ENSG00000152942


Homo sapiens

Features
Gene ID: ENSG00000152942
  
Biological name :RAD17
  
Synonyms : O75943 / RAD17 / RAD17 checkpoint clamp loader component
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q13.2
Gene start: 69369293
Gene end: 69414801
  
Corresponding Affymetrix probe sets: 207405_s_at (Human Genome U133 Plus 2.0 Array)   210826_x_at (Human Genome U133 Plus 2.0 Array)   211228_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000426191
Ensembl peptide - ENSP00000425005
Ensembl peptide - ENSP00000427673
Ensembl peptide - ENSP00000482775
Ensembl peptide - ENSP00000427743
Ensembl peptide - ENSP00000282891
Ensembl peptide - ENSP00000303134
Ensembl peptide - ENSP00000311227
Ensembl peptide - ENSP00000346271
Ensembl peptide - ENSP00000346938
Ensembl peptide - ENSP00000350725
Ensembl peptide - ENSP00000355226
Ensembl peptide - ENSP00000370151
Ensembl peptide - ENSP00000423060
Ensembl peptide - ENSP00000424289
Ensembl peptide - ENSP00000424696
NCBI entrez gene - 5884     See in Manteia.
OMIM - 603139
RefSeq - NM_133340
RefSeq - NM_001278622
RefSeq - NM_002873
RefSeq - NM_133338
RefSeq - NM_133339
RefSeq - NM_133341
RefSeq - NM_133342
RefSeq - NM_133343
RefSeq - NM_133344
RefSeq - XM_017009679
RefSeq - XM_017009680
RefSeq - XM_017009681
RefSeq Peptide - NP_579922
RefSeq Peptide - NP_579916
RefSeq Peptide - NP_579917
RefSeq Peptide - NP_579918
RefSeq Peptide - NP_579919
RefSeq Peptide - NP_579920
RefSeq Peptide - NP_579921
RefSeq Peptide - NP_001265551
RefSeq Peptide - NP_002864
swissprot - O75943
swissprot - H0Y9T7
swissprot - D6RA84
swissprot - D6RHU1
swissprot - D6RAW6
swissprot - H0Y9J8
Ensembl - ENSG00000152942
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rad17ENSDARG00000018918Danio rerio
 RAD17ENSGALG00000015571Gallus gallus
 Rad17ENSMUSG00000021635Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004582  Checkpoint protein Rad17/Rad24
 IPR018324  Checkpoint protein Rad17/Rad24, fungi/metazoa
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000076 DNA replication checkpoint TAS
 biological_processGO:0000077 DNA damage checkpoint IMP
 biological_processGO:0006260 DNA replication TAS
 biological_processGO:0006281 DNA repair IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007093 mitotic cell cycle checkpoint IMP
 biological_processGO:0008156 negative regulation of DNA replication IMP
 biological_processGO:0033314 mitotic DNA replication checkpoint IBA
 biological_processGO:0042325 regulation of phosphorylation IMP
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 cellular_componentGO:0000781 chromosome, telomeric region IDA
 cellular_componentGO:0000790 nuclear chromatin IBA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0031389 Rad17 RFC-like complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003682 chromatin binding IBA
 molecular_functionGO:0003689 DNA clamp loader activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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