ENSG00000170425


Homo sapiens

Features
Gene ID: ENSG00000170425
  
Biological name :ADORA2B
  
Synonyms : adenosine A2b receptor / ADORA2B / P29275
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: p12
Gene start: 15944917
Gene end: 15975746
  
Corresponding Affymetrix probe sets: 205891_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000304501
NCBI entrez gene - 136     See in Manteia.
OMIM - 600446
RefSeq - NM_000676
RefSeq Peptide - NP_000667
swissprot - P29275
Ensembl - ENSG00000170425
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adora2bENSDARG00000002533Danio rerio
 O13076ENSGALG00000014182Gallus gallus
 Q60614ENSMUSG00000018500Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P29274 / ADORA2A / adenosine A2a receptorENSG0000012827158
ADORA1 / P30542 / adenosine A1 receptorENSG0000016348545
ADORA3 / P0DMS8 / adenosine A3 receptorENSG0000028260836
P0DMS9 / TMIGD3 / transmembrane and immunoglobulin domain containing 3ENSG0000012193323
GPR119 / Q8TDV5 / G protein-coupled receptor 119ENSG0000014726221


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001435  Adenosine A2B receptor
 IPR001634  Adenosine receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity TAS
 biological_processGO:0001973 adenosine receptor signaling pathway IEA
 biological_processGO:0002882 positive regulation of chronic inflammatory response to non-antigenic stimulus IEA
 biological_processGO:0006968 cellular defense response TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007190 activation of adenylate cyclase activity TAS
 biological_processGO:0007254 JNK cascade TAS
 biological_processGO:0007588 excretion TAS
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IEA
 biological_processGO:0030828 obsolete positive regulation of cGMP biosynthetic process IEA
 biological_processGO:0031284 positive regulation of guanylate cyclase activity IEA
 biological_processGO:0031668 cellular response to extracellular stimulus IEA
 biological_processGO:0032722 positive regulation of chemokine production IEA
 biological_processGO:0032755 positive regulation of interleukin-6 production IEA
 biological_processGO:0043306 positive regulation of mast cell degranulation IEA
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0060087 relaxation of vascular smooth muscle IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001609 G-protein coupled adenosine receptor activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA


Pathways (from Reactome)
Pathway description
Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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