ENSG00000163485


Homo sapiens

Features
Gene ID: ENSG00000163485
  
Biological name :ADORA1
  
Synonyms : adenosine A1 receptor / ADORA1 / P30542
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q32.1
Gene start: 203090654
Gene end: 203167405
  
Corresponding Affymetrix probe sets: 205481_at (Human Genome U133 Plus 2.0 Array)   216220_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000308549
Ensembl peptide - ENSP00000356205
Ensembl peptide - ENSP00000491900
Ensembl peptide - ENSP00000483953
Ensembl peptide - ENSP00000338435
Ensembl peptide - ENSP00000356204
NCBI entrez gene - 134     See in Manteia.
OMIM - 102775
RefSeq - XM_005244902
RefSeq - XM_005244901
RefSeq - NM_001048230
RefSeq - NM_000674
RefSeq - XM_017000342
RefSeq Peptide - NP_001041695
RefSeq Peptide - NP_000665
swissprot - P30542
swissprot - A0A087X173
Ensembl - ENSG00000163485
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adora1aENSDARG00000070056Danio rerio
 adora1bENSDARG00000075694Danio rerio
 ADORA1ENSGALG00000000168Gallus gallus
 Adora1ENSMUSG00000042429Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P29274 / ADORA2A / adenosine A2a receptorENSG0000012827149
ADORA3 / P0DMS8 / adenosine A3 receptorENSG0000028260847
P29275 / ADORA2B / adenosine A2b receptorENSG0000017042545
P0DMS9 / TMIGD3 / transmembrane and immunoglobulin domain containing 3ENSG0000012193325
GPR119 / Q8TDV5 / G protein-coupled receptor 119ENSG0000014726223


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001068  Adenosine A1 receptor
 IPR001634  Adenosine receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0001659 temperature homeostasis IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001973 adenosine receptor signaling pathway IEA
 biological_processGO:0002087 regulation of respiratory gaseous exchange by neurological system process IEA
 biological_processGO:0002674 negative regulation of acute inflammatory response IEA
 biological_processGO:0002686 negative regulation of leukocyte migration IEA
 biological_processGO:0002793 positive regulation of peptide secretion IEA
 biological_processGO:0003093 regulation of glomerular filtration IEA
 biological_processGO:0006612 protein targeting to membrane IEA
 biological_processGO:0006909 phagocytosis TAS
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007399 nervous system development TAS
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0014050 negative regulation of glutamate secretion IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0032229 negative regulation of synaptic transmission, GABAergic IEA
 biological_processGO:0032244 positive regulation of nucleoside transport IEA
 biological_processGO:0032900 negative regulation of neurotrophin production IEA
 biological_processGO:0035307 positive regulation of protein dephosphorylation IEA
 biological_processGO:0035814 negative regulation of renal sodium excretion IEA
 biological_processGO:0042321 negative regulation of circadian sleep/wake cycle, sleep IEA
 biological_processGO:0042323 negative regulation of circadian sleep/wake cycle, non-REM sleep IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043268 positive regulation of potassium ion transport IEA
 biological_processGO:0045741 positive regulation of epidermal growth factor-activated receptor activity IEA
 biological_processGO:0045776 negative regulation of blood pressure IEA
 biological_processGO:0045777 positive regulation of blood pressure IEA
 biological_processGO:0045822 negative regulation of heart contraction IEA
 biological_processGO:0046888 negative regulation of hormone secretion IEA
 biological_processGO:0048167 regulation of synaptic plasticity IEA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0050890 cognition IEA
 biological_processGO:0050965 detection of temperature stimulus involved in sensory perception of pain IEA
 biological_processGO:0050995 negative regulation of lipid catabolic process IEA
 biological_processGO:0051930 regulation of sensory perception of pain IEA
 biological_processGO:0051967 negative regulation of synaptic transmission, glutamatergic IEA
 biological_processGO:0055117 regulation of cardiac muscle contraction IEA
 biological_processGO:0055118 negative regulation of cardiac muscle contraction IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0060087 relaxation of vascular smooth muscle IEA
 biological_processGO:0070256 negative regulation of mucus secretion IEA
 biological_processGO:0097190 apoptotic signaling pathway TAS
 biological_processGO:0097756 negative regulation of blood vessel diameter IEA
 biological_processGO:1900453 negative regulation of long term synaptic depression IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030673 axolemma IEA
 cellular_componentGO:0032279 asymmetric synapse IEA
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0048786 presynaptic active zone IEA
 cellular_componentGO:0099055 integral component of postsynaptic membrane IEA
 cellular_componentGO:0099056 integral component of presynaptic membrane IEA
 molecular_functionGO:0001609 G-protein coupled adenosine receptor activity IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IEA
 molecular_functionGO:0001883 purine nucleoside binding IEA
 molecular_functionGO:0004629 phospholipase C activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0031683 G-protein beta/gamma-subunit complex binding IEA
 molecular_functionGO:0032795 heterotrimeric G-protein binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Adenosine P1 receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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