ENSG00000159527


Homo sapiens

Features
Gene ID: ENSG00000159527
  
Biological name :PGLYRP3
  
Synonyms : peptidoglycan recognition protein 3 / PGLYRP3 / Q96LB9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q21.3
Gene start: 153297862
Gene end: 153310718
  
Corresponding Affymetrix probe sets: 1553059_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000290722
NCBI entrez gene - 114771     See in Manteia.
OMIM - 608197
RefSeq - XM_011509120
RefSeq - NM_052891
RefSeq - XM_011509118
RefSeq - XM_011509119
RefSeq Peptide - NP_443123
swissprot - Q96LB9
Ensembl - ENSG00000159527
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pglyrp5ENSDARG00000068382Danio rerio
 A1A547ENSMUSG00000042244Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q96LB8 / PGLYRP4 / peptidoglycan recognition protein 4ENSG0000016321867
Q96PD5 / PGLYRP2 / peptidoglycan recognition protein 2ENSG0000016103125
O75594 / PGLYRP1 / peptidoglycan recognition protein 1ENSG0000000843823


Protein motifs (from Interpro)
Interpro ID Name
 IPR002502  N-acetylmuramoyl-L-alanine amidase domain
 IPR006619  Peptidoglycan recognition protein family domain, metazoa/bacteria
 IPR015510  Peptidoglycan recognition protein
 IPR036505  N-acetylmuramoyl-L-alanine amidase/PGRP domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002221 pattern recognition receptor signaling pathway IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0009253 peptidoglycan catabolic process IEA
 biological_processGO:0016045 detection of bacterium IDA
 biological_processGO:0019730 antimicrobial humoral response TAS
 biological_processGO:0031640 killing of cells of other organism IDA
 biological_processGO:0032689 negative regulation of interferon-gamma production IEA
 biological_processGO:0032827 negative regulation of natural killer cell differentiation involved in immune response IEA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0044117 growth of symbiont in host IEA
 biological_processGO:0045087 innate immune response NAS
 biological_processGO:0050830 defense response to Gram-positive bacterium IDA
 biological_processGO:0051714 positive regulation of cytolysis in other organism IDA
 biological_processGO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005622 intracellular NAS
 cellular_componentGO:0016020 membrane NAS
 cellular_componentGO:0032991 protein-containing complex IDA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0008745 N-acetylmuramoyl-L-alanine amidase activity IEA
 molecular_functionGO:0016019 peptidoglycan receptor activity IDA
 molecular_functionGO:0042834 peptidoglycan binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
Antimicrobial peptides


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000159527 Q96LB9 / PGLYRP3 / peptidoglycan recognition protein 3  / complex
 ENSG00000163218 Q96LB8 / PGLYRP4 / peptidoglycan recognition protein 4  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr