ENSMUSG00000018500


Mus musculus

Features
Gene ID: ENSMUSG00000018500
  
Biological name :Adora2b
  
Synonyms : adenosine A2b receptor / Adora2b / Q60614
  
Possible biological names infered from orthology : P29275
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B2
Gene start: 62248984
Gene end: 62266453
  
Corresponding Affymetrix probe sets: 10376832 (MoGene1.0st)   1434430_s_at (Mouse Genome 430 2.0 Array)   1434431_x_at (Mouse Genome 430 2.0 Array)   1434772_at (Mouse Genome 430 2.0 Array)   1450214_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000018644
NCBI entrez gene - 11541     See in Manteia.
MGI - MGI:99403
RefSeq - NM_007413
RefSeq Peptide - NP_031439
swissprot - Q60614
Ensembl - ENSMUSG00000018500
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adora2bENSDARG00000002533Danio rerio
 O13076ENSGALG00000014182Gallus gallus
 P29275ENSG00000170425Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q60613 / Adora2a / adenosine A2a receptor / P29274*ENSMUSG0000002017859
Adora1 / Q60612 / adenosine A1 receptor / P30542*ENSMUSG0000004242945
Adora3 / adenosine A3 receptor / P0DMS8*ENSMUSG0000000056236
Gpr119 / Q7TQP3 / G-protein coupled receptor 119 / Q8TDV5*ENSMUSG0000005120921
G3X8R9 / Tmigd3 / Transmembrane domain-containing protein TMIGD3 / P0DMS9* / transmembrane and immunoglobulin domain containing 3*ENSMUSG000000743446


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001435  Adenosine A2B receptor
 IPR001634  Adenosine receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001973 adenosine receptor signaling pathway IEA
 biological_processGO:0002882 positive regulation of chronic inflammatory response to non-antigenic stimulus IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IMP
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IMP
 biological_processGO:0030828 obsolete positive regulation of cGMP biosynthetic process IMP
 biological_processGO:0031284 positive regulation of guanylate cyclase activity IMP
 biological_processGO:0031668 cellular response to extracellular stimulus IDA
 biological_processGO:0032722 positive regulation of chemokine production IMP
 biological_processGO:0032755 positive regulation of interleukin-6 production IMP
 biological_processGO:0043306 positive regulation of mast cell degranulation IMP
 biological_processGO:0060087 relaxation of vascular smooth muscle IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001609 G-protein coupled adenosine receptor activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IMP


Pathways (from Reactome)
Pathway description
Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Zeb1tm1Yhi/Zeb1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000947 convulsive seizures "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adartm1b(EUCOMM)Wtsi/Adartm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Adartm1b(EUCOMM)Wtsi/J

 MP:0001379 abnormal penile erection function "altered ability to achieve a rigid and elevated state of the penis when the erectile tissue becomes filled with blood " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Zeb1tm1Yhi/Zeb1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: Adartm1b(EUCOMM)Wtsi/Adartm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Adartm1b(EUCOMM)Wtsi/J

 MP:0001711 abnormal placenta 
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Allelic Composition: Atp2a2tm1Ges/Atp2a2+,Tg(Myh6/tetO-Tnnc1*L48Q)2Jmol/0,Tg(Myh6-tTA)55Rbns/0
Genetic Background: involves: 129X1/SvJ * FVB

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Cd79atm2Cgn/Cd79atm2Cgn
Genetic Background: involves: C57BL/6 * C.B-20

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Zeb1tm1Yhi/Zeb1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adora2btm1Msit/Adora2btm1Msit,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Adora2btm1Msit/Adora2btm1Msit,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Adartm1b(EUCOMM)Wtsi/Adartm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Adartm1b(EUCOMM)Wtsi/J

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Zeb1tm1Yhi/Zeb1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Cd79atm2Cgn/Cd79atm2Cgn
Genetic Background: involves: C57BL/6 * C.B-20

 MP:0003628 abnormal lymphocyte adhesion "anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
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Allelic Composition: Cd79atm2Cgn/Cd79atm2Cgn
Genetic Background: involves: C57BL/6 * C.B-20

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adora2btm1.1Msit/Adora2btm1.1Msit
Genetic Background: either: (involves: C57BL/6) or (involves: C57BL/6 * CD-1 * ICR)

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Zeb1tm1Yhi/Zeb1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc29a1tm2Msg/Slc29a1tm2Msg,Eportm1(EGFP/cre)Uk/Epor+
Genetic Background: involves: 129X1/SvJ * BALB/cJ

Allelic Composition: Adora2btm1Msit/Adora2btm1Msit,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Zeb1tm1Yhi/Zeb1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Adora2btm1Msit/Adora2btm1Msit,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Adora2btm1.1Msit/Adora2btm1.1Msit
Genetic Background: either: (involves: C57BL/6) or (involves: C57BL/6 * CD-1 * ICR)

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6tm1Lan/Pax6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Adora2btm1.1Msit/Adora2btm1.1Msit
Genetic Background: either: (involves: C57BL/6) or (involves: C57BL/6 * CD-1 * ICR)

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Adora2btm1.1Msit/Adora2btm1.1Msit
Genetic Background: either: (involves: C57BL/6) or (involves: C57BL/6 * CD-1 * ICR)

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Cd79atm2Cgn/Cd79atm2Cgn
Genetic Background: involves: C57BL/6 * C.B-20

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Cd79atm2Cgn/Cd79atm2Cgn
Genetic Background: involves: C57BL/6 * C.B-20

Allelic Composition: Adora2btm1Dgen/Adora2btm1Dgen
Genetic Background: B6.129P2-Adora2btm1Dgen

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Pax6tm1Lan/Pax6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Adora2btm1.1Msit/Adora2btm1.1Msit
Genetic Background: either: (involves: C57BL/6) or (involves: C57BL/6 * CD-1 * ICR)

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd79atm2Cgn/Cd79atm2Cgn
Genetic Background: involves: C57BL/6 * C.B-20

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Cd79atm2Cgn/Cd79atm2Cgn
Genetic Background: involves: C57BL/6 * C.B-20

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Cd79atm2Cgn/Cd79atm2Cgn
Genetic Background: involves: C57BL/6 * C.B-20

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6tm1Lan/Pax6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6tm1Lan/Pax6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Adora2btm1.1Msit/Adora2btm1.1Msit
Genetic Background: either: (involves: C57BL/6) or (involves: C57BL/6 * CD-1 * ICR)

 MP:0009858 abnormal cellular extravasation "any anomaly in the migration of leukocytes from the blood vessels into the surrounding tissue" [GO:0045123]
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Allelic Composition: Pax6tm1Lan/Pax6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Pax6tm1Lan/Pax6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Adartm1b(EUCOMM)Wtsi/Adartm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Adartm1b(EUCOMM)Wtsi/J

 MP:0020333 enhanced leukocyte tethering or rolling "enhancement of the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation" [GO:0050901, ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Cd79atm2Cgn/Cd79atm2Cgn
Genetic Background: involves: C57BL/6 * C.B-20

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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