ENSMUSG00000021635


Mus musculus

Features
Gene ID: ENSMUSG00000021635
  
Biological name :Rad17
  
Synonyms : Q6NXW6 / Rad17 / RAD17 checkpoint clamp loader component
  
Possible biological names infered from orthology : O75943
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: D1
Gene start: 100617164
Gene end: 100651051
  
Corresponding Affymetrix probe sets: 10411690 (MoGene1.0st)   1448762_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022136
Ensembl peptide - ENSMUSP00000136292
Ensembl peptide - ENSMUSP00000152977
NCBI entrez gene - 19356     See in Manteia.
MGI - MGI:1333807
RefSeq - NM_001283011
RefSeq - NM_001044371
RefSeq - NM_011233
RefSeq Peptide - NP_001037836
RefSeq Peptide - NP_001269940
RefSeq Peptide - NP_035363
swissprot - Q6NXW6
swissprot - Q3UYY2
swissprot - A0A286YCW1
Ensembl - ENSMUSG00000021635
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rad17ENSDARG00000018918Danio rerio
 RAD17ENSGALG00000015571Gallus gallus
 RAD17ENSG00000152942Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR004582  Checkpoint protein Rad17/Rad24
 IPR018324  Checkpoint protein Rad17/Rad24, fungi/metazoa
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint IBA
 biological_processGO:0006281 DNA repair IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007093 mitotic cell cycle checkpoint ISO
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008156 negative regulation of DNA replication ISO
 biological_processGO:0033314 mitotic DNA replication checkpoint IBA
 biological_processGO:0042325 regulation of phosphorylation ISO
 cellular_componentGO:0000781 chromosome, telomeric region ISO
 cellular_componentGO:0000790 nuclear chromatin IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031389 Rad17 RFC-like complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003682 chromatin binding IBA
 molecular_functionGO:0003689 DNA clamp loader activity IBA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rs1tm1Sie/Rs1tm1Sie
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Rs1tm1Sie/Rs1tm1Sie
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
Show

Allelic Composition: Rs1tm1Sie/Rs1tm1Sie
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rs1tm1Sie/Rs1tm1Sie
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rs1tm1Sie/Rs1tm1Sie
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002884 abnormal branchial arches "malformation or anomaly in the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rs1tm1Sie/Rs1tm1Sie
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Rs1tm1Sie/Rs1tm1Sie
Genetic Background: involves: 129S/SvEv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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