ENSG00000005206


Homo sapiens

Features
Gene ID: ENSG00000005206
  
Biological name :SPPL2B
  
Synonyms : Q8TCT7 / signal peptide peptidase like 2B / SPPL2B
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.3
Gene start: 2328615
Gene end: 2354806
  
Corresponding Affymetrix probe sets: 210693_at (Human Genome U133 Plus 2.0 Array)   215833_s_at (Human Genome U133 Plus 2.0 Array)   225248_at (Human Genome U133 Plus 2.0 Array)   225249_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000478298
Ensembl peptide - ENSP00000482470
Ensembl peptide - ENSP00000482362
Ensembl peptide - ENSP00000480813
Ensembl peptide - ENSP00000480311
Ensembl peptide - ENSP00000478510
Ensembl peptide - ENSP00000477658
NCBI entrez gene - 56928     See in Manteia.
OMIM - 608239
RefSeq - XM_011528139
RefSeq - XM_017027018
RefSeq - XM_017027017
RefSeq - NM_001077238
RefSeq - NM_152988
RefSeq - XM_017027019
RefSeq - XM_017027016
RefSeq - XM_011528138
RefSeq - XM_011528140
RefSeq Peptide - NP_694533
RefSeq Peptide - NP_001070706
swissprot - Q8TCT7
swissprot - A0A087WZ93
swissprot - A0A087WT77
swissprot - A0A087WWL4
swissprot - A0A087WZ50
Ensembl - ENSG00000005206
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sppl2ENSDARG00000030448Danio rerio
 SPPL2BENSGALG00000000430Gallus gallus
 Q3TD49ENSMUSG00000035206Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8IUH8 / SPPL2C / signal peptide peptidase like 2CENSG0000018529446
Q8TCT8 / SPPL2A / signal peptide peptidase like 2AENSG0000013860041
SPPL3 / Q8TCT6 / signal peptide peptidase like 3ENSG0000015783716
HM13 / Q8TCT9 / histocompatibility minor 13ENSG0000010129415


Protein motifs (from Interpro)
Interpro ID Name
 IPR003137  PA domain
 IPR006639  Presenilin/signal peptide peptidase
 IPR007369  Peptidase A22B, signal peptide peptidase
 IPR033149  Signal peptidase peptidase-like 2B


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006509 membrane protein ectodomain proteolysis IDA
 biological_processGO:0010803 regulation of tumor necrosis factor-mediated signaling pathway TAS
 biological_processGO:0031293 membrane protein intracellular domain proteolysis IEA
 biological_processGO:0033619 membrane protein proteolysis IDA
 biological_processGO:0050776 regulation of immune response IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030660 Golgi-associated vesicle membrane IDA
 cellular_componentGO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane IDA
 cellular_componentGO:0071556 integral component of lumenal side of endoplasmic reticulum membrane IDA
 molecular_functionGO:0004190 aspartic-type endopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042500 aspartic endopeptidase activity, intramembrane cleaving IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
Regulation of TNFR1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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