ENSG00000140451


Homo sapiens

Features
Gene ID: ENSG00000140451
  
Biological name :PIF1
  
Synonyms : PIF1 / PIF1 5-to-3 DNA helicase / Q9H611
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q22.31
Gene start: 64815632
Gene end: 64825668
  
Corresponding Affymetrix probe sets: 1555591_at (Human Genome U133 Plus 2.0 Array)   228252_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000268043
Ensembl peptide - ENSP00000328174
Ensembl peptide - ENSP00000452792
NCBI entrez gene - 80119     See in Manteia.
OMIM - 610953
RefSeq - XM_011522084
RefSeq - NM_001286496
RefSeq - NM_001286497
RefSeq - NM_001286499
RefSeq - NM_025049
RefSeq - XM_011522083
RefSeq Peptide - NP_001273428
RefSeq Peptide - NP_079325
RefSeq Peptide - NP_001273425
RefSeq Peptide - NP_001273426
swissprot - Q9H611
Ensembl - ENSG00000140451
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pif1ENSDARG00000020289Danio rerio
 PIF1ENSGALG00000009032Gallus gallus
 Pif1ENSMUSG00000041064Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003840  DNA helicase
 IPR010285  DNA helicase Pif1-like
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000002 mitochondrial genome maintenance IBA
 biological_processGO:0000723 telomere maintenance IEA
 biological_processGO:0006260 DNA replication IBA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0032204 regulation of telomere maintenance IDA
 biological_processGO:0032211 negative regulation of telomere maintenance via telomerase IDA
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0044806 G-quadruplex DNA unwinding IBA
 biological_processGO:0051974 negative regulation of telomerase activity IDA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005657 replication fork IBA
 cellular_componentGO:0005739 mitochondrion IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003678 DNA helicase activity IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0010521 telomerase inhibitor activity IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017116 single-stranded DNA-dependent ATP-dependent DNA helicase activity IDA
 molecular_functionGO:0033682 ATP-dependent 5"-3" DNA/RNA helicase activity IDA
 molecular_functionGO:0042162 telomeric DNA binding IDA
 molecular_functionGO:0043141 ATP-dependent 5"-3" DNA helicase activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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