ENSMUSG00000038541


Mus musculus

Features
Gene ID: ENSMUSG00000038541
  
Biological name :Srd5a2
  
Synonyms : 3-oxo-5-alpha-steroid 4-dehydrogenase 2 / Q99N99 / Srd5a2
  
Possible biological names infered from orthology : P31213 / steroid 5 alpha-reductase 2
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: E2
Gene start: 74017706
Gene end: 74047916
  
Corresponding Affymetrix probe sets: 10452854 (MoGene1.0st)   1422960_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048862
NCBI entrez gene - 94224     See in Manteia.
MGI - MGI:2150380
RefSeq - NM_053188
RefSeq Peptide - NP_444418
swissprot - Q99N99
Ensembl - ENSMUSG00000038541
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 srd5a2aENSDARG00000043587Danio rerio
 srd5a2bENSDARG00000039067Danio rerio
 SRD5A2ENSGALG00000010625Gallus gallus
 P31213ENSG00000277893Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Srd5a1 / steroid 5 alpha-reductase 1 / P18405*ENSMUSG0000002159444


Protein motifs (from Interpro)
Interpro ID Name
 IPR001104  3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal
 IPR016636  3-oxo-5-alpha-steroid 4-dehydrogenase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0006702 androgen biosynthetic process IEA
 biological_processGO:0006706 steroid catabolic process IEA
 biological_processGO:0007548 sex differentiation IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008209 androgen metabolic process IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0018879 biphenyl metabolic process IEA
 biological_processGO:0018894 dibenzo-p-dioxin metabolic process IEA
 biological_processGO:0018963 phthalate metabolic process IEA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0021854 hypothalamus development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030539 male genitalia development IEA
 biological_processGO:0030540 female genitalia development IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0032354 response to follicle-stimulating hormone IEA
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0042448 progesterone metabolic process IBA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0048545 response to steroid hormone IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060348 bone development IEA
 biological_processGO:0061370 testosterone biosynthetic process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0070852 cell body fiber IEA
 molecular_functionGO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity IMP
 molecular_functionGO:0009917 sterol 5-alpha reductase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016627 oxidoreductase activity, acting on the CH-CH group of donors IEA
 molecular_functionGO:0030283 testosterone dehydrogenase [NAD(P)] activity IEA
 molecular_functionGO:0033218 amide binding IEA
 molecular_functionGO:0047751 cholestenone 5-alpha-reductase activity IEA


Pathways (from Reactome)
Pathway description
Androgen biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000664 small coagulating gland "reduced size of the coagulating gland" [J:64981]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Srd5a1tm1Mahe/Srd5a1tm1Mahe,Srd5a2tm1Mahe/Srd5a2tm1Mahe
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

 MP:0001157 small seminal gland "reduced size, compared to the norm, of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Srd5a1tm1Mahe/Srd5a1tm1Mahe,Srd5a2tm1Mahe/Srd5a2tm1Mahe
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Srd5a1tm1Mahe/Srd5a1tm1Mahe,Srd5a2tm1Mahe/Srd5a2tm1Mahe
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

 MP:0002774 small prostate "reduced size of the gland in males that secretes part of the seminiferous fluid" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Srd5a1tm1Mahe/Srd5a1tm1Mahe,Srd5a2tm1Mahe/Srd5a2tm1Mahe
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

 MP:0002907 abnormal parturition "defect in the process of labor and delivery in female animals " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Srd5a1tm1Mahe/Srd5a1tm1Mahe,Srd5a2tm1Mahe/Srd5a2tm1Mahe
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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