ENSMUSG00000032315


Mus musculus

Features
Gene ID: ENSMUSG00000032315
  
Biological name :Cyp1a1
  
Synonyms : Cyp1a1 / Cytochrome P450 1A1 / P00184
  
Possible biological names infered from orthology : cytochrome P450 family 1 subfamily A member 1 / P04798
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: B
Gene start: 57687928
Gene end: 57703824
  
Corresponding Affymetrix probe sets: 10585749 (MoGene1.0st)   1422217_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034865
Ensembl peptide - ENSMUSP00000150277
NCBI entrez gene - 13076     See in Manteia.
MGI - MGI:88588
RefSeq - XM_006510810
RefSeq - NM_001136059
RefSeq - NM_009992
RefSeq Peptide - NP_034122
RefSeq Peptide - NP_001129531
swissprot - P00184
swissprot - Q05A20
Ensembl - ENSMUSG00000032315
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp1aENSDARG00000098315Danio rerio
 CYP1A1ENSGALG00000001325Gallus gallus
 CYP1A2ENSGALG00000001320Gallus gallus
 CYP1A1ENSG00000140465Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cyp1a2 / P00186 / Cytochrome P450 1A2 / P05177* / cytochrome P450 family 1 subfamily A member 2*ENSMUSG0000003231070
Cyp1b1 / Q64429 / Cytochrome P450 1B1 / Q16678* / cytochrome P450 family 1 subfamily B member 1*ENSMUSG0000002408739
P27786 / Cyp17a1 / Steroid 17-alpha-hydroxylase/17,20 lyase / P05093* / cytochrome P450 family 17 subfamily A member 1*ENSMUSG0000000355529
Cyp2c68 / cytochrome P450, family 2, subfamily c, polypeptide 68ENSMUSG0000007488228
Cyp2c67 / cytochrome P450, family 2, subfamily c, polypeptide 67ENSMUSG0000006262427
Cyp2t4 / cytochrome P450, family 2, subfamily t, polypeptide 4ENSMUSG0000007878726
Cyp2s1 / Q9DBX6 / Cytochrome P450 2S1 / Q96SQ9* / cytochrome P450 family 2 subfamily S member 1*ENSMUSG0000004070326
Cyp21a1 / P08686* / CYP21A2* / cytochrome P450 family 21 subfamily A member 2*ENSMUSG0000002436525
Cyp2ab1 / cytochrome P450, family 2, subfamily ab, polypeptide 1ENSMUSG0000002281815


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002401  Cytochrome P450, E-class, group I
 IPR008066  Cytochrome P450, E-class, group I, CYP1
 IPR017972  Cytochrome P450, conserved site
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001889 liver development IEA
 biological_processGO:0002933 lipid hydroxylation ISO
 biological_processGO:0006778 porphyrin-containing compound metabolic process IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008202 steroid metabolic process ISO
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0009308 amine metabolic process IMP
 biological_processGO:0009404 toxin metabolic process IMP
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0009624 response to nematode IEA
 biological_processGO:0009635 response to herbicide IEA
 biological_processGO:0009636 response to toxic substance IMP
 biological_processGO:0009804 coumarin metabolic process IEA
 biological_processGO:0009812 flavonoid metabolic process IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010041 response to iron(III) ion IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0017143 insecticide metabolic process IEA
 biological_processGO:0017144 drug metabolic process ISO
 biological_processGO:0018894 dibenzo-p-dioxin metabolic process IEA
 biological_processGO:0019341 dibenzo-p-dioxin catabolic process IEA
 biological_processGO:0032094 response to food IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032502 developmental process IEA
 biological_processGO:0033189 response to vitamin A IEA
 biological_processGO:0035902 response to immobilization stress IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042904 9-cis-retinoic acid biosynthetic process IEA
 biological_processGO:0043010 camera-type eye development IEA
 biological_processGO:0046483 heterocycle metabolic process IMP
 biological_processGO:0046677 response to antibiotic IEA
 biological_processGO:0046685 response to arsenic-containing substance IEA
 biological_processGO:0048565 digestive tract development IEA
 biological_processGO:0050665 hydrogen peroxide biosynthetic process IMP
 biological_processGO:0055093 response to hyperoxia IEA
 biological_processGO:0055114 oxidation-reduction process ISO
 biological_processGO:0060137 maternal process involved in parturition IEA
 biological_processGO:0070365 hepatocyte differentiation IEA
 biological_processGO:0070988 demethylation IEA
 biological_processGO:0071280 cellular response to copper ion IEA
 biological_processGO:0071407 cellular response to organic cyclic compound ISO
 biological_processGO:1900087 positive regulation of G1/S transition of mitotic cell cycle IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IBA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004497 monooxygenase activity IDA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008395 steroid hydroxylase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity ISO
 molecular_functionGO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0016711 flavonoid 3"-monooxygenase activity IEA
 molecular_functionGO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IDA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0032451 demethylase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070330 aromatase activity IEA
 molecular_functionGO:0070576 vitamin D 24-hydroxylase activity ISO
 molecular_functionGO:0101020 estrogen 16-alpha-hydroxylase activity ISO


Pathways (from Reactome)
Pathway description
Xenobiotics
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
Biosynthesis of protectins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Agtr1atm2Tma/Agtr1atm2Tma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cyp1a1tm4.1Dwn/Cyp1a1tm4.1Dwn
Genetic Background: B6.129X1-Cyp1a1tm4.1Dwn

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Agtr1atm2Tma/Agtr1atm2Tma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cyp1a1tm4.1Dwn/Cyp1a1tm4.1Dwn
Genetic Background: B6.129X1-Cyp1a1tm4.1Dwn

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Spp1Ric-r/Spp1+
Genetic Background: C57L/J

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Spp1Ric-r/Spp1+
Genetic Background: C57L/J

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Agtr1atm2Tma/Agtr1atm2Tma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spp1Ric-r/Spp1+
Genetic Background: C57L/J

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Spp1Ric-r/Spp1+
Genetic Background: C57L/J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Agtr1atm2Tma/Agtr1atm2Tma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Agtr1atm2Tma/Agtr1atm2Tma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cyp1a1tm1.1Dwn/Cyp1a1tm1.1Dwn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cyp1a1tm4.1Dwn/Cyp1a1tm4.1Dwn
Genetic Background: B6.129X1-Cyp1a1tm4.1Dwn

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Agtr1atm2Tma/Agtr1atm2Tma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cyp1a1tm4.1Dwn/Cyp1a1tm4.1Dwn
Genetic Background: B6.129X1-Cyp1a1tm4.1Dwn

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agtr1atm2Tma/Agtr1atm2Tma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cyp1a1tm4.1Dwn/Cyp1a1tm4.1Dwn
Genetic Background: B6.129X1-Cyp1a1tm4.1Dwn

 MP:0004956 decreased thymus weight "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agtr1atm2Tma/Agtr1atm2Tma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cyp1a1tm4.1Dwn/Cyp1a1tm4.1Dwn
Genetic Background: B6.129X1-Cyp1a1tm4.1Dwn

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Agtr1atm2Tma/Agtr1atm2Tma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cyp1a1tm4.1Dwn/Cyp1a1tm4.1Dwn
Genetic Background: B6.129X1-Cyp1a1tm4.1Dwn

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Agtr1atm2Tma/Agtr1atm2Tma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cyp1a1tm1.1Dwn/Cyp1a1tm1.1Dwn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cyp1a1tm4.1Dwn/Cyp1a1tm4.1Dwn
Genetic Background: B6.129X1-Cyp1a1tm4.1Dwn

 MP:0005563 abnormal hemoglobin content "deviation from the normal total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Agtr1atm2Tma/Agtr1atm2Tma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cyp1a1tm4.1Dwn/Cyp1a1tm4.1Dwn
Genetic Background: B6.129X1-Cyp1a1tm4.1Dwn

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Agtr1atm2Tma/Agtr1atm2Tma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cyp1a1tm4.1Dwn/Cyp1a1tm4.1Dwn
Genetic Background: B6.129X1-Cyp1a1tm4.1Dwn

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctgftm1Mga/Ctgftm1Mga
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtr1atm2Tma/Agtr1atm2Tma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cyp1a1tm3.1Dwn/Cyp1a1tm3.1Dwn
Genetic Background: B6.129X1-Cyp1a1tm3.1Dwn

Allelic Composition: Cyp1a1tm4.1Dwn/Cyp1a1tm4.1Dwn
Genetic Background: B6.129X1-Cyp1a1tm4.1Dwn

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtr1atm2Tma/Agtr1atm2Tma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008875 abnormal pharmacokinetics of xenobiotics "any anomaly in the absorbtion, distribution, metabolism or elimination of a foreign compound" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agtr1atm2Tma/Agtr1atm2Tma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cyp1a1tm4.1Dwn/Cyp1a1tm4.1Dwn
Genetic Background: B6.129X1-Cyp1a1tm4.1Dwn

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtr1atm2Tma/Agtr1atm2Tma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtr1atm2Tma/Agtr1atm2Tma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cyp1a1tm4.1Dwn/Cyp1a1tm4.1Dwn
Genetic Background: B6.129X1-Cyp1a1tm4.1Dwn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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