Peptide - NP_116191
swissprot - Q8TCT8
swissprot - H0YNA7
swissprot - H0YNA2
Ensembl - ENSG00000138600
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SPPL2AENSGALG00000031348Gallus gallus
 Q9JJF9ENSMUSG00000027366Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8TCT7 / SPPL2B / signal peptide peptidase like 2BENSG0000000520646
Q8IUH8 / SPPL2C / signal peptide peptidase like 2CENSG0000018529440
HM13 / Q8TCT9 / histocompatibility minor 13ENSG0000010129416
SPPL3 / Q8TCT6 / signal peptide peptidase like 3ENSG0000015783715


Protein motifs (from Interpro)
Interpro ID Name
 IPR003137  PA domain
 IPR006639  Presenilin/signal peptide peptidase
 IPR007369  Peptidase A22B, signal peptide peptidase
 IPR033151  Signal peptide peptidase-like 2a


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006509 membrane protein ectodomain proteolysis IDA
 biological_processGO:0010803 regulation of tumor necrosis factor-mediated signaling pathway TAS
 biological_processGO:0031293 membrane protein intracellular domain proteolysis IEA
 biological_processGO:0033619 membrane protein proteolysis IDA
 biological_processGO:0050776 regulation of immune response IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005770 late endosome IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030660 Golgi-associated vesicle membrane IDA
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane IDA
 cellular_componentGO:0071556 integral component of lumenal side of endoplasmic reticulum membrane IDA
 molecular_functionGO:0004190 aspartic-type endopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042500 aspartic endopeptidase activity, intramembrane cleaving IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
Regulation of TNFR1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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