ENSMUSG00000025733


Mus musculus

Features
Gene ID: ENSMUSG00000025733
  
Biological name :Rhot2
  
Synonyms : Q8JZN7 / ras homolog family member T2 / Rhot2
  
Possible biological names infered from orthology : Q8IXI1
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.3
Gene start: 25838457
Gene end: 25844851
  
Corresponding Affymetrix probe sets: 10449071 (MoGene1.0st)   1426822_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135611
Ensembl peptide - ENSMUSP00000044639
Ensembl peptide - ENSMUSP00000135436
NCBI entrez gene - 214952     See in Manteia.
MGI - MGI:2384892
RefSeq - NM_145999
RefSeq Peptide - NP_666111
swissprot - Q8JZN7
swissprot - H3BKL2
swissprot - H3BL14
Ensembl - ENSMUSG00000025733
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rhot2ENSDARG00000056328Danio rerio
 RHOT2ENSGALG00000002497Gallus gallus
 RHOT2ENSG00000140983Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm20683 / RHOT2* / Q8IXI1* / ras homolog family member T2*ENSMUSG0000009359366
Rhot1 / Q8BG51 / ras homolog family member T1 / Q8IXI2*ENSMUSG0000001768659


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR013566  EF hand associated, type-1
 IPR013567  EF hand associated, type-2
 IPR018247  EF-Hand 1, calcium-binding site
 IPR020860  MIRO domain
 IPR021181  Mitochondrial Rho GTPase
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007005 mitochondrion organization IEA
 biological_processGO:0019725 cellular homeostasis ISO
 biological_processGO:0047497 mitochondrion transport along microtubule ISS
 biological_processGO:0097345 mitochondrial outer membrane permeabilization ISS
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031307 integral component of mitochondrial outer membrane ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Rhobtb3tm1a(KOMP)Wtsi/Rhobtb3tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Rhobtb3tm1a(KOMP)Wtsi/Wtsi

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Rhobtb3tm1a(KOMP)Wtsi/Rhobtb3tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Rhobtb3tm1a(KOMP)Wtsi/Wtsi

 MP:0004151 hypoferremia "less than the normal concentration of this metallic element in the blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rhobtb3tm1a(KOMP)Wtsi/Rhobtb3tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Rhobtb3tm1a(KOMP)Wtsi/Wtsi

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhobtb3tm1a(KOMP)Wtsi/Rhobtb3tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Rhobtb3tm1a(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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