ENSMUSG00000017686


Mus musculus

Features
Gene ID: ENSMUSG00000017686
  
Biological name :Rhot1
  
Synonyms : Q8BG51 / ras homolog family member T1 / Rhot1
  
Possible biological names infered from orthology : Q8IXI2
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B5
Gene start: 80209019
Gene end: 80267907
  
Corresponding Affymetrix probe sets: 10379410 (MoGene1.0st)   1423533_a_at (Mouse Genome 430 2.0 Array)   1440853_at (Mouse Genome 430 2.0 Array)   1441758_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000076664
Ensembl peptide - ENSMUSP00000017831
Ensembl peptide - ENSMUSP00000057669
Ensembl peptide - ENSMUSP00000090533
Ensembl peptide - ENSMUSP00000117941
NCBI entrez gene - 59040     See in Manteia.
MGI - MGI:1926078
RefSeq - XM_011249168
RefSeq - NM_001163354
RefSeq - NM_001163355
RefSeq - NM_021536
RefSeq - XM_006533886
RefSeq - XM_011249167
RefSeq Peptide - NP_067511
RefSeq Peptide - NP_001156826
RefSeq Peptide - NP_001156827
swissprot - Q8BG51
swissprot - F7ASU3
Ensembl - ENSMUSG00000017686
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6NVC5ENSDARG00000099996Danio rerio
 rhot1bENSDARG00000103313Danio rerio
 RHOT1ENSGALG00000003397Gallus gallus
 RHOT1ENSG00000126858Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rhot2 / Q8JZN7 / ras homolog family member T2 / Q8IXI1*ENSMUSG0000002573354
Gm20683 / RHOT2* / Q8IXI1* / ras homolog family member T2*ENSMUSG0000009359332


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR002048  EF-hand domain
 IPR005225  Small GTP-binding protein domain
 IPR011992  EF-hand domain pair
 IPR013566  EF hand associated, type-1
 IPR013567  EF hand associated, type-2
 IPR018247  EF-Hand 1, calcium-binding site
 IPR020860  MIRO domain
 IPR021181  Mitochondrial Rho GTPase
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007005 mitochondrion organization IEA
 biological_processGO:0019725 cellular homeostasis IEA
 biological_processGO:0034640 establishment of mitochondrion localization by microtubule attachment IEA
 biological_processGO:0046928 regulation of neurotransmitter secretion IEA
 biological_processGO:0047497 mitochondrion transport along microtubule IEA
 biological_processGO:0097345 mitochondrial outer membrane permeabilization IEA
 biological_processGO:1902513 regulation of organelle transport along microtubule IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031307 integral component of mitochondrial outer membrane ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Postn-cre)1Sjc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NTac

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Postn-cre)1Sjc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NTac

 MP:0001078 abnormal phrenic nerve "malformed or misprojection of motor and sensory neuron axons to the diaphragm and other tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Postn-cre)1Sjc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NTac

 MP:0001391 abnormal tail movements "a change from the normal manner of moving the tail" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Postn-cre)1Sjc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NTac

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Postn-cre)1Sjc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NTac

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Postn-cre)1Sjc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NTac

Allelic Composition: Rhot1tm1d(EUCOMM)Wtsi/Rhot1tm1d(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6Dnk * C57BL/6N

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Postn-cre)1Sjc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NTac

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Postn-cre)1Sjc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NTac

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Postn-cre)1Sjc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NTac

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rhot1tm1.1Jmsu/Rhot1tm1.1Jmsu,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Postn-cre)1Sjc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NTac

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Rhot1tm1d(EUCOMM)Wtsi/Rhot1tm1d(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6Dnk * C57BL/6N

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0004768 abnormal axonal transport "any functional anomaly of the directed movement of organelles or vesicles along microtubules in nerve cell axons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

Allelic Composition: Rhot1tm1d(EUCOMM)Wtsi/Rhot1tm1d(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6Dnk * C57BL/6N

 MP:0005277 abnormal brainstem morphology "anomalous structure of the midbrain, pons, or medulla" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82670]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Postn-cre)1Sjc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NTac

Allelic Composition: Rhot1tm1.1Jmsu/Rhot1tm1.1Jmsu,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rhot1tm1d(EUCOMM)Wtsi/Rhot1tm1d(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6Dnk * C57BL/6N

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Postn-cre)1Sjc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NTac

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

Allelic Composition: Rhot1tm1d(EUCOMM)Wtsi/Rhot1tm1d(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6Dnk * C57BL/6N

 MP:0008283 small hippocampus "reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0008415 abnormal neurite morphology "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]
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Allelic Composition: Rhot1tm1d(EUCOMM)Wtsi/Rhot1tm1d(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6Dnk * C57BL/6N

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rhot1tm1.1Jmsu/Rhot1tm1.1Jmsu,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Postn-cre)1Sjc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NTac

Allelic Composition: Rhot1tm1d(EUCOMM)Wtsi/Rhot1tm1d(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6Dnk * C57BL/6N

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
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Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0012051 spasticity "a motor disorder characterized by a velocity-dependent increase in tonic stretch reflexes with increased muscle tone, exaggerated (hyperexcitable) tendon reflexes and increased resistance to stretch" [HP:0001257, MGI:csmith]
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Allelic Composition: Rhot1tm1.1Jmsu/Rhot1tm1.1Jmsu,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029592 Usp30 / Q3UN04 / ubiquitin specific peptidase 30 / Q70CQ3*  / complex






 

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