ENSG00000126858


Homo sapiens

Features
Gene ID: ENSG00000126858
  
Biological name :RHOT1
  
Synonyms : Q8IXI2 / ras homolog family member T1 / RHOT1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q11.2
Gene start: 32142454
Gene end: 32253374
  
Corresponding Affymetrix probe sets: 218323_at (Human Genome U133 Plus 2.0 Array)   222148_s_at (Human Genome U133 Plus 2.0 Array)   224044_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000494075
Ensembl peptide - ENSP00000464851
Ensembl peptide - ENSP00000467272
Ensembl peptide - ENSP00000334724
Ensembl peptide - ENSP00000346215
Ensembl peptide - ENSP00000351132
Ensembl peptide - ENSP00000378184
Ensembl peptide - ENSP00000439737
Ensembl peptide - ENSP00000461992
Ensembl peptide - ENSP00000462612
Ensembl peptide - ENSP00000462669
Ensembl peptide - ENSP00000462698
Ensembl peptide - ENSP00000463532
Ensembl peptide - ENSP00000464094
Ensembl peptide - ENSP00000464674
NCBI entrez gene - 55288     See in Manteia.
OMIM - 613888
RefSeq - XM_017024825
RefSeq - NM_001288754
RefSeq - NM_001288755
RefSeq - NM_001288758
RefSeq - NM_018307
RefSeq - XM_011524969
RefSeq - XM_011524971
RefSeq - XM_011524973
RefSeq - XM_011524975
RefSeq - XM_011524976
RefSeq - XM_017024819
RefSeq - XM_017024820
RefSeq - XM_017024821
RefSeq - XM_017024822
RefSeq - XM_017024823
RefSeq - XM_017024824
RefSeq - NM_001033566
RefSeq - NM_001033567
RefSeq - NM_001033568
RefSeq Peptide - NP_001028739
RefSeq Peptide - NP_001028740
RefSeq Peptide - NP_001275683
RefSeq Peptide - NP_001275684
RefSeq Peptide - NP_001275687
RefSeq Peptide - NP_060777
RefSeq Peptide - NP_001028738
swissprot - J3KRG7
swissprot - Q8IXI2
swissprot - J3KSR5
swissprot - J3QLG2
swissprot - J3QSG2
swissprot - K7EIQ7
swissprot - K7EP86
swissprot - H7BXZ6
Ensembl - ENSG00000126858
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6NVC5ENSDARG00000099996Danio rerio
 rhot1bENSDARG00000103313Danio rerio
 RHOT1ENSGALG00000003397Gallus gallus
 Rhot1ENSMUSG00000017686Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RHOT2 / Q8IXI1 / ras homolog family member T2ENSG0000014098353


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR002048  EF-hand domain
 IPR005225  Small GTP-binding protein domain
 IPR011992  EF-hand domain pair
 IPR013566  EF hand associated, type-1
 IPR013567  EF hand associated, type-2
 IPR018247  EF-Hand 1, calcium-binding site
 IPR020860  MIRO domain
 IPR021181  Mitochondrial Rho GTPase
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007005 mitochondrion organization IEA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0019725 cellular homeostasis IMP
 biological_processGO:0034640 establishment of mitochondrion localization by microtubule attachment IEA
 biological_processGO:0046928 regulation of neurotransmitter secretion IEA
 biological_processGO:0047497 mitochondrion transport along microtubule IMP
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0097345 mitochondrial outer membrane permeabilization IMP
 biological_processGO:1902513 regulation of organelle transport along microtubule IEA
 cellular_componentGO:0005739 mitochondrion NAS
 cellular_componentGO:0005741 mitochondrial outer membrane TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031307 integral component of mitochondrial outer membrane IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000135093 USP30 / Q70CQ3 / ubiquitin specific peptidase 30  / complex






 

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