ENSMUSG00000020178


Mus musculus

Features
Gene ID: ENSMUSG00000020178
  
Biological name :Adora2a
  
Synonyms : adenosine A2a receptor / Adora2a / Q60613
  
Possible biological names infered from orthology : P29274
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 75316877
Gene end: 75334784
  
Corresponding Affymetrix probe sets: 10364030 (MoGene1.0st)   1427519_at (Mouse Genome 430 2.0 Array)   1460710_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152012
Ensembl peptide - ENSMUSP00000101060
Ensembl peptide - ENSMUSP00000151245
Ensembl peptide - ENSMUSP00000151503
NCBI entrez gene - 11540     See in Manteia.
MGI - MGI:99402
RefSeq - XM_006513094
RefSeq - NM_009630
RefSeq - XM_006513092
RefSeq - XM_006513093
RefSeq Peptide - NP_001318025
RefSeq Peptide - NP_033760
RefSeq Peptide - NP_001318024
swissprot - Q60613
swissprot - A0A1W2P8B2
swissprot - A0A1W2P713
Ensembl - ENSMUSG00000020178
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adora2aaENSDARG00000033706Danio rerio
 ADORA2AENSGALG00000006642Gallus gallus
 P29274ENSG00000128271Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q60614 / Adora2b / adenosine A2b receptor / P29275*ENSMUSG0000001850048
Adora1 / Q60612 / adenosine A1 receptor / P30542*ENSMUSG0000004242938
Adora3 / adenosine A3 receptor / P0DMS8*ENSMUSG0000000056231
Gpr119 / Q7TQP3 / G-protein coupled receptor 119 / Q8TDV5*ENSMUSG0000005120921
G3X8R9 / Tmigd3 / Transmembrane domain-containing protein TMIGD3 / P0DMS9* / transmembrane and immunoglobulin domain containing 3*ENSMUSG000000743445


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001513  Adenosine A2A receptor
 IPR001634  Adenosine receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001963 synaptic transmission, dopaminergic IGI
 biological_processGO:0001973 adenosine receptor signaling pathway IMP
 biological_processGO:0001975 response to amphetamine IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007271 synaptic transmission, cholinergic IEA
 biological_processGO:0007626 locomotory behavior IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0014049 positive regulation of glutamate secretion IEA
 biological_processGO:0014057 positive regulation of acetylcholine secretion, neurotransmission IEA
 biological_processGO:0014061 regulation of norepinephrine secretion IEA
 biological_processGO:0031000 response to caffeine IEA
 biological_processGO:0032230 positive regulation of synaptic transmission, GABAergic IGI
 biological_processGO:0035249 synaptic transmission, glutamatergic IEA
 biological_processGO:0035810 positive regulation of urine volume IEA
 biological_processGO:0035815 positive regulation of renal sodium excretion IEA
 biological_processGO:0040013 negative regulation of locomotion IEA
 biological_processGO:0042311 vasodilation IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042755 eating behavior IEA
 biological_processGO:0043116 negative regulation of vascular permeability IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043279 response to alkaloid IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045938 positive regulation of circadian sleep/wake cycle, sleep IEA
 biological_processGO:0046636 negative regulation of alpha-beta T cell activation IDA
 biological_processGO:0048143 astrocyte activation IEA
 biological_processGO:0048167 regulation of synaptic plasticity IEA
 biological_processGO:0048812 neuron projection morphogenesis IEA
 biological_processGO:0050714 positive regulation of protein secretion IEA
 biological_processGO:0050728 negative regulation of inflammatory response IGI
 biological_processGO:0051881 regulation of mitochondrial membrane potential IEA
 biological_processGO:0051899 membrane depolarization IEA
 biological_processGO:0051924 regulation of calcium ion transport IEA
 biological_processGO:0051968 positive regulation of synaptic transmission, glutamatergic IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0060080 inhibitory postsynaptic potential IGI
 biological_processGO:0060134 prepulse inhibition IEA
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IMP
 cellular_componentGO:0005882 intermediate filament IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030673 axolemma IEA
 cellular_componentGO:0032279 asymmetric synapse IEA
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0048786 presynaptic active zone IEA
 cellular_componentGO:0099055 integral component of postsynaptic membrane IEA
 cellular_componentGO:0099056 integral component of presynaptic membrane IEA
 molecular_functionGO:0001609 G-protein coupled adenosine receptor activity ISO
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0031802 type 5 metabotropic glutamate receptor binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0051393 alpha-actinin binding IEA


Pathways (from Reactome)
Pathway description
Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000276 right ventricle hypertrophy "increased size of the right ventricle" [J:33629]
Show

Allelic Composition: Chtf18tm1.1KhK/Chtf18tm1.2Khk,Alpltm1(cre)Nagy/Alpl+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000484 abnormal pulmonary artery morphology "structrual anomaly of the artery that arises from the right ventricle and conveys unaerated blood to the lungs " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, hdene:Howard Dene, Mouse Genome Informatics Curator]
Show

Allelic Composition: Chtf18tm1.1KhK/Chtf18tm1.2Khk,Alpltm1(cre)Nagy/Alpl+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0001354 increased aggression towards males "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward male mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
Show

Allelic Composition: Pax610Neu/Pax610Neu
Genetic Background: involves: 102 * C3H

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: Pax610Neu/Pax610Neu
Genetic Background: involves: 102 * C3H

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Prkdcscid/Prkdcscid,Tg(INS-Il10)#Sar/0
Genetic Background: NOD.Cg-Prkdcscid Tg(INS-Il10)#Sar

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
Show

Allelic Composition: Pax610Neu/Pax610Neu
Genetic Background: involves: 102 * C3H

 MP:0001423 abnormal liquid preference "the desire to drink more or less fluids than average, or to drink unusual fluids" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax610Neu/Pax610Neu
Genetic Background: involves: 102 * C3H

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pax610Neu/Pax610Neu
Genetic Background: involves: 102 * C3H

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
Show

Allelic Composition: Pax610Neu/Pax610Neu
Genetic Background: involves: 102 * C3H

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax610Neu/Pax610Neu
Genetic Background: involves: 102 * C3H

 MP:0002698 abnormal sclera morphology "structural anomaly of the fibrous, outer envelope of the eyeball, covering it entirely excepting the segment covered anteriorly by the cornea " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Prkdcscid/Prkdcscid,Tg(INS-Il10)#Sar/0
Genetic Background: NOD.Cg-Prkdcscid Tg(INS-Il10)#Sar

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax610Neu/Pax610Neu
Genetic Background: involves: 102 * C3H

 MP:0002975 vascular smooth muscle hypertrophy "increase in size or thickness of the smooth muscle of the vascular wall" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Chtf18tm1.1KhK/Chtf18tm1.2Khk,Alpltm1(cre)Nagy/Alpl+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0003043 hypoalgesia "decreased sensation to painful stimuli that may follow damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Pax610Neu/Pax610Neu
Genetic Background: involves: 102 * C3H

 MP:0003100 myopia "optical condition in which only rays from a finite distance from the eye focus on the retina" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:83544]
Show

Allelic Composition: Prkdcscid/Prkdcscid,Tg(INS-Il10)#Sar/0
Genetic Background: NOD.Cg-Prkdcscid Tg(INS-Il10)#Sar

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax610Neu/Pax610Neu
Genetic Background: involves: 102 * C3H

Allelic Composition: Adora2atm1Dyj/Adora2atm1Dyj,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Adora2atm1Dyj/Adora2atm1.1Dyj,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Adora2atm1Jfc/Adora2atm1Jfc
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Adora2atm1Jfc/Adora2atm1Jfc,Drd2tm1Low/Drd2tm1Low
Genetic Background: involves: 129 * C57BL/6

 MP:0003548 pulmonary hypertension "sustained high pulmonary pressure at a level that is likely to result in disease and/or other pathological states" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:54986]
Show

Allelic Composition: Chtf18tm1.1KhK/Chtf18tm1.2Khk,Alpltm1(cre)Nagy/Alpl+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Chtf18tm1.1KhK/Chtf18tm1.2Khk,Alpltm1(cre)Nagy/Alpl+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0006058 decreased cerebral infarction size "decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkdcscid/Prkdcscid,Tg(INS-Il10)#Sar/0
Genetic Background: NOD.Cg-Prkdcscid Tg(INS-Il10)#Sar

Allelic Composition: Adora2atm1Jfc/Adora2atm1Jfc
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0006059 decreased susceptibility to ischemic brain injury "decreased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkdcscid/Prkdcscid,Tg(INS-Il10)#Sar/0
Genetic Background: NOD.Cg-Prkdcscid Tg(INS-Il10)#Sar

Allelic Composition: Adora2atm1Jfc/Adora2atm1Jfc
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0006087 increased body mass index "greater than normal average of a measure of weight for height" [ncbi:NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax610Neu/Pax610Neu
Genetic Background: involves: 102 * C3H

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Men1tm1.1Ctre/Men1+,Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adora2atm1Jfc/Adora2atm1Jfc
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0009586 increased platelet aggregation "increase in the ability of one platelet to one or more other platelets via adhesion molecules" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax610Neu/Pax610Neu
Genetic Background: involves: 102 * C3H

 MP:0009750 impaired behavioral response to addictive substance "decreased sensitivity to an addictive substance capable of inducing the appearance of behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkdcscid/Prkdcscid,Tg(INS-Il10)#Sar/0
Genetic Background: NOD.Cg-Prkdcscid Tg(INS-Il10)#Sar

Allelic Composition: Adora2atm1Jfc/Adora2atm1Jfc
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: Adora2atm1Dyj/Adora2atm1.1Dyj,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0009755 impaired behavioral response to alcohol "decreased sensitivity to alcohol resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax610Neu/Pax610Neu
Genetic Background: involves: 102 * C3H

 MP:0010758 increased right ventricle systolic pressure "increase in the pressure in the right ventricle as the heart contracts and pumps blood into the arteries" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Chtf18tm1.1KhK/Chtf18tm1.2Khk,Alpltm1(cre)Nagy/Alpl+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0012348 decreased susceptibility to induction of seizure by inducing agent "higher threshold to induction of seizure activity response by an agent that normally can induce uncontrolled electrical activity in the brain, producing a physical convulsion and/or minor change in physical behavior" [http://orcid.org/0000-0001-5208-3432]
Show

Allelic Composition: Adktm2Bois/Adktm2Bois,Adora1tm1Bbf/Adora1tm1Bbf,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr