ENSG00000160752


Homo sapiens

Features
Gene ID: ENSG00000160752
  
Biological name :FDPS
  
Synonyms : farnesyl diphosphate synthase / FDPS / P14324
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q22
Gene start: 155308748
Gene end: 155320666
  
Corresponding Affymetrix probe sets: 201275_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000478032
Ensembl peptide - ENSP00000478235
Ensembl peptide - ENSP00000484099
Ensembl peptide - ENSP00000483188
Ensembl peptide - ENSP00000480142
Ensembl peptide - ENSP00000479557
Ensembl peptide - ENSP00000349078
Ensembl peptide - ENSP00000357340
Ensembl peptide - ENSP00000391755
NCBI entrez gene - 2224     See in Manteia.
OMIM - 134629
RefSeq - XM_005244963
RefSeq - NM_001135821
RefSeq - NM_001135822
RefSeq - NM_001242824
RefSeq - NM_001242825
RefSeq - NM_002004
RefSeq - XM_005244962
RefSeq Peptide - NP_001129294
RefSeq Peptide - NP_001129293
RefSeq Peptide - NP_001229753
RefSeq Peptide - NP_001229754
RefSeq Peptide - NP_001995
swissprot - A0A087WVN4
swissprot - A0A087X1D8
swissprot - A0A087X090
swissprot - P14324
swissprot - A0A087WTP2
Ensembl - ENSG00000160752
  
Related genetic diseases (OMIM): 616631 - Porokeratosis 9, multiple types, 616631
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fdpsENSDARG00000040890Danio rerio
 FDPSENSGALG00000028880Gallus gallus
 FdpsENSMUSG00000059743Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000092  Polyprenyl synthetase
 IPR008949  Isoprenoid synthase domain superfamily
 IPR033749  Polyprenyl synthetase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0006695 cholesterol biosynthetic process TAS
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0008299 isoprenoid biosynthetic process IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016126 sterol biosynthetic process IEA
 biological_processGO:0033384 geranyl diphosphate biosynthetic process IEA
 biological_processGO:0045337 farnesyl diphosphate biosynthetic process IBA
 biological_processGO:0045540 regulation of cholesterol biosynthetic process TAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0004161 dimethylallyltranstransferase activity IBA
 molecular_functionGO:0004337 geranyltranstransferase activity IBA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Cholesterol biosynthesis
Activation of gene expression by SREBF (SREBP)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000989 Pruritus "Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased disposition to experience pruritus." [HPO:curators]
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 HP:0000992 Photosensitivity "An increased sensitivity of the skin to light. Photosensitivity may result in a rash upon exposure to the sun (which is known as photodermatosis). Photosensitivity can be diagnosed by phototests in which light is shone on small areas of skin." [HPO:curators]
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 HP:0002860 Squamous cell carcinoma 
Show

 HP:0200044 Porokeratosis "A clonal disorder of keratinization with one or multiple atrophic patches surrounded by a clinically and histologically distinctive hyperkeratotic ridgelike border called the cornoid lamella." [HPO:SKOEHLER]
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000160752 FDPS / P14324 / farnesyl diphosphate synthase  / complex






 

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