ENSMUSG00000024727


Mus musculus

Features
Gene ID: ENSMUSG00000024727
  
Biological name :Trpm6
  
Synonyms : Q8CIR4 / Transient receptor potential cation channel subfamily M member 6 / Trpm6
  
Possible biological names infered from orthology : Q9BX84
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: B
Gene start: 18749983
Gene end: 18892510
  
Corresponding Affymetrix probe sets: 10461934 (MoGene1.0st)   1427642_at (Mouse Genome 430 2.0 Array)   1438877_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037443
NCBI entrez gene - 225997     See in Manteia.
MGI - MGI:2675603
RefSeq - XM_017318153
RefSeq - NM_153417
RefSeq - XM_006526951
RefSeq - XM_011247226
RefSeq - XM_017318152
RefSeq Peptide - NP_700466
swissprot - Q8CIR4
swissprot - A0A1W5LU38
Ensembl - ENSMUSG00000024727
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trpm6ENSDARG00000103454Danio rerio
 TRPM6ENSGALG00000015154Gallus gallus
 TRPM6ENSG00000119121Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trpm7 / Q923J1 / Transient receptor potential cation channel subfamily M member 7 / Q96QT4*ENSMUSG0000002736549
Trpm3 / transient receptor potential cation channel, subfamily M, member 3 / Q9HCF6*ENSMUSG0000005238736
Trpm1 / Q2TV84 / Transient receptor potential cation channel subfamily M member 1 / Q7Z4N2*ENSMUSG0000003052334
Trpm2 / Q91YD4 / Transient receptor potential cation channel subfamily M member 2 / O94759*ENSMUSG0000000929219
Trpm4 / Q7TN37 / Transient receptor potential cation channel subfamily M member 4 / Q8TD43*ENSMUSG0000003826016
Trpm5 / Q9JJH7 / Transient receptor potential cation channel subfamily M member 5 / Q9NZQ8*ENSMUSG0000000924615
Trpm8 / Q8R4D5 / Transient receptor potential cation channel subfamily M member 8 / Q7Z2W7*ENSMUSG0000003625114


Protein motifs (from Interpro)
Interpro ID Name
 IPR004166  MHCK/EF2 kinase
 IPR005821  Ion transport domain
 IPR011009  Protein kinase-like domain superfamily
 IPR029597  Transient receptor potential cation channel subfamily M member 6
 IPR032415  TRPM, tetramerisation domain
 IPR037162  TRPM, tetramerisation domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0009636 response to toxic substance ISO
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030001 metal ion transport IDA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0051262 protein tetramerization IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0098655 cation transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0031526 brush border membrane IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005261 cation channel activity IDA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
TRP channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
Show

Allelic Composition: Ets2tm1Rgo/Ets2tm5.1Rgo,Tg(MMTV-PyVT)634Mul/0,Tg(S100a4-cre)1Gle/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
Show

Allelic Composition: Ets2tm1Rgo/Ets2tm5.1Rgo,Tg(MMTV-PyVT)634Mul/0,Tg(S100a4-cre)1Gle/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Ets2tm1Rgo/Ets2tm5.1Rgo,Tg(MMTV-PyVT)634Mul/0,Tg(S100a4-cre)1Gle/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0001919 abnormal reproductive system physiology "anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ets2tm1Rgo/Ets2tm5.1Rgo,Tg(MMTV-PyVT)634Mul/0,Tg(S100a4-cre)1Gle/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ets2tm1Rgo/Ets2tm5.1Rgo,Tg(MMTV-PyVT)634Mul/0,Tg(S100a4-cre)1Gle/0
Genetic Background: involves: 129S2/SvPas * FVB/N

Allelic Composition: Trpm6tm1.1Rws/Trpm6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
Show

Allelic Composition: Ets2tm1Rgo/Ets2tm5.1Rgo,Tg(MMTV-PyVT)634Mul/0,Tg(S100a4-cre)1Gle/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0003743 abnormal facial morphology "anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Ets2tm1Rgo/Ets2tm5.1Rgo,Tg(MMTV-PyVT)634Mul/0,Tg(S100a4-cre)1Gle/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0003935 abnormal craniofacial development "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ets2tm1Rgo/Ets2tm5.1Rgo,Tg(MMTV-PyVT)634Mul/0,Tg(S100a4-cre)1Gle/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ets2tm1Rgo/Ets2tm5.1Rgo,Tg(MMTV-PyVT)634Mul/0,Tg(S100a4-cre)1Gle/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0005297 spina bifida occulta "common congenital midline defect of fusion of the vertebral arch without protrusion of the spinal cord or meninges" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ets2tm1Rgo/Ets2tm5.1Rgo,Tg(MMTV-PyVT)634Mul/0,Tg(S100a4-cre)1Gle/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ets2tm1Rgo/Ets2tm5.1Rgo,Tg(MMTV-PyVT)634Mul/0,Tg(S100a4-cre)1Gle/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0010093 decreased circulating magnesium level "a reduction in the blood concentration of magnesium" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Trpm6tm1.1Rws/Trpm6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ets2tm1Rgo/Ets2tm5.1Rgo,Tg(MMTV-PyVT)634Mul/0,Tg(S100a4-cre)1Gle/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Ets2tm1Rgo/Ets2tm5.1Rgo,Tg(MMTV-PyVT)634Mul/0,Tg(S100a4-cre)1Gle/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Ets2tm1Rgo/Ets2tm5.1Rgo,Tg(MMTV-PyVT)634Mul/0,Tg(S100a4-cre)1Gle/0
Genetic Background: involves: 129S2/SvPas * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr