ENSG00000140505


Homo sapiens

Features
Gene ID: ENSG00000140505
  
Biological name :CYP1A2
  
Synonyms : CYP1A2 / cytochrome P450 family 1 subfamily A member 2 / P05177
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q24.1
Gene start: 74748844
Gene end: 74756202
  
Corresponding Affymetrix probe sets: 207608_x_at (Human Genome U133 Plus 2.0 Array)   207609_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000342007
NCBI entrez gene - 1544     See in Manteia.
OMIM - 124060
RefSeq - NM_000761
RefSeq Peptide - NP_000752
swissprot - P05177
Ensembl - ENSG00000140505
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp1aENSDARG00000098315Danio rerio
 CYP1A1ENSGALG00000001325Gallus gallus
 CYP1A2ENSGALG00000001320Gallus gallus
 Cyp1a2ENSMUSG00000032310Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CYP1A1 / P04798 / cytochrome P450 family 1 subfamily A member 1ENSG0000014046572
CYP1B1 / Q16678 / cytochrome P450 family 1 subfamily B member 1ENSG0000013806137
CYP2S1 / Q96SQ9 / cytochrome P450 family 2 subfamily S member 1ENSG0000016760027
P05093 / CYP17A1 / cytochrome P450 family 17 subfamily A member 1ENSG0000014879527
P08686 / CYP21A2 / cytochrome P450 family 21 subfamily A member 2ENSG0000023185225


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002401  Cytochrome P450, E-class, group I
 IPR008066  Cytochrome P450, E-class, group I, CYP1
 IPR017972  Cytochrome P450, conserved site
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006706 steroid catabolic process IMP
 biological_processGO:0006725 cellular aromatic compound metabolic process IEA
 biological_processGO:0006778 porphyrin-containing compound metabolic process IEA
 biological_processGO:0006805 xenobiotic metabolic process TAS
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0009403 toxin biosynthetic process IDA
 biological_processGO:0009404 toxin metabolic process IEA
 biological_processGO:0009791 post-embryonic development IEA
 biological_processGO:0009820 alkaloid metabolic process IDA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0016098 monoterpenoid metabolic process IDA
 biological_processGO:0017144 drug metabolic process IEA
 biological_processGO:0018894 dibenzo-p-dioxin metabolic process IEA
 biological_processGO:0019373 epoxygenase P450 pathway TAS
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0032259 methylation TAS
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032787 monocarboxylic acid metabolic process IDA
 biological_processGO:0035902 response to immobilization stress IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042737 drug catabolic process IMP
 biological_processGO:0042738 exogenous drug catabolic process IDA
 biological_processGO:0045333 cellular respiration IEA
 biological_processGO:0046483 heterocycle metabolic process IDA
 biological_processGO:0050665 hydrogen peroxide biosynthetic process IEA
 biological_processGO:0055114 oxidation-reduction process IDA
 biological_processGO:0070989 oxidative demethylation IDA
 biological_processGO:0071276 cellular response to cadmium ion IEA
 biological_processGO:0071280 cellular response to copper ion IEA
 biological_processGO:0071615 oxidative deethylation IDA
 biological_processGO:0097267 omega-hydroxylase P450 pathway TAS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004497 monooxygenase activity IDA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0009055 electron transfer activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IDA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IMP
 molecular_functionGO:0019825 oxygen binding TAS
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0020037 heme binding IDA
 molecular_functionGO:0032451 demethylase activity IDA
 molecular_functionGO:0034875 caffeine oxidase activity IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070330 aromatase activity IEA


Pathways (from Reactome)
Pathway description
Methylation
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
Aflatoxin activation and detoxification
Biosynthesis of protectins
Biosynthesis of maresin-like SPMs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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