ENSMUSG00000021594


Mus musculus

Features
Gene ID: ENSMUSG00000021594
  
Biological name :Srd5a1
  
Synonyms : Srd5a1 / steroid 5 alpha-reductase 1
  
Possible biological names infered from orthology : P18405
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: C1
Gene start: 69573449
Gene end: 69611442
  
Corresponding Affymetrix probe sets: 10410452 (MoGene1.0st)   1431101_a_at (Mouse Genome 430 2.0 Array)   1438699_at (Mouse Genome 430 2.0 Array)   1454649_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000089097
NCBI entrez gene - 78925     See in Manteia.
MGI - MGI:98400
RefSeq - NM_175283
RefSeq Peptide - NP_780492
swissprot - A0A0R4J136
Ensembl - ENSMUSG00000021594
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 srd5a1ENSDARG00000020509Danio rerio
 SRD5A1ENSGALG00000013063Gallus gallus
 P18405ENSG00000145545Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q99N99 / Srd5a2 / 3-oxo-5-alpha-steroid 4-dehydrogenase 2 / P31213* / steroid 5 alpha-reductase 2*ENSMUSG0000003854144


Protein motifs (from Interpro)
Interpro ID Name
 IPR001104  3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal
 IPR016636  3-oxo-5-alpha-steroid 4-dehydrogenase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001655 urogenital system development IEA
 biological_processGO:0001889 liver development IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0006702 androgen biosynthetic process IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008209 androgen metabolic process IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0009267 cellular response to starvation IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0014850 response to muscle activity IEA
 biological_processGO:0016101 diterpenoid metabolic process IEA
 biological_processGO:0021510 spinal cord development IEA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0021794 thalamus development IEA
 biological_processGO:0021854 hypothalamus development IEA
 biological_processGO:0021983 pituitary gland development IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0030539 male genitalia development IEA
 biological_processGO:0030540 female genitalia development IEA
 biological_processGO:0032354 response to follicle-stimulating hormone IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0042428 serotonin metabolic process IEA
 biological_processGO:0042448 progesterone metabolic process IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042747 circadian sleep/wake cycle, REM sleep IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060348 bone development IEA
 biological_processGO:0060416 response to growth hormone IEA
 biological_processGO:0060992 response to fungicide IEA
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0071392 cellular response to estradiol stimulus IEA
 biological_processGO:0071394 cellular response to testosterone stimulus IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 biological_processGO:0071872 cellular response to epinephrine stimulus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070852 cell body fiber IEA
 molecular_functionGO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity IEA
 molecular_functionGO:0016627 oxidoreductase activity, acting on the CH-CH group of donors IEA
 molecular_functionGO:0033218 amide binding IEA
 molecular_functionGO:0070402 NADPH binding IEA


Pathways (from Reactome)
Pathway description
Androgen biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000664 small coagulating gland "reduced size of the coagulating gland" [J:64981]
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Allelic Composition: Srd5a1tm1Mahe/Srd5a1tm1Mahe,Srd5a2tm1Mahe/Srd5a2tm1Mahe
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

 MP:0001157 small seminal gland "reduced size, compared to the norm, of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Srd5a1tm1Mahe/Srd5a1tm1Mahe,Srd5a2tm1Mahe/Srd5a2tm1Mahe
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Srd5a1tm1Mahe/Srd5a1tm1Mahe,Srd5a2tm1Mahe/Srd5a2tm1Mahe
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

 MP:0002774 small prostate "reduced size of the gland in males that secretes part of the seminiferous fluid" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Srd5a1tm1Mahe/Srd5a1tm1Mahe,Srd5a2tm1Mahe/Srd5a2tm1Mahe
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

 MP:0002907 abnormal parturition "defect in the process of labor and delivery in female animals " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Srd5a1tm1Mahe/Srd5a1tm1Mahe,Srd5a2tm1Mahe/Srd5a2tm1Mahe
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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