ENSMUSG00000025492


Mus musculus

Features
Gene ID: ENSMUSG00000025492
  
Biological name :Ifitm3
  
Synonyms : Ifitm3 / Interferon-induced transmembrane protein 3 / Q9CQW9
  
Possible biological names infered from orthology : IFITM1 / IFITM2 / interferon induced transmembrane protein 1 / interferon induced transmembrane protein 2 / P13164 / Q01628 / Q01629
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F5
Gene start: 141009586
Gene end: 141010770
  
Corresponding Affymetrix probe sets: 10569017 (MoGene1.0st)   1423754_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026565
NCBI entrez gene - 66141     See in Manteia.
MGI - MGI:1913391
RefSeq - NM_025378
RefSeq Peptide - NP_079654
swissprot - Q9CQW9
Ensembl - ENSMUSG00000025492
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IFITM3ENSGALG00000026970Gallus gallus
 IFITM1ENSG00000185885Homo sapiens
 IFITM2ENSG00000185201Homo sapiens
 IFITM3ENSG00000142089Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ifitm2 / Q99J93 / Interferon-induced transmembrane protein 2 / IFITM1* / Q01629* / IFITM3* / P13164* / Q01628* / interferon induced transmembrane protein 1* / interferon induced transmembr...ENSMUSG0000006059169
Gm45717 / IFITM2* / IFITM3* / Q01629* / IFITM1* / P13164* / Q01628* / interferon induced transmembrane protein 1* / interferon induced transmembrane protein 2* / interferon induced transmem...ENSMUSG0000011010457
Ifitm1 / Q9D103 / Interferon-induced transmembrane protein 1 / IFITM2* / Q01629* / IFITM3* / P13164* / Q01628* / interferon induced transmembrane protein 2* / interferon induced transmembr...ENSMUSG0000002549155
Ifitm7 / interferon induced transmembrane protein 7 / IFITM3* / Q01629* / IFITM1* / IFITM2* / P13164* / Q01628* / interferon induced transmembrane protein 1* / interferon induced transmemb...ENSMUSG0000006596855
Ifitm6 / IFITM2* / IFITM3* / Q01629* / IFITM1* / P13164* / Q01628* / interferon induced transmembrane protein 1* / interferon induced transmembrane protein 2* / interferon induced transmemb...ENSMUSG0000005910842
Q8BR26 / Ifitm10 / Mus musculus interferon induced transmembrane protein 10 (Ifitm10), transcript variant 3, mRNA. / A6NMD0* / interferon induced transmembrane protein 10*ENSMUSG0000004577731
Ifitm5 / O88728 / Interferon-induced transmembrane protein 5 / A6NNB3*ENSMUSG0000002548928


Protein motifs (from Interpro)
Interpro ID Name
 IPR007593  CD225/Dispanin family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006898 receptor-mediated endocytosis IMP
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0009607 response to biotic stimulus IEA
 biological_processGO:0009615 response to virus IDA
 biological_processGO:0032897 negative regulation of viral transcription ISO
 biological_processGO:0034341 response to interferon-gamma ISO
 biological_processGO:0035455 response to interferon-alpha ISO
 biological_processGO:0035456 response to interferon-beta ISO
 biological_processGO:0045071 negative regulation of viral genome replication ISO
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0046597 negative regulation of viral entry into host cell IDA
 biological_processGO:0051607 defense response to virus ISO
 biological_processGO:0060337 type I interferon signaling pathway IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0045177 apical part of cell IDA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009791 increased susceptibility to viral infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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