ENSG00000157837


Homo sapiens

Features
Gene ID: ENSG00000157837
  
Biological name :SPPL3
  
Synonyms : Q8TCT6 / signal peptide peptidase like 3 / SPPL3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q24.31
Gene start: 120762510
Gene end: 120904371
  
Corresponding Affymetrix probe sets: 1554564_a_at (Human Genome U133 Plus 2.0 Array)   1554565_x_at (Human Genome U133 Plus 2.0 Array)   224638_at (Human Genome U133 Plus 2.0 Array)   224639_at (Human Genome U133 Plus 2.0 Array)   224640_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000446088
Ensembl peptide - ENSP00000442484
Ensembl peptide - ENSP00000444821
Ensembl peptide - ENSP00000288680
Ensembl peptide - ENSP00000437603
Ensembl peptide - ENSP00000439390
NCBI entrez gene - 121665     See in Manteia.
OMIM - 608240
RefSeq - XM_011537925
RefSeq - NM_139015
RefSeq Peptide - NP_620584
swissprot - F5H6I1
swissprot - F5H7J2
swissprot - F5H4Y6
swissprot - Q8TCT6
swissprot - F5H4L1
swissprot - F5H2A2
Ensembl - ENSG00000157837
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sppl3ENSDARG00000025220Danio rerio
 SPPL3ENSGALG00000006979Gallus gallus
 Sppl3ENSMUSG00000029550Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8TCT7 / SPPL2B / signal peptide peptidase like 2BENSG0000000520625
Q8IUH8 / SPPL2C / signal peptide peptidase like 2CENSG0000018529424
HM13 / Q8TCT9 / histocompatibility minor 13ENSG0000010129423
Q8TCT8 / SPPL2A / signal peptide peptidase like 2AENSG0000013860021


Protein motifs (from Interpro)
Interpro ID Name
 IPR006639  Presenilin/signal peptide peptidase
 IPR007369  Peptidase A22B, signal peptide peptidase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0033619 membrane protein proteolysis IDA
 biological_processGO:0035307 positive regulation of protein dephosphorylation IMP
 biological_processGO:0050852 T cell receptor signaling pathway IEA
 biological_processGO:0070886 positive regulation of calcineurin-NFAT signaling cascade IMP
 cellular_componentGO:0005765 lysosomal membrane IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IDA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030660 Golgi-associated vesicle membrane IDA
 cellular_componentGO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane IDA
 cellular_componentGO:0071556 integral component of lumenal side of endoplasmic reticulum membrane IDA
 molecular_functionGO:0004190 aspartic-type endopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042500 aspartic endopeptidase activity, intramembrane cleaving IMP
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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