ENSMUSG00000029550


Mus musculus

Features
Gene ID: ENSMUSG00000029550
  
Biological name :Sppl3
  
Synonyms : Q9CUS9 / Signal peptide peptidase-like 3 / Sppl3
  
Possible biological names infered from orthology : Q8TCT6
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: F
Gene start: 115011137
Gene end: 115098790
  
Corresponding Affymetrix probe sets: 10524647 (MoGene1.0st)   1423658_at (Mouse Genome 430 2.0 Array)   1451073_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143889
Ensembl peptide - ENSMUSP00000031530
NCBI entrez gene - 74585     See in Manteia.
MGI - MGI:1891433
RefSeq - NM_029012
RefSeq - XM_017321123
RefSeq Peptide - NP_083288
swissprot - A0A0J9YTX1
swissprot - Q9CUS9
Ensembl - ENSMUSG00000029550
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sppl3ENSDARG00000025220Danio rerio
 SPPL3ENSGALG00000006979Gallus gallus
 SPPL3ENSG00000157837Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3TD49 / Sppl2b / Signal peptide peptidase-like 2B / Q8TCT7*ENSMUSG0000003520624
A2A6C4 / Sppl2c / Signal peptide peptidase-like 2C / Q8IUH8*ENSMUSG0000004950624
H13 / Q9D8V0 / Minor histocompatibility antigen H13 / HM13* / Q8TCT9* / histocompatibility minor 13*ENSMUSG0000001918823
Q9JJF9 / Sppl2a / signal peptide peptidase like 2A / Q8TCT8*ENSMUSG0000002736620


Protein motifs (from Interpro)
Interpro ID Name
 IPR006639  Presenilin/signal peptide peptidase
 IPR007369  Peptidase A22B, signal peptide peptidase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IDA
 biological_processGO:0032092 positive regulation of protein binding IDA
 biological_processGO:0033619 membrane protein proteolysis IEA
 biological_processGO:0035307 positive regulation of protein dephosphorylation IEA
 biological_processGO:0050852 T cell receptor signaling pathway IEA
 biological_processGO:0070886 positive regulation of calcineurin-NFAT signaling cascade IEA
 cellular_componentGO:0005765 lysosomal membrane IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030660 Golgi-associated vesicle membrane IEA
 cellular_componentGO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane IEA
 cellular_componentGO:0071556 integral component of lumenal side of endoplasmic reticulum membrane IEA
 molecular_functionGO:0004190 aspartic-type endopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042500 aspartic endopeptidase activity, intramembrane cleaving IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoftm1(KOMP)Vlcg/Apof+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Apoftm1(KOMP)Vlcg/Apof+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: Apoftm1(KOMP)Vlcg/Apof+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
Show

Allelic Composition: Apoftm1(KOMP)Vlcg/Apof+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoftm1(KOMP)Vlcg/Apof+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Apoftm1(KOMP)Vlcg/Apof+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0003360 depression-related behavior 
Show

Allelic Composition: Apoftm1(KOMP)Vlcg/Apof+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Apoftm1(KOMP)Vlcg/Apof+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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