ENSG00000159399


Homo sapiens

Features
Gene ID: ENSG00000159399
  
Biological name :HK2
  
Synonyms : hexokinase 2 / HK2 / P52789
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p12
Gene start: 74833981
Gene end: 74893359
  
Corresponding Affymetrix probe sets: 202934_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000387140
Ensembl peptide - ENSP00000290573
NCBI entrez gene - 3099     See in Manteia.
OMIM - 601125
RefSeq - XM_017003945
RefSeq - NM_000189
RefSeq - XM_005264280
RefSeq - XM_011532807
RefSeq Peptide - NP_000180
swissprot - E9PB90
swissprot - P52789
Ensembl - ENSG00000159399
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hk2ENSDARG00000101482Danio rerio
 Hk2ENSMUSG00000000628Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HK1 / P19367 / hexokinase 1ENSG0000015651572
HKDC1 / Q2TB90 / hexokinase domain containing 1ENSG0000015651068
HK3 / P52790 / hexokinase 3ENSG0000016088355
GCK / P35557 / glucokinaseENSG0000010663326


Protein motifs (from Interpro)
Interpro ID Name
 IPR001312  Hexokinase
 IPR019807  Hexokinase, binding site
 IPR022672  Hexokinase, N-terminal
 IPR022673  Hexokinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001678 cellular glucose homeostasis IEA
 biological_processGO:0002931 response to ischemia IEA
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0006096 glycolytic process IEA
 biological_processGO:0007595 lactation IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008637 apoptotic mitochondrial changes IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019318 hexose metabolic process IEA
 biological_processGO:0035795 negative regulation of mitochondrial membrane permeability IEA
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0046324 regulation of glucose import IEA
 biological_processGO:0046835 carbohydrate phosphorylation IEA
 biological_processGO:0051156 glucose 6-phosphate metabolic process IEA
 biological_processGO:0061621 canonical glycolysis TAS
 biological_processGO:0072655 establishment of protein localization to mitochondrion IMP
 biological_processGO:0072656 maintenance of protein location in mitochondrion IMP
 biological_processGO:1904925 positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization IMP
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IEA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IDA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004340 glucokinase activity TAS
 molecular_functionGO:0004396 hexokinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005536 glucose binding IEA
 molecular_functionGO:0008865 fructokinase activity IBA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016773 phosphotransferase activity, alcohol group as acceptor IEA
 molecular_functionGO:0019158 mannokinase activity IBA


Pathways (from Reactome)
Pathway description
Glycolysis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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