ENSMUSG00000000562


Mus musculus

Features
Gene ID: ENSMUSG00000000562
  
Biological name :Adora3
  
Synonyms : adenosine A3 receptor / Adora3
  
Possible biological names infered from orthology : P0DMS8
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.2
Gene start: 105870858
Gene end: 105908926
  
Corresponding Affymetrix probe sets: 10495107 (MoGene1.0st)   1430482_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000574
Ensembl peptide - ENSMUSP00000126710
NCBI entrez gene - 11542     See in Manteia.
NCBI entrez gene - 69296     See in Manteia.
MGI - MGI:104847
RefSeq - NM_001174169
RefSeq - NM_009631
RefSeq Peptide - NP_001167640
RefSeq Peptide - NP_033761
swissprot - Q3U4C5
swissprot - Q497R5
Ensembl - ENSMUSG00000000562
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CR847944.1ENSDARG00000026246Danio rerio
 CR847944.2ENSDARG00000059899Danio rerio
 si:ch211-233f11.5ENSDARG00000044061Danio rerio
 ADORA3ENSGALG00000001462Gallus gallus
 ADORA3ENSG00000282608Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adora1 / Q60612 / adenosine A1 receptor / P30542*ENSMUSG0000004242945
Q60613 / Adora2a / adenosine A2a receptor / P29274*ENSMUSG0000002017840
Q60614 / Adora2b / adenosine A2b receptor / P29275*ENSMUSG0000001850038
Gpr119 / Q7TQP3 / G-protein coupled receptor 119 / Q8TDV5*ENSMUSG0000005120918
G3X8R9 / Tmigd3 / Transmembrane domain-containing protein TMIGD3 / P0DMS9* / transmembrane and immunoglobulin domain containing 3*ENSMUSG000000743445


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000466  Adenosine A3 receptor
 IPR001634  Adenosine receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001973 adenosine receptor signaling pathway IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001609 G-protein coupled adenosine receptor activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA


Pathways (from Reactome)
Pathway description
Adenosine P1 receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002335 decreased airway responsiveness "less easily provoked into bronchoconstriction during bronchial provocation testing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gata6tm1Gsv/Gata6tm1Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB)

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: ApcMin/ApcMin,Asphtm1Jed/Asphtm1Jed
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J * C57BL/6NTac

Allelic Composition: Adora3tm1(ADORA3)Msth/Adora3tm1(ADORA3)Msth
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002736 abnormal nociception after inflammation "changes in pain thresholds after inflammation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gata6tm1Gsv/Gata6tm1Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB)

 MP:0002843 decreased blood pressure "decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gata6tm1Gsv/Gata6tm1Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB)

 MP:0003022 increased coronary flow rate "elevated rate of blood flow in the blood vessels supplying the heart" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Gata6tm1Gsv/Gata6tm1Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB)

 MP:0003038 decreased infarction size "decreased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Gata6tm1Gsv/Gata6tm1Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB)

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gata6tm1Gsv/Gata6tm1Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB)

Allelic Composition: Adora3tm1Jbsn/Adora3tm1Jbsn
Genetic Background: B6.129P2-Adora3tm1Jbsn

 MP:0004042 decreased susceptibility to kidney reperfusion injury "a diminished likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Adora3tm1Jbsn/Adora3tm1Jbsn
Genetic Background: B6.129P2-Adora3tm1Jbsn

 MP:0005087 reduced acute inflammation "less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0, J:74478]
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Allelic Composition: Gata6tm1Gsv/Gata6tm1Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB)

 MP:0005260 ocular hypotension "abnormally low intraocular pressure" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gata6tm1Gsv/Gata6tm1Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB)

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Gata6tm1Gsv/Gata6tm1Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB)

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: ApcMin/ApcMin,Asphtm1Jed/Asphtm1Jed
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J * C57BL/6NTac

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adora3tm1Jbsn/Adora3tm1Jbsn
Genetic Background: B6.129P2-Adora3tm1Jbsn

 MP:0008763 abnormal mast cell degranulation "abnormalities in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell" [GO:0043303, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Adora3tm1Jbsn/Adora3tm1Jbsn
Genetic Background: B6.129P2-Adora3tm1Jbsn

 MP:0008765 decreased mast cell degranulation "reduction in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell" [GO:0043303, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Adora3tm1(ADORA3)Msth/Adora3tm1(ADORA3)Msth
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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