ENSG00000128271


Homo sapiens

Features
Gene ID: ENSG00000128271
  
Biological name :ADORA2A
  
Synonyms : adenosine A2a receptor / ADORA2A / P29274
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: 1
Band: q11.23
Gene start: 24417879
Gene end: 24442360
  
Corresponding Affymetrix probe sets: 205013_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000474097
Ensembl peptide - ENSP00000474895
Ensembl peptide - ENSP00000483102
Ensembl peptide - ENSP00000481552
Ensembl peptide - ENSP00000480012
Ensembl peptide - ENSP00000475000
Ensembl peptide - ENSP00000336630
Ensembl peptide - ENSP00000397071
Ensembl peptide - ENSP00000400190
Ensembl peptide - ENSP00000404497
Ensembl peptide - ENSP00000414802
Ensembl peptide - ENSP00000473799
NCBI entrez gene - 135     See in Manteia.
OMIM - 102776
RefSeq - NM_001278497
RefSeq - NM_001278498
RefSeq - NM_001278499
RefSeq - NM_001278500
RefSeq - NM_000675
RefSeq Peptide - NP_000666
RefSeq Peptide - NP_001265427
RefSeq Peptide - NP_001265428
RefSeq Peptide - NP_001265429
RefSeq Peptide - NP_001265426
swissprot - X5DNB4
swissprot - C9JFS2
swissprot - C9J3T2
swissprot - C9J0Z4
swissprot - P29274
swissprot - S4R2Z8
swissprot - S4R3A7
swissprot - S4R429
swissprot - C9JQD8
Ensembl - ENSG00000128271
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adora2aaENSDARG00000033706Danio rerio
 ADORA2AENSGALG00000006642Gallus gallus
 Q60613ENSMUSG00000020178Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P29275 / ADORA2B / adenosine A2b receptorENSG0000017042547
ADORA1 / P30542 / adenosine A1 receptorENSG0000016348539
ADORA3 / P0DMS8 / adenosine A3 receptorENSG0000028260831
GPR119 / Q8TDV5 / G protein-coupled receptor 119ENSG0000014726220
P0DMS9 / TMIGD3 / transmembrane and immunoglobulin domain containing 3ENSG0000012193320


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001513  Adenosine A2A receptor
 IPR001634  Adenosine receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001963 synaptic transmission, dopaminergic IEA
 biological_processGO:0001973 adenosine receptor signaling pathway IEA
 biological_processGO:0001975 response to amphetamine IEA
 biological_processGO:0006171 cAMP biosynthetic process TAS
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0006909 phagocytosis TAS
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0006968 cellular defense response TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007271 synaptic transmission, cholinergic IEA
 biological_processGO:0007417 central nervous system development TAS
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0007600 sensory perception TAS
 biological_processGO:0007626 locomotory behavior IEA
 biological_processGO:0008015 blood circulation TAS
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0014049 positive regulation of glutamate secretion IEA
 biological_processGO:0014057 positive regulation of acetylcholine secretion, neurotransmission IEA
 biological_processGO:0014061 regulation of norepinephrine secretion IEA
 biological_processGO:0031000 response to caffeine IEA
 biological_processGO:0032230 positive regulation of synaptic transmission, GABAergic IEA
 biological_processGO:0035249 synaptic transmission, glutamatergic IEA
 biological_processGO:0035810 positive regulation of urine volume IEA
 biological_processGO:0035815 positive regulation of renal sodium excretion IEA
 biological_processGO:0040013 negative regulation of locomotion IEA
 biological_processGO:0042311 vasodilation IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042755 eating behavior IEA
 biological_processGO:0043116 negative regulation of vascular permeability IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043279 response to alkaloid IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0045938 positive regulation of circadian sleep/wake cycle, sleep IEA
 biological_processGO:0046636 negative regulation of alpha-beta T cell activation IEA
 biological_processGO:0048143 astrocyte activation IEA
 biological_processGO:0048167 regulation of synaptic plasticity IEA
 biological_processGO:0048812 neuron projection morphogenesis IEA
 biological_processGO:0050714 positive regulation of protein secretion IEA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0051881 regulation of mitochondrial membrane potential IEA
 biological_processGO:0051899 membrane depolarization IEA
 biological_processGO:0051924 regulation of calcium ion transport IEA
 biological_processGO:0051968 positive regulation of synaptic transmission, glutamatergic IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0060080 inhibitory postsynaptic potential IEA
 biological_processGO:0060134 prepulse inhibition IEA
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IEA
 cellular_componentGO:0005882 intermediate filament IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030673 axolemma IEA
 cellular_componentGO:0032279 asymmetric synapse IEA
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0048786 presynaptic active zone IEA
 cellular_componentGO:0099055 integral component of postsynaptic membrane IEA
 cellular_componentGO:0099056 integral component of presynaptic membrane IEA
 molecular_functionGO:0001609 G-protein coupled adenosine receptor activity IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0031802 type 5 metabotropic glutamate receptor binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0051393 alpha-actinin binding IEA


Pathways (from Reactome)
Pathway description
NGF-independant TRKA activation
Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000148053 NTRK2 / Q16620 / neurotrophic receptor tyrosine kinase 2  / complex / reaction
 ENSG00000198400 NTRK1 / P04629 / neurotrophic receptor tyrosine kinase 1  / complex / reaction






 

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