ENSMUSG00000041064


Mus musculus

Features
Gene ID: ENSMUSG00000041064
  
Biological name :Pif1
  
Synonyms : Mus musculus PIF1 5-to-3 DNA helicase (Pif1), transcript variant 2, mRNA. / Pif1 / Q80SX8
  
Possible biological names infered from orthology : PIF1 5-to-3 DNA helicase / Q9H611
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: C
Gene start: 65587160
Gene end: 65595967
  
Corresponding Affymetrix probe sets: 10586416 (MoGene1.0st)   1436738_at (Mouse Genome 430 2.0 Array)   1438149_at (Mouse Genome 430 2.0 Array)   1439297_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118742
Ensembl peptide - ENSMUSP00000117494
Ensembl peptide - ENSMUSP00000120400
Ensembl peptide - ENSMUSP00000122060
Ensembl peptide - ENSMUSP00000049046
Ensembl peptide - ENSMUSP00000117085
NCBI entrez gene - 208084     See in Manteia.
MGI - MGI:2143057
RefSeq - XM_011242690
RefSeq - NM_001357526
RefSeq - NM_001357527
RefSeq - NM_172453
RefSeq - XM_006510919
RefSeq - XM_006510920
RefSeq - XM_006510921
RefSeq Peptide - NP_766041
RefSeq Peptide - NP_001344456
RefSeq Peptide - NP_001344455
swissprot - A0A1C7ZMZ4
swissprot - Q80SX8
swissprot - D6RFC6
swissprot - D3YZ87
Ensembl - ENSMUSG00000041064
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pif1ENSDARG00000020289Danio rerio
 PIF1ENSGALG00000009032Gallus gallus
 PIF1ENSG00000140451Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR010285  DNA helicase Pif1-like
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000002 mitochondrial genome maintenance IBA
 biological_processGO:0000723 telomere maintenance IEA
 biological_processGO:0006260 DNA replication IBA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0032204 regulation of telomere maintenance ISO
 biological_processGO:0032211 negative regulation of telomere maintenance via telomerase IBA
 biological_processGO:0032508 DNA duplex unwinding IBA
 biological_processGO:0044806 G-quadruplex DNA unwinding IBA
 biological_processGO:0051974 negative regulation of telomerase activity ISO
 cellular_componentGO:0000784 nuclear chromosome, telomeric region ISO
 cellular_componentGO:0005634 nucleus IMP
 cellular_componentGO:0005657 replication fork IBA
 cellular_componentGO:0005739 mitochondrion IMP
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003678 DNA helicase activity IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0010521 telomerase inhibitor activity IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017116 single-stranded DNA-dependent ATP-dependent DNA helicase activity ISO
 molecular_functionGO:0033682 ATP-dependent 5"-3" DNA/RNA helicase activity ISO
 molecular_functionGO:0042162 telomeric DNA binding ISO
 molecular_functionGO:0043141 ATP-dependent 5"-3" DNA helicase activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Seletm1Roml/Seletm1Roml
Genetic Background: involves: 129S1/Sv

 MP:0003155 abnormal telomere length "abnormal length of the terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability; normal length is a few hundred base pairs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Seletm1Roml/Seletm1Roml
Genetic Background: involves: 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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