ENSG00000145545


Homo sapiens

Features
Gene ID: ENSG00000145545
  
Biological name :SRD5A1
  
Synonyms : P18405 / SRD5A1 / steroid 5 alpha-reductase 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: p15.31
Gene start: 6633343
Gene end: 6674386
  
Corresponding Affymetrix probe sets: 204675_at (Human Genome U133 Plus 2.0 Array)   210959_s_at (Human Genome U133 Plus 2.0 Array)   211056_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000421342
Ensembl peptide - ENSP00000425330
Ensembl peptide - ENSP00000274192
NCBI entrez gene - 6715     See in Manteia.
OMIM - 184753
RefSeq - NM_001047
RefSeq - NM_001324322
RefSeq - NM_001324323
RefSeq Peptide - NP_001311252
RefSeq Peptide - NP_001038
RefSeq Peptide - NP_001311251
swissprot - P18405
swissprot - D6RG03
swissprot - D6RDL6
Ensembl - ENSG00000145545
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 srd5a1ENSDARG00000020509Danio rerio
 SRD5A1ENSGALG00000013063Gallus gallus
 Srd5a1ENSMUSG00000021594Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P31213 / SRD5A2 / steroid 5 alpha-reductase 2ENSG0000027789347


Protein motifs (from Interpro)
Interpro ID Name
 IPR001104  3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal
 IPR016636  3-oxo-5-alpha-steroid 4-dehydrogenase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001655 urogenital system development IEA
 biological_processGO:0001889 liver development IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0006702 androgen biosynthetic process IEA
 biological_processGO:0007530 sex determination NAS
 biological_processGO:0007548 sex differentiation IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008209 androgen metabolic process IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0009267 cellular response to starvation IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0014850 response to muscle activity IEA
 biological_processGO:0016101 diterpenoid metabolic process IEA
 biological_processGO:0021510 spinal cord development IEA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0021794 thalamus development IEA
 biological_processGO:0021854 hypothalamus development IEA
 biological_processGO:0021983 pituitary gland development IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030539 male genitalia development IEA
 biological_processGO:0030540 female genitalia development IEA
 biological_processGO:0032354 response to follicle-stimulating hormone IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0042428 serotonin metabolic process IEA
 biological_processGO:0042448 progesterone metabolic process IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042747 circadian sleep/wake cycle, REM sleep IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060348 bone development IEA
 biological_processGO:0060416 response to growth hormone IEA
 biological_processGO:0060992 response to fungicide IEA
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0071392 cellular response to estradiol stimulus IEA
 biological_processGO:0071394 cellular response to testosterone stimulus IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 biological_processGO:0071872 cellular response to epinephrine stimulus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070852 cell body fiber IEA
 molecular_functionGO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity TAS
 molecular_functionGO:0009055 electron transfer activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016627 oxidoreductase activity, acting on the CH-CH group of donors IEA
 molecular_functionGO:0033218 amide binding IEA
 molecular_functionGO:0047751 cholestenone 5-alpha-reductase activity IEA
 molecular_functionGO:0070402 NADPH binding IEA


Pathways (from Reactome)
Pathway description
Androgen biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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