ENSMUSG00000003555


Mus musculus

Features
Gene ID: ENSMUSG00000003555
  
Biological name :Cyp17a1
  
Synonyms : Cyp17a1 / P27786 / Steroid 17-alpha-hydroxylase/17,20 lyase
  
Possible biological names infered from orthology : cytochrome P450 family 17 subfamily A member 1 / P05093
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C3
Gene start: 46667165
Gene end: 46672974
  
Corresponding Affymetrix probe sets: 10468239 (MoGene1.0st)   1417017_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026012
NCBI entrez gene - 13074     See in Manteia.
MGI - MGI:88586
RefSeq - NM_007809
RefSeq Peptide - NP_031835
swissprot - P27786
swissprot - Q53YJ1
Ensembl - ENSMUSG00000003555
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp17a1ENSDARG00000033566Danio rerio
 CYP17A1ENSGALG00000008121Gallus gallus
 P05093ENSG00000148795Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cyp1a1 / P00184 / Cytochrome P450 1A1 / P04798* / cytochrome P450 family 1 subfamily A member 1*ENSMUSG0000003231530
Cyp21a1 / P08686* / CYP21A2* / cytochrome P450 family 21 subfamily A member 2*ENSMUSG0000002436530
Cyp1a2 / P00186 / Cytochrome P450 1A2 / P05177* / cytochrome P450 family 1 subfamily A member 2*ENSMUSG0000003231029
Cyp1b1 / Q64429 / Cytochrome P450 1B1 / Q16678* / cytochrome P450 family 1 subfamily B member 1*ENSMUSG0000002408726
Cyp2t4 / cytochrome P450, family 2, subfamily t, polypeptide 4ENSMUSG0000007878724
Cyp2c68 / cytochrome P450, family 2, subfamily c, polypeptide 68ENSMUSG0000007488224
Cyp2s1 / Q9DBX6 / Cytochrome P450 2S1 / Q96SQ9* / cytochrome P450 family 2 subfamily S member 1*ENSMUSG0000004070324
Cyp2c67 / cytochrome P450, family 2, subfamily c, polypeptide 67ENSMUSG0000006262423
Cyp2ab1 / cytochrome P450, family 2, subfamily ab, polypeptide 1ENSMUSG0000002281814


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002401  Cytochrome P450, E-class, group I
 IPR017972  Cytochrome P450, conserved site
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0006704 glucocorticoid biosynthetic process IDA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0042446 hormone biosynthetic process IEA
 biological_processGO:0042448 progesterone metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0004508 steroid 17-alpha-monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0020037 heme binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047442 17-alpha-hydroxyprogesterone aldolase activity IEA


Pathways (from Reactome)
Pathway description
Androgen biosynthesis
Glucocorticoid biosynthesis
Endogenous sterols


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Cyb561tm1b(EUCOMM)Wtsi/Cyb561tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cyb561tm1b(EUCOMM)Wtsi/H

 MP:0000198 hypophosphatemia "abnormally low concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cyb561tm1b(EUCOMM)Wtsi/Cyb561tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cyb561tm1b(EUCOMM)Wtsi/H

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: Cyb561tm1b(EUCOMM)Wtsi/Cyb561tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cyb561tm1b(EUCOMM)Wtsi/H

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Acacbtm1.1Dejs/Acacbtm1.1Dejs
Genetic Background: B6.Cg-Acacbtm1.1Dejs

 MP:0002566 abnormal sexual interaction "altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Acacbtm1.1Dejs/Acacbtm1.1Dejs
Genetic Background: B6.Cg-Acacbtm1.1Dejs

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Acacbtm1.1Dejs/Acacbtm1.1Dejs
Genetic Background: B6.Cg-Acacbtm1.1Dejs

 MP:0002780 decreased circulating testosterone level "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Acacbtm1.1Dejs/Acacbtm1.1Dejs
Genetic Background: B6.Cg-Acacbtm1.1Dejs

 MP:0002965 hyperalbuminemia "blood albumin concentration above the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Cyb561tm1b(EUCOMM)Wtsi/Cyb561tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cyb561tm1b(EUCOMM)Wtsi/H

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cyb561tm1b(EUCOMM)Wtsi/Cyb561tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cyb561tm1b(EUCOMM)Wtsi/H

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cyb561tm1b(EUCOMM)Wtsi/Cyb561tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cyb561tm1b(EUCOMM)Wtsi/H

 MP:0003795 abnormal bone structure 
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Allelic Composition: Cyb561tm1b(EUCOMM)Wtsi/Cyb561tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cyb561tm1b(EUCOMM)Wtsi/H

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Cyb561tm1b(EUCOMM)Wtsi/Cyb561tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cyb561tm1b(EUCOMM)Wtsi/H

 MP:0004179 transmission ratio distortion "the occurence of an allele or haplotype in the offspring of an organism at skewed Mendelian ratios" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Acacbtm1.1Dejs/Acacbtm1.1Dejs
Genetic Background: B6.Cg-Acacbtm1.1Dejs

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cyb561tm1b(EUCOMM)Wtsi/Cyb561tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cyb561tm1b(EUCOMM)Wtsi/H

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cyb561tm1b(EUCOMM)Wtsi/Cyb561tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cyb561tm1b(EUCOMM)Wtsi/H

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Cyb561tm1b(EUCOMM)Wtsi/Cyb561tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cyb561tm1b(EUCOMM)Wtsi/H

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
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Allelic Composition: Acacbtm1.1Dejs/Acacbtm1.1Dejs
Genetic Background: B6.Cg-Acacbtm1.1Dejs

 MP:0008995 early reproductive senescence "loss of reproductive capacity occurring at an earlier than expected age" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Acacbtm1.1Dejs/Acacbtm1.1Dejs
Genetic Background: B6.Cg-Acacbtm1.1Dejs

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cyb561tm1b(EUCOMM)Wtsi/Cyb561tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cyb561tm1b(EUCOMM)Wtsi/H

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cyb561tm1b(EUCOMM)Wtsi/Cyb561tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cyb561tm1b(EUCOMM)Wtsi/H

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Mybtm1Cgn/Mybtm1Cgn,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0011385 abnormal testosterone level "anomaly in the concentration of a potent androgen that promotes development of male secondary sex characteristics and the development of spermatozoa and may regulate sexual desire and help maintain bone and muscle health in both males and females" [ISBN:0-683-40008-8]
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Allelic Composition: Acacbtm1.1Dejs/Acacbtm1.1Dejs
Genetic Background: B6.Cg-Acacbtm1.1Dejs

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Cyb561tm1b(EUCOMM)Wtsi/Cyb561tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cyb561tm1b(EUCOMM)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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