ENSG00000143753


Homo sapiens

Features
Gene ID: ENSG00000143753
  
Biological name :DEGS1
  
Synonyms : DEGS1 / delta 4-desaturase, sphingolipid 1 / O15121
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q42.11
Gene start: 224175756
Gene end: 224193441
  
Corresponding Affymetrix probe sets: 207431_s_at (Human Genome U133 Plus 2.0 Array)   209250_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000375749
Ensembl peptide - ENSP00000400545
Ensembl peptide - ENSP00000316476
NCBI entrez gene - 8560     See in Manteia.
OMIM - 615843
RefSeq - XM_017002648
RefSeq - NM_001321541
RefSeq - NM_001321542
RefSeq - NM_003676
RefSeq Peptide - NP_001308470
RefSeq Peptide - NP_001308471
RefSeq Peptide - NP_003667
swissprot - A0A024R3P1
swissprot - E7EMA0
swissprot - O15121
Ensembl - ENSG00000143753
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 degs1ENSDARG00000007347Danio rerio
 DEGS1ENSGALG00000009330Gallus gallus
 9130409I23RikENSMUSG00000038768Mus musculus
 Degs1ENSMUSG00000038633Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DEGS2 / Q6QHC5 / delta 4-desaturase, sphingolipid 2ENSG0000016835063


Protein motifs (from Interpro)
Interpro ID Name
 IPR005804  Fatty acid desaturase domain
 IPR011388  Sphingolipid delta4-desaturase
 IPR013866  Sphingolipid delta4-desaturase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0006636 unsaturated fatty acid biosynthetic process TAS
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0030148 sphingolipid biosynthetic process TAS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0046513 ceramide biosynthetic process IBA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum TAS
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0035579 specific granule membrane TAS
 molecular_functionGO:0009055 electron transfer activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0042284 sphingolipid delta-4 desaturase activity TAS


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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