ENSG00000140983


Homo sapiens

Features
Gene ID: ENSG00000140983
  
Biological name :RHOT2
  
Synonyms : Q8IXI1 / ras homolog family member T2 / RHOT2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: p13.3
Gene start: 668086
Gene end: 674174
  
Corresponding Affymetrix probe sets: 221789_x_at (Human Genome U133 Plus 2.0 Array)   222131_x_at (Human Genome U133 Plus 2.0 Array)   65770_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000459564
Ensembl peptide - ENSP00000457852
Ensembl peptide - ENSP00000458136
Ensembl peptide - ENSP00000321971
Ensembl peptide - ENSP00000454307
Ensembl peptide - ENSP00000454486
Ensembl peptide - ENSP00000455138
Ensembl peptide - ENSP00000456855
Ensembl peptide - ENSP00000457437
NCBI entrez gene - 89941     See in Manteia.
OMIM - 613889
RefSeq - XM_017023842
RefSeq - XM_017023829
RefSeq - XM_017023830
RefSeq - XM_017023831
RefSeq - XM_017023832
RefSeq - XM_017023833
RefSeq - XM_017023834
RefSeq - XM_017023835
RefSeq - XM_017023836
RefSeq - XM_017023837
RefSeq - XM_017023838
RefSeq - XM_017023839
RefSeq - XM_017023840
RefSeq - XM_017023841
RefSeq - NM_001352275
RefSeq - NM_001352280
RefSeq - NM_001352281
RefSeq - NM_001352283
RefSeq - NM_138769
RefSeq - XM_005255660
RefSeq - XM_005255661
RefSeq - XM_005255662
RefSeq - XM_005255663
RefSeq - XM_006720970
RefSeq - XM_006720973
RefSeq - XM_017023825
RefSeq - XM_017023826
RefSeq - XM_017023827
RefSeq - XM_017023828
RefSeq Peptide - NP_001339209
RefSeq Peptide - NP_001339210
RefSeq Peptide - NP_001339212
RefSeq Peptide - NP_620124
RefSeq Peptide - NP_001339204
swissprot - I3L2C6
swissprot - Q8IXI1
swissprot - H3BMP9
swissprot - H3BP40
swissprot - H3BST5
swissprot - H3BU27
swissprot - H3BUX4
swissprot - H3BVI5
Ensembl - ENSG00000140983
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rhot2ENSDARG00000056328Danio rerio
 RHOT2ENSGALG00000002497Gallus gallus
 Gm20683ENSMUSG00000093593Mus musculus
 Rhot2ENSMUSG00000025733Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RHOT1 / Q8IXI2 / ras homolog family member T1ENSG0000012685860


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR002048  EF-hand domain
 IPR005225  Small GTP-binding protein domain
 IPR011992  EF-hand domain pair
 IPR013566  EF hand associated, type-1
 IPR013567  EF hand associated, type-2
 IPR018247  EF-Hand 1, calcium-binding site
 IPR020860  MIRO domain
 IPR021181  Mitochondrial Rho GTPase
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007005 mitochondrion organization IEA
 biological_processGO:0019725 cellular homeostasis IMP
 biological_processGO:0047497 mitochondrion transport along microtubule IMP
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0097345 mitochondrial outer membrane permeabilization IMP
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031307 integral component of mitochondrial outer membrane IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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