ENSG00000140465


Homo sapiens

Features
Gene ID: ENSG00000140465
  
Biological name :CYP1A1
  
Synonyms : CYP1A1 / cytochrome P450 family 1 subfamily A member 1 / P04798
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q24.1
Gene start: 74719542
Gene end: 74725610
  
Corresponding Affymetrix probe sets: 205749_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000455846
Ensembl peptide - ENSP00000456585
Ensembl peptide - ENSP00000482863
Ensembl peptide - ENSP00000479744
Ensembl peptide - ENSP00000457668
Ensembl peptide - ENSP00000369050
Ensembl peptide - ENSP00000378488
Ensembl peptide - ENSP00000378489
Ensembl peptide - ENSP00000455051
Ensembl peptide - ENSP00000455340
NCBI entrez gene - 1543     See in Manteia.
OMIM - 108330
RefSeq - NM_001319216
RefSeq - XM_017021953
RefSeq - NM_001319217
RefSeq - NM_000499
RefSeq Peptide - NP_000490
RefSeq Peptide - NP_001306145
RefSeq Peptide - NP_001306146
swissprot - Q5J9B1
swissprot - A4F3V8
swissprot - P04798
swissprot - A0N0X8
swissprot - E7EMT5
Ensembl - ENSG00000140465
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp1aENSDARG00000098315Danio rerio
 CYP1A1ENSGALG00000001325Gallus gallus
 CYP1A2ENSGALG00000001320Gallus gallus
 Cyp1a1ENSMUSG00000032315Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CYP1A2 / P05177 / cytochrome P450 family 1 subfamily A member 2ENSG0000014050572
CYP1B1 / Q16678 / cytochrome P450 family 1 subfamily B member 1ENSG0000013806138
P05093 / CYP17A1 / cytochrome P450 family 17 subfamily A member 1ENSG0000014879530
CYP2S1 / Q96SQ9 / cytochrome P450 family 2 subfamily S member 1ENSG0000016760027
P08686 / CYP21A2 / cytochrome P450 family 21 subfamily A member 2ENSG0000023185225


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002401  Cytochrome P450, E-class, group I
 IPR008066  Cytochrome P450, E-class, group I, CYP1
 IPR017972  Cytochrome P450, conserved site
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001889 liver development IEA
 biological_processGO:0002933 lipid hydroxylation IDA
 biological_processGO:0006778 porphyrin-containing compound metabolic process IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008202 steroid metabolic process IDA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0009308 amine metabolic process IEA
 biological_processGO:0009404 toxin metabolic process IEA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0009624 response to nematode IEA
 biological_processGO:0009635 response to herbicide IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0009692 ethylene metabolic process TAS
 biological_processGO:0009804 coumarin metabolic process IEA
 biological_processGO:0009812 flavonoid metabolic process IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010041 response to iron(III) ion IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0017143 insecticide metabolic process IEA
 biological_processGO:0017144 drug metabolic process IDA
 biological_processGO:0018894 dibenzo-p-dioxin metabolic process IEA
 biological_processGO:0019216 regulation of lipid metabolic process TAS
 biological_processGO:0019341 dibenzo-p-dioxin catabolic process IEA
 biological_processGO:0019373 epoxygenase P450 pathway TAS
 biological_processGO:0032094 response to food IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032502 developmental process IEA
 biological_processGO:0033189 response to vitamin A IEA
 biological_processGO:0035902 response to immobilization stress IEA
 biological_processGO:0042359 vitamin D metabolic process IC
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042904 9-cis-retinoic acid biosynthetic process IEA
 biological_processGO:0043010 camera-type eye development IEA
 biological_processGO:0046483 heterocycle metabolic process IEA
 biological_processGO:0046677 response to antibiotic IEA
 biological_processGO:0046685 response to arsenic-containing substance IEA
 biological_processGO:0048565 digestive tract development IEA
 biological_processGO:0050665 hydrogen peroxide biosynthetic process IEA
 biological_processGO:0055093 response to hyperoxia IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060137 maternal process involved in parturition IEA
 biological_processGO:0070365 hepatocyte differentiation IEA
 biological_processGO:0070988 demethylation IEA
 biological_processGO:0071280 cellular response to copper ion IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IDA
 biological_processGO:0097267 omega-hydroxylase P450 pathway TAS
 biological_processGO:1900087 positive regulation of G1/S transition of mitotic cell cycle IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008395 steroid hydroxylase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0016711 flavonoid 3"-monooxygenase activity IEA
 molecular_functionGO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
 molecular_functionGO:0019825 oxygen binding TAS
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0032451 demethylase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070330 aromatase activity IEA
 molecular_functionGO:0070576 vitamin D 24-hydroxylase activity IDA
 molecular_functionGO:0101020 estrogen 16-alpha-hydroxylase activity IDA


Pathways (from Reactome)
Pathway description
PPARA activates gene expression
Xenobiotics
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
Biosynthesis of protectins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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