ENSMUSG00000027366


Mus musculus

Features
Gene ID: ENSMUSG00000027366
  
Biological name :Sppl2a
  
Synonyms : Q9JJF9 / signal peptide peptidase like 2A / Sppl2a
  
Possible biological names infered from orthology : Q8TCT8
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: F1
Gene start: 126890391
Gene end: 126933235
  
Corresponding Affymetrix probe sets: 10487321 (MoGene1.0st)   1425193_at (Mouse Genome 430 2.0 Array)   1450459_at (Mouse Genome 430 2.0 Array)   1452225_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028844
Ensembl peptide - ENSMUSP00000119064
NCBI entrez gene - 66552     See in Manteia.
MGI - MGI:1913802
RefSeq - XM_017319184
RefSeq - NM_023220
RefSeq - XM_017319181
RefSeq - XM_017319182
RefSeq - XM_017319183
RefSeq - XM_011239735
RefSeq - XM_011239737
RefSeq - XM_017319180
RefSeq Peptide - NP_075709
swissprot - Q9JJF9
swissprot - F6RJQ8
Ensembl - ENSMUSG00000027366
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SPPL2AENSGALG00000031348Gallus gallus
 Q8TCT8ENSG00000138600Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3TD49 / Sppl2b / Signal peptide peptidase-like 2B / Q8TCT7*ENSMUSG0000003520644
A2A6C4 / Sppl2c / Signal peptide peptidase-like 2C / Q8IUH8*ENSMUSG0000004950639
H13 / Q9D8V0 / Minor histocompatibility antigen H13 / HM13* / Q8TCT9* / histocompatibility minor 13*ENSMUSG0000001918816
Sppl3 / Q9CUS9 / Signal peptide peptidase-like 3 / Q8TCT6*ENSMUSG0000002955015


Protein motifs (from Interpro)
Interpro ID Name
 IPR003137  PA domain
 IPR006639  Presenilin/signal peptide peptidase
 IPR007369  Peptidase A22B, signal peptide peptidase
 IPR033151  Signal peptide peptidase-like 2a


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006509 membrane protein ectodomain proteolysis IEA
 biological_processGO:0031293 membrane protein intracellular domain proteolysis IEA
 biological_processGO:0033619 membrane protein proteolysis IEA
 biological_processGO:0050776 regulation of immune response IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030660 Golgi-associated vesicle membrane IEA
 cellular_componentGO:0031902 late endosome membrane IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane IEA
 cellular_componentGO:0071556 integral component of lumenal side of endoplasmic reticulum membrane IEA
 molecular_functionGO:0004190 aspartic-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042500 aspartic endopeptidase activity, intramembrane cleaving IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Regulation of TNFR1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: L1camtm4.1Vlem/Y
Genetic Background: either: 129S4.129S2-L1camtm4.1Vlem or B6.129S4-L1camtm4.1Vlem

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz,Sppl2atm1Dgen/Sppl2atm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
Show

Allelic Composition: Sppl2atm1Basc/Sppl2atm1Basc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ern2m3Btlr/Ern2m3Btlr
Genetic Background: C57BL/6J-Ern2m3Btlr

Allelic Composition: Sppl2am2Btlr/Sppl2am2Btlr
Genetic Background: C57BL/6J-Sppl2am2Btlr

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Edardl-J/Edartm1.1Bamo
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * FVB/N

Allelic Composition: Sppl2achompB/Sppl2achompB
Genetic Background: involves: C57BL/6

Allelic Composition: Sppl2atm1Basc/Sppl2atm1Basc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

Allelic Composition: Sppl2am1Anu/Sppl2am1Anu
Genetic Background: involves: C57BL/6JAnu

Allelic Composition: Sppl2am2Btlr/Sppl2am2Btlr
Genetic Background: C57BL/6J-Sppl2am2Btlr

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Edardl-J/Edartm1.1Bamo
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * FVB/N

Allelic Composition: Sppl2atm1Basc/Sppl2atm1Basc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: L1camtm4.1Vlem/Y
Genetic Background: either: 129S4.129S2-L1camtm4.1Vlem or B6.129S4-L1camtm4.1Vlem

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kcnj10tm1Lst/Kcnj10tm1Lst
Genetic Background: involves: 129S1/Sv

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Raxtm1.1(rTA,tetO-cre)Lan/?
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sppl2achompB/Sppl2achompB
Genetic Background: involves: C57BL/6

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Edardl-J/Edartm1.1Bamo
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * FVB/N

Allelic Composition: Sppl2atm1Basc/Sppl2atm1Basc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Edardl-J/Edartm1.1Bamo
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * FVB/N

Allelic Composition: Sppl2atm1Basc/Sppl2atm1Basc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz,Sppl2atm1Basc/Sppl2atm1Basc
Genetic Background: B6.129-Sppl2atm1Basc Cd74tm1Liz

Allelic Composition: Sppl2atm1Basc/Sppl2atm1Basc,Sppl2bGt(Ayu21-T160)Imeg/Sppl2bGt(Ayu21-T160)Imeg
Genetic Background: B6N.Cg-Sppl2atm1Basc Sppl2bGt(Ayu21-T160)Imeg

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sppl2atm1Basc/Sppl2atm1Basc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Sppl2am1Anu/Sppl2am1Anu
Genetic Background: involves: C57BL/6JAnu

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sppl2achompB/Sppl2achompB
Genetic Background: involves: C57BL/6

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sppl2am1Anu/Sppl2am1Anu
Genetic Background: involves: C57BL/6JAnu

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sppl2am1Anu/Sppl2am1Anu
Genetic Background: involves: C57BL/6JAnu

 MP:0008122 decreased myeloid dendritic cell number "reduction in the number of phagocytic cells of the myeloid lineage that capture antigens in the periphery and then migrate to the lymphoid organs and secrete cytokines to initiate immune responses" [PMID:10449155, PMID:9521319]
Show

Allelic Composition: Edardl-J/Edartm1.1Bamo
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * FVB/N

Allelic Composition: Sppl2achompB/Sppl2achompB
Genetic Background: involves: C57BL/6

 MP:0008124 decreased plasmacytoid dendritic cell number "reduced number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15596797]
Show

Allelic Composition: Sppl2achompB/Sppl2achompB
Genetic Background: involves: C57BL/6

 MP:0008133 decreased Peyer s patch number "reduction in the number of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
Show

Allelic Composition: Sppl2atm1Basc/Sppl2atm1Basc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz,Sppl2atm1Basc/Sppl2atm1Basc
Genetic Background: B6.129-Sppl2atm1Basc Cd74tm1Liz

 MP:0008135 small Peyer s patches "reduced size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
Show

Allelic Composition: Sppl2atm1Basc/Sppl2atm1Basc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

 MP:0008171 abnormal mature B cell morphology "any structural anomaly of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sppl2am1Anu/Sppl2am1Anu
Genetic Background: involves: C57BL/6JAnu

Allelic Composition: Sppl2atm1Basc/Sppl2atm1Basc,Sppl2bGt(Ayu21-T160)Imeg/Sppl2bGt(Ayu21-T160)Imeg
Genetic Background: B6N.Cg-Sppl2atm1Basc Sppl2bGt(Ayu21-T160)Imeg

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Edardl-J/Edartm1.1Bamo
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * FVB/N

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz,Sppl2atm1Dgen/Sppl2atm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

Allelic Composition: Sppl2achompB/Sppl2achompB
Genetic Background: involves: C57BL/6

Allelic Composition: Sppl2atm1Basc/Sppl2atm1Basc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Sppl2achompB/Sppl2achompB
Genetic Background: involves: C57BL/6

Allelic Composition: Sppl2atm1Basc/Sppl2atm1Basc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

Allelic Composition: Sppl2am1Anu/Sppl2am1Anu
Genetic Background: involves: C57BL/6JAnu

 MP:0008188 abnormal transitional stage B cell morphology "any structural anomaly of an immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sppl2am1Anu/Sppl2am1Anu
Genetic Background: involves: C57BL/6JAnu

 MP:0008207 decreased B-2 cell number "reduced number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Sppl2atm1Basc/Sppl2atm1Basc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

 MP:0008210 increased mature B cell number "greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Sppl2am1Anu/Sppl2am1Anu
Genetic Background: involves: C57BL/6JAnu

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Sppl2achompB/Sppl2achompB
Genetic Background: involves: C57BL/6

Allelic Composition: Sppl2atm1Basc/Sppl2atm1Basc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Edardl-J/Edartm1.1Bamo
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * FVB/N

Allelic Composition: Sppl2achompB/Sppl2achompB
Genetic Background: involves: C57BL/6

Allelic Composition: Sppl2atm1Basc/Sppl2atm1Basc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

Allelic Composition: Sppl2am1Anu/Sppl2am1Anu
Genetic Background: involves: C57BL/6JAnu

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Sppl2atm1Basc/Sppl2atm1Basc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Edardl-J/Edartm1.1Bamo
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * FVB/N

Allelic Composition: Sppl2achompB/Sppl2achompB
Genetic Background: involves: C57BL/6

Allelic Composition: Sppl2atm1Basc/Sppl2atm1Basc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Edardl-J/Edartm1.1Bamo
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * FVB/N

Allelic Composition: Sppl2achompB/Sppl2achompB
Genetic Background: involves: C57BL/6

Allelic Composition: Sppl2atm1Basc/Sppl2atm1Basc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

 MP:0008524 increased plasmacytoid dendritic cell number "greater number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15596797]
Show

Allelic Composition: Sppl2am1Anu/Sppl2am1Anu
Genetic Background: involves: C57BL/6JAnu

 MP:0009926 decreased transitional stage T2 B cell number "reduced number of a type of transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles" [PMID:12810111]
Show

Allelic Composition: Edardl-J/Edartm1.1Bamo
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * FVB/N

Allelic Composition: Sppl2achompB/Sppl2achompB
Genetic Background: involves: C57BL/6

Allelic Composition: Sppl2atm1Basc/Sppl2atm1Basc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

Allelic Composition: Sppl2am1Anu/Sppl2am1Anu
Genetic Background: involves: C57BL/6JAnu

 MP:0010228 decreased transitional stage T3 B cell number "reduced number of a type of a transitional stage B cell that expresses surface IgM and IgD, and CD62L; it is an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, and CD62L-positive" [PMID:12810111]
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Allelic Composition: Sppl2am1Anu/Sppl2am1Anu
Genetic Background: involves: C57BL/6JAnu

 MP:0010675 decreased activation-induced B cell apoptosis "decreased frequency of B cell apoptosis that occurs upon engagement of either the B cell receptor or CD40, but not both; the engagement leads to expression of fas or related receptors that make the B cell susceptible to fas-ligand mediated death" [PMID:11032170]
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Allelic Composition: Sppl2achompB/Sppl2achompB
Genetic Background: involves: C57BL/6

 MP:0020001 decreased response to antigen "decreased or weak immune response after exposure to an antigen" [GOC:NV]
Show

Allelic Composition: Ern2m3Btlr/Ern2m3Btlr
Genetic Background: C57BL/6J-Ern2m3Btlr

Allelic Composition: Sppl2am2Btlr/Sppl2am2Btlr
Genetic Background: C57BL/6J-Sppl2am2Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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