ENSMUSG00000035206


Mus musculus

Features
Gene ID: ENSMUSG00000035206
  
Biological name :Sppl2b
  
Synonyms : Q3TD49 / Signal peptide peptidase-like 2B / Sppl2b
  
Possible biological names infered from orthology : Q8TCT7
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 80855275
Gene end: 80868708
  
Corresponding Affymetrix probe sets: 10364916 (MoGene1.0st)   1434658_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152014
Ensembl peptide - ENSMUSP00000036289
Ensembl peptide - ENSMUSP00000151420
Ensembl peptide - ENSMUSP00000151531
Ensembl peptide - ENSMUSP00000151737
NCBI entrez gene - 73218     See in Manteia.
MGI - MGI:1920468
RefSeq - XM_017314121
RefSeq - XM_006514213
RefSeq - XM_006514214
RefSeq - XM_006514215
RefSeq - XM_011243585
RefSeq - XM_017314119
RefSeq - XM_017314120
RefSeq - NM_175195
RefSeq - XM_006514209
RefSeq - XM_006514210
RefSeq - XM_006514211
RefSeq - XM_006514212
RefSeq Peptide - NP_780404
swissprot - A0A1W2P8D1
swissprot - A0A1W2P7P8
swissprot - A0A1W2P794
swissprot - A0A1W2P6U2
swissprot - Q3TD49
Ensembl - ENSMUSG00000035206
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sppl2ENSDARG00000030448Danio rerio
 SPPL2BENSGALG00000000430Gallus gallus
 Q8TCT7ENSG00000005206Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A2A6C4 / Sppl2c / Signal peptide peptidase-like 2C / Q8IUH8*ENSMUSG0000004950648
Q9JJF9 / Sppl2a / signal peptide peptidase like 2A / Q8TCT8*ENSMUSG0000002736640
Sppl3 / Q9CUS9 / Signal peptide peptidase-like 3 / Q8TCT6*ENSMUSG0000002955016
H13 / Q9D8V0 / Minor histocompatibility antigen H13 / HM13* / Q8TCT9* / histocompatibility minor 13*ENSMUSG0000001918815


Protein motifs (from Interpro)
Interpro ID Name
 IPR003137  PA domain
 IPR006639  Presenilin/signal peptide peptidase
 IPR007369  Peptidase A22B, signal peptide peptidase
 IPR033149  Signal peptidase peptidase-like 2B


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006509 membrane protein ectodomain proteolysis IEA
 biological_processGO:0031293 membrane protein intracellular domain proteolysis IEA
 biological_processGO:0033619 membrane protein proteolysis IEA
 biological_processGO:0050776 regulation of immune response IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane ISO
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0010008 endosome membrane ISS
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030660 Golgi-associated vesicle membrane IEA
 cellular_componentGO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane IEA
 cellular_componentGO:0071556 integral component of lumenal side of endoplasmic reticulum membrane IEA
 molecular_functionGO:0004190 aspartic-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042500 aspartic endopeptidase activity, intramembrane cleaving IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Regulation of TNFR1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kcnj10tm1Lst/Kcnj10tm1Lst
Genetic Background: involves: 129S1/Sv

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sppl2atm1Basc/Sppl2atm1Basc,Sppl2bGt(Ayu21-T160)Imeg/Sppl2bGt(Ayu21-T160)Imeg
Genetic Background: B6N.Cg-Sppl2atm1Basc Sppl2bGt(Ayu21-T160)Imeg

 MP:0008171 abnormal mature B cell morphology "any structural anomaly of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sppl2atm1Basc/Sppl2atm1Basc,Sppl2bGt(Ayu21-T160)Imeg/Sppl2bGt(Ayu21-T160)Imeg
Genetic Background: B6N.Cg-Sppl2atm1Basc Sppl2bGt(Ayu21-T160)Imeg

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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