ENSMUSG00000038633


Mus musculus

Features
Gene ID: ENSMUSG00000038633
  
Biological name :Degs1
  
Synonyms : Degs1 / O09005 / Sphingolipid delta(4)-desaturase DES1
  
Possible biological names infered from orthology : delta 4-desaturase, sphingolipid 1 / O15121
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H5
Gene start: 182275772
Gene end: 182282804
  
Corresponding Affymetrix probe sets: 10360789 (MoGene1.0st)   1423345_at (Mouse Genome 430 2.0 Array)   1423346_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048519
Ensembl peptide - ENSMUSP00000119473
NCBI entrez gene - 13244     See in Manteia.
MGI - MGI:1097711
RefSeq - NM_007853
RefSeq - XM_017314467
RefSeq Peptide - NP_031879
swissprot - F6S3U4
swissprot - O09005
Ensembl - ENSMUSG00000038633
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 degs1ENSDARG00000007347Danio rerio
 DEGS1ENSGALG00000009330Gallus gallus
 DEGS1ENSG00000143753Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
9130409I23Rik / RIKEN cDNA 9130409I23 gene / DEGS1* / O15121* / delta 4-desaturase, sphingolipid 1*ENSMUSG0000003876872
Degs2 / Q8R2F2 / Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 / Q6QHC5* / delta 4-desaturase, sphingolipid 2*ENSMUSG0000002126362


Protein motifs (from Interpro)
Interpro ID Name
 IPR005804  Fatty acid desaturase domain
 IPR011388  Sphingolipid delta4-desaturase
 IPR013866  Sphingolipid delta4-desaturase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0030148 sphingolipid biosynthetic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0046513 ceramide biosynthetic process IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0042284 sphingolipid delta-4 desaturase activity IMP


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+,Meox1tm1(cre)Jpa/Meox1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+,Meox1tm1(cre)Jpa/Meox1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+,Meox1tm1(cre)Jpa/Meox1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+,Meox1tm1(cre)Jpa/Meox1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+,Meox1tm1(cre)Jpa/Meox1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+,Meox1tm1(cre)Jpa/Meox1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+,Meox1tm1(cre)Jpa/Meox1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+,Meox1tm1(cre)Jpa/Meox1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+,Meox1tm1(cre)Jpa/Meox1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0002396 abnormal hematopoietic system morphology/development "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+,Meox1tm1(cre)Jpa/Meox1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+,Meox1tm1(cre)Jpa/Meox1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+,Meox1tm1(cre)Jpa/Meox1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+,Meox1tm1(cre)Jpa/Meox1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0003325 decreased liver function "reduced normal function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+,Meox1tm1(cre)Jpa/Meox1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+,Meox1tm1(cre)Jpa/Meox1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+,Meox1tm1(cre)Jpa/Meox1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+,Meox1tm1(cre)Jpa/Meox1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+,Meox1tm1(cre)Jpa/Meox1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0012232 abnormal ceramide level 
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+,Meox1tm1(cre)Jpa/Meox1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Degs1Gt(OST368559)Lex/Degs1+
Genetic Background: involves: 129S5/SvEvBrd

 MP:0030021 increased muscle cell glucose uptake "increased ability of muscle cells to take in glucose" [MGI:anna]
Show

Allelic Composition: Degs1Gt(OST368559)Lex/Degs1+
Genetic Background: involves: 129S5/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr