ENSG00000156026


Homo sapiens

Features
Gene ID: ENSG00000156026
  
Biological name :MCU
  
Synonyms : MCU / mitochondrial calcium uniporter / Q8NE86
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q22.1
Gene start: 72692131
Gene end: 72887694
  
Corresponding Affymetrix probe sets: 225320_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000475141
Ensembl peptide - ENSP00000349680
Ensembl peptide - ENSP00000362144
Ensembl peptide - ENSP00000474265
Ensembl peptide - ENSP00000474820
Ensembl peptide - ENSP00000440913
Ensembl peptide - ENSP00000473857
Ensembl peptide - ENSP00000473892
NCBI entrez gene - 90550     See in Manteia.
OMIM - 614197
RefSeq - XM_017016882
RefSeq - NM_001270679
RefSeq - NM_001270680
RefSeq - NM_138357
RefSeq Peptide - NP_001257609
RefSeq Peptide - NP_612366
RefSeq Peptide - NP_001257608
swissprot - S4R319
swissprot - S4R332
swissprot - S4R3F5
swissprot - S4R3W8
swissprot - S4R468
swissprot - Q8NE86
Ensembl - ENSG00000156026
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mcuENSDARG00000101175Danio rerio
 MCUENSGALG00000004355Gallus gallus
 McuENSMUSG00000009647Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MCUB / Q9NWR8 / mitochondrial calcium uniporter dominant negative beta subunitENSG0000000505940


Protein motifs (from Interpro)
Interpro ID Name
 IPR006769  Coiled-coil domain containing protein 109, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006851 mitochondrial calcium ion transmembrane transport IMP
 biological_processGO:0019722 calcium-mediated signaling IDA
 biological_processGO:0032024 positive regulation of insulin secretion IMP
 biological_processGO:0036444 calcium import into the mitochondrion IDA
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0051560 mitochondrial calcium ion homeostasis IEA
 biological_processGO:0051561 positive regulation of mitochondrial calcium ion concentration IMP
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031305 integral component of mitochondrial inner membrane IDA
 cellular_componentGO:0034704 calcium channel complex ISS
 cellular_componentGO:1990246 uniplex complex IDA
 molecular_functionGO:0005262 calcium channel activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015292 uniporter activity IMP
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Mitochondrial calcium ion transport
Processing of SMDT1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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