ENSMUSG00000027365


Mus musculus

Features
Gene ID: ENSMUSG00000027365
  
Biological name :Trpm7
  
Synonyms : Q923J1 / Transient receptor potential cation channel subfamily M member 7 / Trpm7
  
Possible biological names infered from orthology : Q96QT4
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: F1
Gene start: 126791565
Gene end: 126876230
  
Corresponding Affymetrix probe sets: 10487277 (MoGene1.0st)   1416799_at (Mouse Genome 430 2.0 Array)   1416800_at (Mouse Genome 430 2.0 Array)   1416801_at (Mouse Genome 430 2.0 Array)   1431355_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119232
Ensembl peptide - ENSMUSP00000028843
Ensembl peptide - ENSMUSP00000099513
NCBI entrez gene - 58800     See in Manteia.
MGI - MGI:1929996
RefSeq - NM_021450
RefSeq - XM_017319154
RefSeq - NM_001164325
RefSeq Peptide - NP_001157797
RefSeq Peptide - NP_067425
swissprot - A2AI57
swissprot - Q923J1
swissprot - F6QKC0
Ensembl - ENSMUSG00000027365
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trpm7ENSDARG00000036232Danio rerio
 TRPM7ENSGALG00000023451Gallus gallus
 TRPM7ENSG00000092439Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trpm6 / Q8CIR4 / Transient receptor potential cation channel subfamily M member 6 / Q9BX84*ENSMUSG0000002472753
Trpm3 / transient receptor potential cation channel, subfamily M, member 3 / Q9HCF6*ENSMUSG0000005238744
Trpm1 / Q2TV84 / Transient receptor potential cation channel subfamily M member 1 / Q7Z4N2*ENSMUSG0000003052340
Trpm2 / Q91YD4 / Transient receptor potential cation channel subfamily M member 2 / O94759*ENSMUSG0000000929221
Trpm4 / Q7TN37 / Transient receptor potential cation channel subfamily M member 4 / Q8TD43*ENSMUSG0000003826018
Trpm5 / Q9JJH7 / Transient receptor potential cation channel subfamily M member 5 / Q9NZQ8*ENSMUSG0000000924617
Trpm8 / Q8R4D5 / Transient receptor potential cation channel subfamily M member 8 / Q7Z2W7*ENSMUSG0000003625116


Protein motifs (from Interpro)
Interpro ID Name
 IPR004166  MHCK/EF2 kinase
 IPR005821  Ion transport domain
 IPR011009  Protein kinase-like domain superfamily
 IPR029601  Transient receptor potential cation channel subfamily M member 7
 IPR032415  TRPM, tetramerisation domain
 IPR037162  TRPM, tetramerisation domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IEA
 biological_processGO:0006816 calcium ion transport IDA
 biological_processGO:0010961 cellular magnesium ion homeostasis IEA
 biological_processGO:0012501 programmed cell death IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016340 calcium-dependent cell-matrix adhesion IDA
 biological_processGO:0031032 actomyosin structure organization IDA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0051262 protein tetramerization IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070266 necroptotic process IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0001726 ruffle IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003779 actin binding IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017022 myosin binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
TRP channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
Show

Allelic Composition: Adgre5tm1.1Joha/Adgre5tm1.1Joha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Adgre5tm1.1Joha/Adgre5tm1.1Joha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Msx2-rtTA)885Lma/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Msx2-rtTA)885Lma/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0001664 abnormal digestion "altered ability of the mechanical, chemical, and enzymatic processes of the body to convert ingested food into material suitable for assimiliation for synthesis of tissues or liberation of energy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Msx2-rtTA)885Lma/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Msx2-rtTA)885Lma/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Msx2-rtTA)885Lma/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Msx2-rtTA)885Lma/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adgre5tm1.1Joha/Adgre5tm1.1Joha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0002375 abnormal thymus medulla morphology "anomalous structure or development of the inner area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Adgre5tm1.1Joha/Adgre5tm1.1Joha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Adgre5tm1.1Joha/Adgre5tm1.1Joha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0003484 abnormal channel response "anomalies in the electrophysiological recordings from ion channels" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Msx2-rtTA)885Lma/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Adgre5tm1.1Joha/Adgre5tm1.1Joha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0005617 increased susceptibility to type IV hypersensitivity reaction "greater likelihood of developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Msx2-rtTA)885Lma/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Msx2-rtTA)885Lma/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0008827 abnormal thymus cell ratio "deviation from the standard ratios of thymocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Adgre5tm1.1Joha/Adgre5tm1.1Joha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0009543 abnormal thymus corticomedullary boundary morphology "any structural anomaly of the dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17067941]
Show

Allelic Composition: Adgre5tm1.1Joha/Adgre5tm1.1Joha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Msx2-rtTA)885Lma/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0010093 decreased circulating magnesium level "a reduction in the blood concentration of magnesium" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Msx2-rtTA)885Lma/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Msx2-rtTA)885Lma/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Kmt2atm1Saam/Kmt2a+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Trpm7tm1Clph/Trpm7tm1.1Clph,Tg(Gata1-cre)1Sho/0
Genetic Background: involves: 129S4/SvJae * CD-1

Allelic Composition: Trpm7tm1Clph/Trpm7tm1.1Clph,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Trpm7tm1Clph/Trpm7tm1.1Clph,Tg(Gata1-cre)1Sho/0
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0011436 decreased urine magnesium level "lower than normal amount of magnesium in the urine" [MGI:anna]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Msx2-rtTA)885Lma/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0011979 abnormal magnesium ion homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of magnesium ions within the body or between a cell and its external environment" [MPD:Molly]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Msx2-rtTA)885Lma/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0012367 decreased erythrocyte magnesium level "decrease in the amount in red blood cells of magnesium" [MPD:Molly]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Msx2-rtTA)885Lma/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr