ENSG00000142089


Homo sapiens

Features
Gene ID: ENSG00000142089
  
Biological name :IFITM3
  
Synonyms : IFITM3 / interferon induced transmembrane protein 3 / Q01628
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: p15.5
Gene start: 319669
Gene end: 327537
  
Corresponding Affymetrix probe sets: 212203_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000432108
Ensembl peptide - ENSP00000473645
Ensembl peptide - ENSP00000473544
Ensembl peptide - ENSP00000382707
NCBI entrez gene - 10410     See in Manteia.
OMIM - 605579
RefSeq - NM_021034
RefSeq Peptide - NP_066362
swissprot - E9PS44
swissprot - Q01628
swissprot - R4GNG9
Ensembl - ENSG00000142089
  
Related genetic diseases (OMIM): 614680 - {Influenza, severe, susceptibility to}, 614680
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IFITM3ENSGALG00000026970Gallus gallus
 Gm45717ENSMUSG00000110104Mus musculus
 Ifitm1ENSMUSG00000025491Mus musculus
 Ifitm2ENSMUSG00000060591Mus musculus
 Ifitm3ENSMUSG00000025492Mus musculus
 Ifitm6ENSMUSG00000059108Mus musculus
 Ifitm7ENSMUSG00000065968Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IFITM2 / Q01629 / interferon induced transmembrane protein 2ENSG0000018520190
IFITM1 / P13164 / interferon induced transmembrane protein 1ENSG0000018588566
A6NMD0 / IFITM10 / interferon induced transmembrane protein 10ENSG0000024424237
A6NNB3 / IFITM5 / interferon induced transmembrane protein 5ENSG0000020601332


Protein motifs (from Interpro)
Interpro ID Name
 IPR007593  CD225/Dispanin family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006955 immune response TAS
 biological_processGO:0009607 response to biotic stimulus IEA
 biological_processGO:0009615 response to virus IDA
 biological_processGO:0032897 negative regulation of viral transcription IDA
 biological_processGO:0034341 response to interferon-gamma IDA
 biological_processGO:0035455 response to interferon-alpha IDA
 biological_processGO:0035456 response to interferon-beta IDA
 biological_processGO:0045071 negative regulation of viral genome replication IDA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0046597 negative regulation of viral entry into host cell IMP
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0060337 type I interferon signaling pathway TAS
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Interferon alpha/beta signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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