ENSMUSG00000009647


Mus musculus

Features
Gene ID: ENSMUSG00000009647
  
Biological name :Mcu
  
Synonyms : Calcium uniporter protein, mitochondrial / Mcu / Q3UMR5
  
Possible biological names infered from orthology : mitochondrial calcium uniporter / Q8NE86
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: B4
Gene start: 59446984
Gene end: 59616692
  
Corresponding Affymetrix probe sets: 10369276 (MoGene1.0st)   1442031_at (Mouse Genome 430 2.0 Array)   1453166_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124087
Ensembl peptide - ENSMUSP00000009791
Ensembl peptide - ENSMUSP00000020312
NCBI entrez gene - 215999     See in Manteia.
MGI - MGI:3026965
RefSeq - NM_001033259
RefSeq - XM_006513468
RefSeq Peptide - NP_001028431
swissprot - E0CYL3
swissprot - Q3UMR5
Ensembl - ENSMUSG00000009647
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mcuENSDARG00000101175Danio rerio
 MCUENSGALG00000004355Gallus gallus
 MCUENSG00000156026Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mcub / Q810S1 / Calcium uniporter regulatory subunit MCUb, mitochondrial / Q9NWR8* / mitochondrial calcium uniporter dominant negative beta subunit*ENSMUSG0000002799439


Protein motifs (from Interpro)
Interpro ID Name
 IPR006769  Coiled-coil domain containing protein 109, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006851 mitochondrial calcium ion transmembrane transport IMP
 biological_processGO:0019722 calcium-mediated signaling IEA
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0036444 calcium import into the mitochondrion IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0051560 mitochondrial calcium ion homeostasis IEA
 biological_processGO:0051561 positive regulation of mitochondrial calcium ion concentration IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031305 integral component of mitochondrial inner membrane IEA
 cellular_componentGO:0034704 calcium channel complex IEA
 cellular_componentGO:1990246 uniplex complex IEA
 molecular_functionGO:0005262 calcium channel activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015292 uniporter activity IEA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
Mitochondrial calcium ion transport
Processing of SMDT1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Mcutm1.1Jmol/Mcutm1.1Jmol,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Tnfrsf1atm1Mak/Tnfrsf1a+
Genetic Background: involves: 129S2/SvPas

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Tnfrsf1atm1Mak/Tnfrsf1a+
Genetic Background: involves: 129S2/SvPas

 MP:0003038 decreased infarction size "decreased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Mcutm1.1Jmol/Mcutm1.1Jmol,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0003061 decreased aerobic running capacity "reduced ability to run at defined speeds and/or distances compared to controls" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Mcutm1.1Jmol/Mcutm1.1Jmol,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0003223 decreased cardiomyocyte apoptosis "decrease in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Mcutm1.1Jmol/Mcutm1.1Jmol,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mcutm1.1Jmol/Mcutm1.1Jmol,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tnfrsf1atm1Mak/Tnfrsf1a+
Genetic Background: involves: 129S2/SvPas

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Mcutm1.1Jmol/Mcutm1.1Jmol,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnfrsf1atm1Mak/Tnfrsf1a+
Genetic Background: involves: 129S2/SvPas

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Mcur1tm1c(KOMP)Wtsi/Mcur1tm1c(KOMP)Wtsi,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * FVB/N

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Tnfrsf1atm1Mak/Tnfrsf1a+
Genetic Background: involves: 129S2/SvPas

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Marveld2tm1b(EUCOMM)Wtsi/Marveld2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Marveld2tm1b(EUCOMM)Wtsi/H

 MP:0011134 decreased lung endothelial cell migration "reduced or slower movement of endothelial cells or their precursors to the appropriate location in the pulmonary vasculature" [MGI:csmith]
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Allelic Composition: Mcur1tm1c(KOMP)Wtsi/Mcur1tm1c(KOMP)Wtsi,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * FVB/N

 MP:0011140 decreased lung endothelial cell proliferation "reduced ability of an endothelial cell in the pulmonary vasculature to undergo expansion by cell division" [MGI:csmith]
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Allelic Composition: Mcur1tm1c(KOMP)Wtsi/Mcur1tm1c(KOMP)Wtsi,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * FVB/N

 MP:0011952 decreased cardiac stroke volume "reduction in the volume of blood pushed into the aorta with each beat of the heart" [MGI:csmith]
Show

Allelic Composition: Marveld2tm1b(EUCOMM)Wtsi/Marveld2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Marveld2tm1b(EUCOMM)Wtsi/H

 MP:0012106 impaired exercise endurance "impaired performance during controlled physical activity" [MGI:smb]
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Allelic Composition: Tnfrsf1atm1Mak/Tnfrsf1a+
Genetic Background: involves: 129S2/SvPas

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
Show

Allelic Composition: Marveld2tm1b(EUCOMM)Wtsi/Marveld2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Marveld2tm1b(EUCOMM)Wtsi/H

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Marveld2tm1b(EUCOMM)Wtsi/Marveld2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Marveld2tm1b(EUCOMM)Wtsi/H

 MP:0013294 prenatal lethality prior to heart atrial septation "death prior to the completion of heart atrial septation (Mus: E14.5-15.5)" [MGI:smb]
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Allelic Composition: Marveld2tm1b(EUCOMM)Wtsi/Marveld2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Marveld2tm1b(EUCOMM)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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