ENSG00000161031


Homo sapiens

Features
Gene ID: ENSG00000161031
  
Biological name :PGLYRP2
  
Synonyms : peptidoglycan recognition protein 2 / PGLYRP2 / Q96PD5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.12
Gene start: 15468645
Gene end: 15498956
  
Corresponding Affymetrix probe sets: 242817_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000292609
Ensembl peptide - ENSP00000345968
Ensembl peptide - ENSP00000470112
Ensembl peptide - ENSP00000472856
NCBI entrez gene - 114770     See in Manteia.
OMIM - 608199
RefSeq - XM_006722633
RefSeq - NM_052890
RefSeq Peptide - NP_443122
swissprot - M0QYW3
swissprot - Q96PD5
swissprot - M0R2W8
Ensembl - ENSG00000161031
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pglyrp2ENSDARG00000062998Danio rerio
 pglyrp6ENSDARG00000103642Danio rerio
 Q8VCS0ENSMUSG00000079563Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q96LB9 / PGLYRP3 / peptidoglycan recognition protein 3ENSG0000015952715
Q96LB8 / PGLYRP4 / peptidoglycan recognition protein 4ENSG0000016321814
O75594 / PGLYRP1 / peptidoglycan recognition protein 1ENSG0000000843813


Protein motifs (from Interpro)
Interpro ID Name
 IPR002502  N-acetylmuramoyl-L-alanine amidase domain
 IPR006619  Peptidoglycan recognition protein family domain, metazoa/bacteria
 IPR015510  Peptidoglycan recognition protein
 IPR036505  N-acetylmuramoyl-L-alanine amidase/PGRP domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001519 peptide amidation NAS
 biological_processGO:0002221 pattern recognition receptor signaling pathway IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0009253 peptidoglycan catabolic process IEA
 biological_processGO:0016045 detection of bacterium IDA
 biological_processGO:0019730 antimicrobial humoral response TAS
 biological_processGO:0032689 negative regulation of interferon-gamma production IEA
 biological_processGO:0032827 negative regulation of natural killer cell differentiation involved in immune response IEA
 biological_processGO:0044117 growth of symbiont in host IEA
 biological_processGO:0045087 innate immune response NAS
 biological_processGO:0050727 regulation of inflammatory response IEA
 biological_processGO:0050830 defense response to Gram-positive bacterium IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005622 intracellular NAS
 cellular_componentGO:0016020 membrane NAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0008745 N-acetylmuramoyl-L-alanine amidase activity EXP
 molecular_functionGO:0016019 peptidoglycan receptor activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042834 peptidoglycan binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Antimicrobial peptides


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000161031 Q96PD5 / PGLYRP2 / peptidoglycan recognition protein 2  / complex






 

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