ENSMUSG00000024087


Mus musculus

Features
Gene ID: ENSMUSG00000024087
  
Biological name :Cyp1b1
  
Synonyms : Cyp1b1 / Cytochrome P450 1B1 / Q64429
  
Possible biological names infered from orthology : cytochrome P450 family 1 subfamily B member 1 / Q16678
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: E3
Gene start: 79706953
Gene end: 79715041
  
Corresponding Affymetrix probe sets: 10453057 (MoGene1.0st)   1416612_at (Mouse Genome 430 2.0 Array)   1416613_at (Mouse Genome 430 2.0 Array)   1432081_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024894
NCBI entrez gene - 13078     See in Manteia.
MGI - MGI:88590
RefSeq - NM_009994
RefSeq Peptide - NP_034124
swissprot - Q64429
Ensembl - ENSMUSG00000024087
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp1b1ENSDARG00000068934Danio rerio
 CYP1B1ENSGALG00000025822Gallus gallus
 CYP1B1ENSG00000138061Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cyp1a1 / P00184 / Cytochrome P450 1A1 / P04798* / cytochrome P450 family 1 subfamily A member 1*ENSMUSG0000003231538
Cyp1a2 / P00186 / Cytochrome P450 1A2 / P05177* / cytochrome P450 family 1 subfamily A member 2*ENSMUSG0000003231035
Cyp2s1 / Q9DBX6 / Cytochrome P450 2S1 / Q96SQ9* / cytochrome P450 family 2 subfamily S member 1*ENSMUSG0000004070327
Cyp2c68 / cytochrome P450, family 2, subfamily c, polypeptide 68ENSMUSG0000007488226
Cyp2t4 / cytochrome P450, family 2, subfamily t, polypeptide 4ENSMUSG0000007878726
Cyp2c67 / cytochrome P450, family 2, subfamily c, polypeptide 67ENSMUSG0000006262426
P27786 / Cyp17a1 / Steroid 17-alpha-hydroxylase/17,20 lyase / P05093* / cytochrome P450 family 17 subfamily A member 1*ENSMUSG0000000355524
Cyp21a1 / P08686* / CYP21A2* / cytochrome P450 family 21 subfamily A member 2*ENSMUSG0000002436522
Cyp2ab1 / cytochrome P450, family 2, subfamily ab, polypeptide 1ENSMUSG0000002281816


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002401  Cytochrome P450, E-class, group I
 IPR017972  Cytochrome P450, conserved site
 IPR032971  Cytochrome P450 1B1
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0002930 trabecular meshwork development IMP
 biological_processGO:0006725 cellular aromatic compound metabolic process IMP
 biological_processGO:0006805 xenobiotic metabolic process ISO
 biological_processGO:0006809 nitric oxide biosynthetic process IMP
 biological_processGO:0007155 cell adhesion IMP
 biological_processGO:0008202 steroid metabolic process ISO
 biological_processGO:0008210 estrogen metabolic process IDA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress IMP
 biological_processGO:0009404 toxin metabolic process IMP
 biological_processGO:0009636 response to toxic substance IMP
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IMP
 biological_processGO:0019369 arachidonic acid metabolic process IEA
 biological_processGO:0030199 collagen fibril organization IMP
 biological_processGO:0030336 negative regulation of cell migration IMP
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0033629 negative regulation of cell adhesion mediated by integrin IMP
 biological_processGO:0042572 retinol metabolic process IDA
 biological_processGO:0042574 retinal metabolic process IDA
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0043542 endothelial cell migration IMP
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0046427 positive regulation of JAK-STAT cascade IMP
 biological_processGO:0046466 membrane lipid catabolic process IMP
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0061298 retina vasculature development in camera-type eye IMP
 biological_processGO:0061304 retinal blood vessel morphogenesis IMP
 biological_processGO:0070301 cellular response to hydrogen peroxide IMP
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071603 endothelial cell-cell adhesion IMP
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IMP
 cellular_componentGO:0005739 mitochondrion IMP
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004497 monooxygenase activity ISO
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
 molecular_functionGO:0020037 heme binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070330 aromatase activity IEA


Pathways (from Reactome)
Pathway description
Endogenous sterols
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004221 abnormal iridocorneal angle "any structural abnormality of the acute angle occurring between the iris and the cornea at the periphery of the anterior chamber of the eye" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua
Genetic Background: involves: 129 * C57BL/6J * FVB

Allelic Composition: Cyp1b1tm1Gonz/Cyp1b1tm1Gonz
Genetic Background: B6.Cg-Cyp1b1tm1Gonz

Allelic Composition: Cyp1b1tm1Gonz/Cyp1b1tm1Gonz
Genetic Background: 129X1.Cg-Cyp1b1tm1Gonz

Allelic Composition: Cyp1b1tm1Gonz/Cyp1b1tm1Gonz,Tyrc-2J/Tyrc-2J
Genetic Background: B6.Cg-Tyrc-2J Cyp1b1tm1Gonz

 MP:0004223 hypoplastic trabecular meshwork "reduced size of the pore-like structure surrounding the entire circumference of the anterior chamber through which aqueous humor circulates" [MESH:A09.371.060.932, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cyp1b1tm1Gonz/Cyp1b1tm1Gonz
Genetic Background: B6.Cg-Cyp1b1tm1Gonz

Allelic Composition: Cyp1b1tm1Gonz/Cyp1b1tm1Gonz
Genetic Background: 129X1.Cg-Cyp1b1tm1Gonz

 MP:0004226 absent Schlemm s canal "absence of the vascular structure encircling the anterior chamber of the eye, through which the aqueous humor is returned to the blood circulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua
Genetic Background: involves: 129 * C57BL/6J * FVB

Allelic Composition: Cyp1b1tm1Gonz/Cyp1b1tm1Gonz,Tyrc-2J/Tyrc-2J
Genetic Background: B6.Cg-Tyrc-2J Cyp1b1tm1Gonz

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr3tm4Cxd/Fgfr3+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * NIH Black Swiss * SJL

 MP:0005203 abnormal trabecular meshwork morphology "structural anomaly in the porelike structure surrounding the entire circumference of the anterior chamber through which aqueous humor circulates" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua
Genetic Background: involves: 129 * C57BL/6J * FVB

Allelic Composition: Cyp1b1tm1Gonz/Cyp1b1tm1Gonz,Tyrc-2J/Tyrc-2J
Genetic Background: B6.Cg-Tyrc-2J Cyp1b1tm1Gonz

 MP:0005204 abnormal canal of Schlemm morphology "structural anomaly in the vascular structure encircling the anterior chamber of the eye, through which the aqueous humor is returned to the blood circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua
Genetic Background: involves: 129 * C57BL/6J * FVB

Allelic Composition: Cyp1b1tm1Gonz/Cyp1b1tm1Gonz
Genetic Background: 129X1.Cg-Cyp1b1tm1Gonz

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr3tm4Cxd/Fgfr3+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * NIH Black Swiss * SJL

 MP:0011481 anterior iris synechia "adhesion of the iris to the cornea" [MGI:anna]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua
Genetic Background: involves: 129 * C57BL/6J * FVB

Allelic Composition: Cyp1b1tm1Gonz/Cyp1b1tm1Gonz,Tyrc-2J/Tyrc-2J
Genetic Background: B6.Cg-Tyrc-2J Cyp1b1tm1Gonz

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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