ENSG00000008438


Homo sapiens

Features
Gene ID: ENSG00000008438
  
Biological name :PGLYRP1
  
Synonyms : O75594 / peptidoglycan recognition protein 1 / PGLYRP1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.32
Gene start: 46019153
Gene end: 46023065
  
Corresponding Affymetrix probe sets: 207384_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000008938
NCBI entrez gene - 8993     See in Manteia.
OMIM - 604963
RefSeq - NM_005091
RefSeq Peptide - NP_005082
swissprot - O75594
Ensembl - ENSG00000008438
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pglyrp5ENSDARG00000068382Danio rerio
 O88593ENSMUSG00000030413Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q96LB9 / PGLYRP3 / peptidoglycan recognition protein 3ENSG0000015952740
Q96LB8 / PGLYRP4 / peptidoglycan recognition protein 4ENSG0000016321838
Q96PD5 / PGLYRP2 / peptidoglycan recognition protein 2ENSG0000016103137


Protein motifs (from Interpro)
Interpro ID Name
 IPR002502  N-acetylmuramoyl-L-alanine amidase domain
 IPR006619  Peptidoglycan recognition protein family domain, metazoa/bacteria
 IPR015510  Peptidoglycan recognition protein
 IPR017331  Peptidoglycan recognition protein, PGRP-S
 IPR036505  N-acetylmuramoyl-L-alanine amidase/PGRP domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002221 pattern recognition receptor signaling pathway IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0009253 peptidoglycan catabolic process IEA
 biological_processGO:0016045 detection of bacterium IDA
 biological_processGO:0019730 antimicrobial humoral response TAS
 biological_processGO:0031640 killing of cells of other organism IDA
 biological_processGO:0032689 negative regulation of interferon-gamma production IEA
 biological_processGO:0032827 negative regulation of natural killer cell differentiation involved in immune response IEA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0044117 growth of symbiont in host IEA
 biological_processGO:0045087 innate immune response NAS
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0050830 defense response to Gram-positive bacterium IDA
 biological_processGO:0051714 positive regulation of cytolysis in other organism IDA
 biological_processGO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0035580 specific granule lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0097013 phagocytic vesicle lumen TAS
 cellular_componentGO:1904724 tertiary granule lumen TAS
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0008745 N-acetylmuramoyl-L-alanine amidase activity IEA
 molecular_functionGO:0016019 peptidoglycan receptor activity IDA
 molecular_functionGO:0042834 peptidoglycan binding IDA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Antimicrobial peptides


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000008438 O75594 / PGLYRP1 / peptidoglycan recognition protein 1  / complex






 

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