ENSG00000142185


Homo sapiens

Features
Gene ID: ENSG00000142185
  
Biological name :TRPM2
  
Synonyms : O94759 / transient receptor potential cation channel subfamily M member 2 / TRPM2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 21
Strand: 1
Band: q22.3
Gene start: 44350163
Gene end: 44443081
  
Corresponding Affymetrix probe sets: 205708_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000381023
Ensembl peptide - ENSP00000300482
Ensembl peptide - ENSP00000381026
Ensembl peptide - ENSP00000477514
Ensembl peptide - ENSP00000393982
Ensembl peptide - ENSP00000300481
NCBI entrez gene - 7226     See in Manteia.
OMIM - 603749
RefSeq - XM_017028457
RefSeq - NM_001320350
RefSeq - NM_001320351
RefSeq - NM_001320352
RefSeq - NM_003307
RefSeq - XM_005261171
RefSeq - XM_011529736
RefSeq - XM_017028456
RefSeq Peptide - NP_001307279
RefSeq Peptide - NP_001307281
RefSeq Peptide - NP_003298
RefSeq Peptide - NP_001307280
swissprot - A0A087WT16
swissprot - E9PGK7
swissprot - C9JZQ8
swissprot - O94759
Ensembl - ENSG00000142185
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trpm2ENSDARG00000101641Danio rerio
 TRPM2ENSGALG00000005631Gallus gallus
 Trpm2ENSMUSG00000009292Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TRPM8 / Q7Z2W7 / transient receptor potential cation channel subfamily M member 8ENSG0000014448131
TRPM5 / Q9NZQ8 / transient receptor potential cation channel subfamily M member 5ENSG0000007098528
TRPM4 / Q8TD43 / transient receptor potential cation channel subfamily M member 4ENSG0000013052928
TRPM6 / Q9BX84 / transient receptor potential cation channel subfamily M member 6ENSG0000011912126
TRPM7 / Q96QT4 / transient receptor potential cation channel subfamily M member 7ENSG0000009243926
TRPM1 / Q7Z4N2 / transient receptor potential cation channel subfamily M member 1ENSG0000013416025
TRPM3 / Q9HCF6 / transient receptor potential cation channel subfamily M member 3ENSG0000008306725


Protein motifs (from Interpro)
Interpro ID Name
 IPR000086  NUDIX hydrolase domain
 IPR005821  Ion transport domain
 IPR015797  NUDIX hydrolase-like domain superfamily
 IPR029594  Transient receptor potential cation channel subfamily M member 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001659 temperature homeostasis ISS
 biological_processGO:0002407 dendritic cell chemotaxis ISS
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006816 calcium ion transport TAS
 biological_processGO:0006828 manganese ion transport IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0014074 response to purine-containing compound IMP
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0033194 response to hydroperoxide IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035584 calcium-mediated signaling using intracellular calcium source ISS
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0044849 estrous cycle IEA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol ISS
 biological_processGO:0051489 regulation of filopodium assembly IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IDA
 biological_processGO:0070588 calcium ion transmembrane transport TAS
 biological_processGO:0071277 cellular response to calcium ion IMP
 biological_processGO:0071415 cellular response to purine-containing compound ISS
 biological_processGO:0071421 manganese ion transmembrane transport IEA
 biological_processGO:0071502 cellular response to temperature stimulus ISS
 biological_processGO:0071577 zinc ion transmembrane transport IMP
 biological_processGO:0097028 dendritic cell differentiation ISS
 biological_processGO:0097553 calcium ion transmembrane import into cytosol IMP
 biological_processGO:0098655 cation transmembrane transport IEA
 biological_processGO:0098703 calcium ion import across plasma membrane ISS
 biological_processGO:1903223 positive regulation of oxidative stress-induced neuron death IEA
 biological_processGO:2000249 regulation of actin cytoskeleton reorganization IMP
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane ISS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane ISS
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0035579 specific granule membrane TAS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0070821 tertiary granule membrane TAS
 cellular_componentGO:0101003 ficolin-1-rich granule membrane TAS
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005261 cation channel activity IEA
 molecular_functionGO:0005262 calcium channel activity TAS
 molecular_functionGO:0005272 sodium channel activity IEA
 molecular_functionGO:0005384 manganese ion transmembrane transporter activity IEA
 molecular_functionGO:0005509 calcium ion binding IMP
 molecular_functionGO:0015278 calcium-release channel activity IMP
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0047631 ADP-ribose diphosphatase activity IEA
 molecular_functionGO:0099604 ligand-gated calcium channel activity IDA


Pathways (from Reactome)
Pathway description
TRP channels
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr