MP:0000465 | gastrointestinal hemorrhage | "bleeding in the stomach and/or the intestines" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896] |
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
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MP:0000488 | abnormal intestinal epithelium morphology | "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
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MP:0000490 | abnormal crypts of Lieberkuhn morphology | "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
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MP:0000511 | abnormal intestinal mucosa morphology | "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
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MP:0000512 | intestinal ulcer | "lesions in the mucous lining of the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
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MP:0001263 | weight loss | "progressive reduction of body weight below normal average for age" [J:45400] |
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
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MP:0002412 | increased susceptibility to bacterial infection | "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Pglyrp1tm1.1Lky/Pglyrp1tm1.1Lky Genetic Background: B6.129S4-Pglyrp1tm1.1Lky
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MP:0002463 | abnormal neutrophil physiology | "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Pglyrp1tm1.1Lky/Pglyrp1tm1.1Lky Genetic Background: B6.129S4-Pglyrp1tm1.1Lky
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MP:0003436 | resistance to induced arthritis | "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303] |
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Allelic Composition: Pglyrp1tm1Rdz/Pglyrp1tm1Rdz,Pglyrp2tm1Rdz/Pglyrp2tm1Rdz Genetic Background: C.129S-Pglyrp1tm1Rdz Pglyrp2tm1Rdz
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MP:0003449 | abnormal intestinal goblet cells | "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282] |
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
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MP:0003724 | susceptibility to induced arthritis | "more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator] |
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Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+ Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka
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MP:0005074 | defective granulocyte bactericidal activity | "inability or reduced ability of neutrophils, eosinophils, or basophils to kill bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:5405] |
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Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0008537 | increased susceptibility to induced colitis | "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
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MP:0008705 | increased interleukin-6 secretion | "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506] |
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
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MP:0008722 | abnormal chemokine secretion | "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200] |
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
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MP:0009766 | increased sensitivity to xenobiotic induced morbidity/mortality | "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
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MP:0009788 | increased susceptibility to bacterial infection induced morbidity/mortality | "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0010377 | abnormal gut flora balance | "anomaly in the ratio of microorganisms that live in the digestive tracts of animals, many of which perform symbiotic functions to the host" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
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