ENSMUSG00000009292


Mus musculus

Features
Gene ID: ENSMUSG00000009292
  
Biological name :Trpm2
  
Synonyms : Q91YD4 / Transient receptor potential cation channel subfamily M member 2 / Trpm2
  
Possible biological names infered from orthology : O94759
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 77907722
Gene end: 77970563
  
Corresponding Affymetrix probe sets: 10370339 (MoGene1.0st)   1436225_at (Mouse Genome 430 2.0 Array)   1459482_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000101040
Ensembl peptide - ENSMUSP00000151231
Ensembl peptide - ENSMUSP00000101038
NCBI entrez gene - 28240     See in Manteia.
MGI - MGI:1351901
RefSeq - XM_006513730
RefSeq - XM_006513731
RefSeq - XM_006513732
RefSeq - NM_138301
RefSeq Peptide - NP_612174
swissprot - Q91YD4
swissprot - A0A1W2P6F5
swissprot - D3Z7Q7
Ensembl - ENSMUSG00000009292
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trpm2ENSDARG00000101641Danio rerio
 TRPM2ENSGALG00000005631Gallus gallus
 TRPM2ENSG00000142185Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trpm8 / Q8R4D5 / Transient receptor potential cation channel subfamily M member 8 / Q7Z2W7*ENSMUSG0000003625131
Trpm4 / Q7TN37 / Transient receptor potential cation channel subfamily M member 4 / Q8TD43*ENSMUSG0000003826029
Trpm5 / Q9JJH7 / Transient receptor potential cation channel subfamily M member 5 / Q9NZQ8*ENSMUSG0000000924629
Trpm7 / Q923J1 / Transient receptor potential cation channel subfamily M member 7 / Q96QT4*ENSMUSG0000002736526
Trpm3 / transient receptor potential cation channel, subfamily M, member 3 / Q9HCF6*ENSMUSG0000005238726
Trpm6 / Q8CIR4 / Transient receptor potential cation channel subfamily M member 6 / Q9BX84*ENSMUSG0000002472726
Trpm1 / Q2TV84 / Transient receptor potential cation channel subfamily M member 1 / Q7Z4N2*ENSMUSG0000003052325


Protein motifs (from Interpro)
Interpro ID Name
 IPR000086  NUDIX hydrolase domain
 IPR005821  Ion transport domain
 IPR015797  NUDIX hydrolase-like domain superfamily
 IPR029594  Transient receptor potential cation channel subfamily M member 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001659 temperature homeostasis IMP
 biological_processGO:0002407 dendritic cell chemotaxis IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006828 manganese ion transport IDA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0009408 response to heat IMP
 biological_processGO:0014074 response to purine-containing compound ISO
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0033194 response to hydroperoxide IDA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035584 calcium-mediated signaling using intracellular calcium source IMP
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0044849 estrous cycle IEA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IMP
 biological_processGO:0051489 regulation of filopodium assembly ISO
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide ISO
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0071277 cellular response to calcium ion ISO
 biological_processGO:0071415 cellular response to purine-containing compound IMP
 biological_processGO:0071421 manganese ion transmembrane transport IEA
 biological_processGO:0071502 cellular response to temperature stimulus IMP
 biological_processGO:0071577 zinc ion transmembrane transport ISS
 biological_processGO:0097028 dendritic cell differentiation IMP
 biological_processGO:0097553 calcium ion transmembrane import into cytosol ISO
 biological_processGO:0098655 cation transmembrane transport IEA
 biological_processGO:0098703 calcium ion import across plasma membrane IEA
 biological_processGO:1903223 positive regulation of oxidative stress-induced neuron death IEA
 biological_processGO:2000249 regulation of actin cytoskeleton reorganization ISS
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0005765 lysosomal membrane IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043204 perikaryon IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005261 cation channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005272 sodium channel activity IEA
 molecular_functionGO:0005384 manganese ion transmembrane transporter activity IDA
 molecular_functionGO:0005509 calcium ion binding ISS
 molecular_functionGO:0015278 calcium-release channel activity ISS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0047631 ADP-ribose diphosphatase activity IEA
 molecular_functionGO:0099604 ligand-gated calcium channel activity IMP


Pathways (from Reactome)
Pathway description
TRP channels
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Arhgef26tm1.1Kbur/Arhgef26tm1.1Kbur
Genetic Background: B6.Cg-Arhgef26tm1.1Kbur Apoetm1Unc

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dmdmdx/Dmdmdx
Genetic Background: D2.B10-Dmdmdx/J

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: Dmdmdx/Dmdmdx
Genetic Background: D2.B10-Dmdmdx/J

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bhlha15tm3(cre/ERT2)Skz/Bhlha15tm3(cre/ERT2)Skz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Etv6tm1.1(RUNX1,hsb5)Lvdw/Etv6+,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

 MP:0002446 abnormal macrophage morphology "anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Trpm2tm1Lhj/Trpm2tm1Lhj
Genetic Background: Not Specified

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

Allelic Composition: Trpm2tm1Lhj/Trpm2tm1Lhj
Genetic Background: Not Specified

 MP:0003332 liver abscess "collection of purulent exudate within the liver as a result of infection by bacteria, protozoa, or other agents " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Etv6tm1.1(RUNX1,hsb5)Lvdw/Etv6+,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Arhgef26tm1.1Kbur/Arhgef26tm1.1Kbur
Genetic Background: B6.Cg-Arhgef26tm1.1Kbur Apoetm1Unc

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Arhgef26tm1.1Kbur/Arhgef26tm1.1Kbur
Genetic Background: B6.Cg-Arhgef26tm1.1Kbur Apoetm1Unc

 MP:0004485 increased response of heart to induced stress "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Arhgef26tm1.1Kbur/Arhgef26tm1.1Kbur
Genetic Background: B6.Cg-Arhgef26tm1.1Kbur Apoetm1Unc

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dmdmdx/Dmdmdx
Genetic Background: D2.B10-Dmdmdx/J

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Arhgef26tm1.1Kbur/Arhgef26tm1.1Kbur
Genetic Background: B6.Cg-Arhgef26tm1.1Kbur Apoetm1Unc

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Etv6tm1.1(RUNX1,hsb5)Lvdw/Etv6+,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0008578 decreased circulating interferon-gamma level "reduction in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Etv6tm1.1(RUNX1,hsb5)Lvdw/Etv6+,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0008618 decreased circulating interleukin-12 level "reduction in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: Etv6tm1.1(RUNX1,hsb5)Lvdw/Etv6+,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0008648 decreased circulating interleukin-12b level "reduction in the amount in the blood of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
Show

Allelic Composition: Etv6tm1.1(RUNX1,hsb5)Lvdw/Etv6+,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0008664 decreased interleukin-12 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: Etv6tm1.1(RUNX1,hsb5)Lvdw/Etv6+,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

 MP:0008750 abnormal interferon level "deviation from the normal levels of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
Show

Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
Show

Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

 MP:0009745 abnormal behavioral response to xenobiotic "any anomaly in the behavioral response induced by a foreign compound, such as consumption preference, induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dmdmdx/Dmdmdx
Genetic Background: D2.B10-Dmdmdx/J

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Etv6tm1.1(RUNX1,hsb5)Lvdw/Etv6+,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0010579 increased heart left ventricle size "greater than average size of the left ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Arhgef26tm1.1Kbur/Arhgef26tm1.1Kbur
Genetic Background: B6.Cg-Arhgef26tm1.1Kbur Apoetm1Unc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr