ENSMUSG00000074344


Mus musculus

Features
Gene ID: ENSMUSG00000074344
  
Biological name :Tmigd3
  
Synonyms : G3X8R9 / Tmigd3 / Transmembrane domain-containing protein TMIGD3
  
Possible biological names infered from orthology : P0DMS9 / transmembrane and immunoglobulin domain containing 3
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.2
Gene start: 105870903
Gene end: 105924042
  
Corresponding Affymetrix probe sets: 10495097 (MoGene1.0st)   1429609_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142671
Ensembl peptide - ENSMUSP00000143674
Ensembl peptide - ENSMUSP00000143300
Ensembl peptide - ENSMUSP00000142695
Ensembl peptide - ENSMUSP00000010279
NCBI entrez gene - 69296     See in Manteia.
MGI - MGI:5604098
RefSeq - NM_027025
RefSeq Peptide - NP_081301
swissprot - A0A0G2JGS1
swissprot - G3X8R9
swissprot - A0A0G2JEA6
swissprot - A0A0G2JE84
Ensembl - ENSMUSG00000074344
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CR847944.1ENSDARG00000026246Danio rerio
 CR847944.2ENSDARG00000059899Danio rerio
 si:ch211-233f11.5ENSDARG00000044061Danio rerio
 ADORA3ENSGALG00000001462Gallus gallus
 P0DMS9ENSG00000121933Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q60613 / Adora2a / adenosine A2a receptor / P29274*ENSMUSG0000002017810
Q60614 / Adora2b / adenosine A2b receptor / P29275*ENSMUSG000000185009
Adora1 / Q60612 / adenosine A1 receptor / P30542*ENSMUSG000000424298
Adora3 / adenosine A3 receptor / P0DMS8*ENSMUSG000000005628
Gpr119 / Q7TQP3 / G-protein coupled receptor 119 / Q8TDV5*ENSMUSG000000512096


Protein motifs (from Interpro)
Interpro ID Name
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000229 abnormal megakaryocyte differentiation "atypical process of formation and development these very large bone marrow cells which release mature platelets" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mybpc3tm2.1Lcrr/Mybpc3+
Genetic Background: involves: 129S2/SvPasCrl * Black Swiss

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mybpc3tm2.1Lcrr/Mybpc3+
Genetic Background: involves: 129S2/SvPasCrl * Black Swiss

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mybpc3tm2.1Lcrr/Mybpc3+
Genetic Background: involves: 129S2/SvPasCrl * Black Swiss

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
Show

Allelic Composition: Mybpc3tm2.1Lcrr/Mybpc3+
Genetic Background: involves: 129S2/SvPasCrl * Black Swiss

 MP:0013704 increased megakaryocyte-erythroid progenitor cell number "increase in the number of a progenitor cell committed to the megakaryocyte and erythroid lineages" [CL:0000050]
Show

Allelic Composition: Mybpc3tm2.1Lcrr/Mybpc3+
Genetic Background: involves: 129S2/SvPasCrl * Black Swiss

 MP:0013891 increased common myeloid progenitor cell number "increased number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [MGI:llw2]
Show

Allelic Composition: Mybpc3tm2.1Lcrr/Mybpc3+
Genetic Background: involves: 129S2/SvPasCrl * Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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